A5001370848- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Genetic Mapping and Diversity in Plants and Animals
- Ruminant Nutrition and Digestive Physiology
- Molecular Biology Techniques and Applications
- Meat and Animal Product Quality
- Natural Compound Pharmacology Studies
- Ginger and Zingiberaceae research
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Biliary and Gastrointestinal Fistulas
- Natural product bioactivities and synthesis
- Probiotics and Fermented Foods
- RNA Research and Splicing
- Aquaculture disease management and microbiota
- Nail Diseases and Treatments
- Medicinal Plant Pharmacodynamics Research
- Extracellular vesicles in disease
- Ziziphus Jujuba Studies and Applications
- Circular RNAs in diseases
- Animal Genetics and Reproduction
- Animal Nutrition and Physiology
- Nuts composition and effects
- Herbal Medicine Research Studies
Jinan University
2022-2025
Lanzhou University
2024
Institute of Grassland Research
2024
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2024
Ministry of Agriculture and Rural Affairs
2024
Gansu Agricultural University
2022-2024
Guangdong Pharmaceutical University
2021-2023
China University of Mining and Technology
2022
First People's Hospital of Yunnan Province
2020
Qujing Normal University
2019
Rumen microbes play an important role in the growth and development of ruminants. Differences variety will affect rumen community structure. The three excellent sheep breeds were selected for this study (Hu sheep, Tan Dorper sheep) have different uses origins. raised on same diet to 180 d age a consistent environment. 16S rDNA V3 V4 region sequencing was used assess individuals (60 per breed). There differences microbial diversity among (P < 0.05). Principal coordinate analysis showed that...
The abundance of domesticated sheep varieties and phenotypes is largely the result long-term natural artificial selection. However, there limited information regarding genetic mechanisms underlying phenotypic variation induced by domestication improvement sheep. In this study, to explore genomic diversity selective regions at genome level, we sequenced genomes 100 across 10 breeds combined these results with publicly available data from 225 individuals, including improved breeds, Chinese...
The study of the fungal communities skin constitutes a pivotal component microbiome research. Within these communities, genus Malassezia stands out as major constituent, representing 50% to 80% total colonization on healthy individuals. excessive growth or metabolic irregularities this are intimately connected with onset various disorders that intrinsically linked its lipid-dependent nature. Cutaneous lipid metabolism is indispensable for maintaining barrier function and health. possesses...
Fecal scores are crucial for assessing the digestive and gastrointestinal status of animals. The Bristol fecal scoring system is a commonly used method subjective evaluation host feces, there limited research on standards fattening Hu sheep. In this study, sheep were collected rumen, rectum, colon contents 16S rDNA sequencing. 514 feces scored based system, production performance at each stage was measured. Finally, we developed standard manure in period (a total five grades). result shows...
In sheep meat production, the rib eye area is an important index to evaluate carcass traits. However, conventional breeding programs have led slow genetic progression in muscle area. Operationalizing molecular marker assisted optimized method that might improve this situation. Therefore, present study used whole genome sequencing data excavate candidate genes associated with muscle. Male Hu lambs ( n = 776) pedigrees and 274 no pedigree were included. The parameters of estimated using a...
Abstract Neuregulin 1 (NRG1), a gene involved with myelin production has been shown to have positive correlation schizophrenia. Event‐related potentials (ERPs) studies provide the evidence of disturbed electrophysiologic marker in The present study investigated association NRG1 genotypes P300 Three polymorphisms were detected 287 Chinese Han schizophrenics and 120 healthy control subjects. Among total sample, 140 patients 96 controls underwent P300. There no significant differences for...
Fat deposition is an important economic trait that closely related to feed efficiency and carcass performance in livestock. In this study, the fat deposition-related traits of 1,293 Hu sheep were measured descriptive statistical analysis was conducted. The results showed coefficient variation all higher than 24%. addition, single nucleotide polymorphisms expression characteristics TRAPPC9 (encoding trafficking protein particle complex subunit 9) BAIAP2 brain-specific Angiogenesis inhibitor...
The marbling fat regulates the flavor of mutton and measures density in loin eye is most important parameter carcass grading. objective this study was to explore relationship rumen microbiota grade. One hundred eighty-seven feedlot-finished Hu male lambs (Age: 180 day; Final BW: 46.32 ± 6.03 kg) were slaughtered, ruminal contents grade collected. Ruminal microbial DNA extraction 16S rRNA gene sequencing performed investigate composition predict metabolic pathways. animal cohort then grouped...
In animal husbandry, feed efficiency is a crucial economic trait. this study, the general linear model was used to perform association analysis for various genotypes and conversion ratio (FCR)-related traits. Reverse transcription-quantitative PCR (RT-qPCR) detect expression of SHISA3 RFC3 mRNA levels in 10 tissues from 6 sheep. The results showed that SNPs NC_040257.1:c.625 T &gt; C NC_040261.1:g.9905 were analyzed whether they associated parameters Hu sheep (body weight, intake,...
In the mutton industry, feed efficiency traits have greatest influence on economic benefits of sheep raised in housing conditions. this study, quantitative real-time PCR (qRT-PCR), Sanger sequencing, and KASPar methods were used to detect expression levels B cell scaffold protein with ankyrin repeats 1 (BANK1) gene relationship between its polymorphism Hu sheep. The qRT-PCR results showed that BANK1 was extensively expressed 10 tissues it at remarkably higher lymph than other (p < 0.05)....
Sheep are one of the globally significant livestock, providing meat, dairy products, and wool for human life, playing an indispensable role in civilization. Despite advancements microbiome research recent years, most studies have focused solely on rumen, lacking a comprehensive study covering different gastrointestinal tract (GIT) regions sheep. In this study, we collected 338 samples from 10 sheep GIT systematically investigated their signatures, including community structure, enterotypes,...
Icariside II is a flavonoid extracted from Epimedium that has antioxidant, anti‑inflammatory and antiapoptotic effects. The aim of the present study was to evaluate effects icariside on diabetic cardiomyopathy in streptozotocin-induced rats. treatment improved body weight, heart/body weight ratio fasting blood glucose model demonstrated reduce expression levels creatine kinase lactate dehydrogenase serum, lower cardiac oxidative stress, inflammation apoptosis induced phosphoinositide...
Circular RNA (circRNA), as a new members of noncoding family, have vital functions in many biological processes by microRNA sponges or competing endogenous RNAs (ceRNAs). However, little has been reported about the genetic mechanism circRNAs regulation feed efficiency sheep.This study aimed to explore expression liver Hu sheep with High-RFI (High residual intake) and Low-RFI (Low using transcriptome sequencing. A total 20,729 were identified two groups, which 219 found significantly...
Excessive fat deposition in the tail of sheep will affect its feed efficiency, which increase feeding cost. The purpose this study was to identify single nucleotide polymorphisms (SNPs) RAP1GAP and rBAT genes by PCR amplification Sanger sequencing, SNPs were genotyped KASP genotyping assays evaluate their association with traits. results showed that two intronic mutations g.13561 G > A g.1460 T C found rBAT, respectively. There three genotypes GG, AG, AA CC, CT TT at these loci, Association...
Animal growth traits are important and complex that determine the productivity of animal husbandry. There many factors affect traits, among which diet digestion is key factor. In process absorption, role gastrointestinal microbes essential. this study, we transplanted two groups sheep intestinal microorganisms with different body weights into intestines mice same age to observe effect fecal bacteria transplantation on characteristics mouse model. The results showed receiving microbiota (FMT)...
Many options exist for the management of cholelithiasis and secondary choledocholithiasis. Among them, laparoscopic common bile duct exploration (LCBDE) with choledocotomy followed by cholecystectomy has gained popularity. However, efforts should be made to ensure minimally invasive or noninvasive (CBD). The purpose this study was explore clinical experience non-invasive surgical modality, i.e., transcystic dilation cystic confluence in CBD (LTD-CBDE), including feasibility, safety, adverse...
Malassezia is a genus of commensal and lipid-dependent yeasts in human skin which also have pathogenic lifestyle associated with several common disorders such as atopic dermatitis eczema. Symptoms include red, itchy, inflamed skin. We studied the growth characteristics biochemical analyses M. furfur showed that protein contents were greater extracts taken at 24 h. These then used to infect C57BL/6 mice, resulting rupture. Polygalaxanthone III (POL), more effective anti-inflammatory...
Researches on drug delivery system (DDS) have made incredible progress, but there are still problems such as insufficient targeting and undesirable treatment efficiency. To improve the above problems, a stem cell-based DDS was developed. Stem cell its derivatives (cell membranes, extracellular vesicles/exosomes) been used important vehicles in of number human key diseases, genetic cancer so on. For cells highly express chemokine receptors CCR2 CXCR4, which can specifically bind to chemokines...
Polygala japonica Houtt. (PJ), a member of the L. family that is suggested to exhibit detoxification properties in traditional Chinese medicine, often used treat upper respiratory tract infections. The anti-inflammatory effects four main components PJ (POL, PS-XLIX, PS-E, and PS-F) were examined using LPS(0.3 μg·mL-1)-stimulated RAW264.7 macrophage model. levels NO, ROS, iNOS analyze activity POL. Additionally, extracellular inflammation-related cytokines chemokines measured quantibody...
In this study, a single nucleotide polymorphism of HTR4 (hydroxytryptamine receptor 4) was detected using DNA sequencing and KASPar (Kompetitive Allele-Specific PCR) technique with the aim analyzing its effect on growth traits in 1102 sheep. A synonymous mutation g.101220 C > T located fifth intron ovis gene detected, association analysis showed that significantly associated sheep (p <.05), TT genotypes having lower body weight, height, length chest circumference than TC CC genotypes. It...