A5100762702- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Microtubule and mitosis dynamics
- Circular RNAs in diseases
- Extracellular vesicles in disease
- High Altitude and Hypoxia
- Epigenetics and DNA Methylation
- Neuroscience of respiration and sleep
- COVID-19 Clinical Research Studies
- Ruminant Nutrition and Digestive Physiology
- Cancer, Hypoxia, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Mapping and Diversity in Plants and Animals
- Ubiquitin and proteasome pathways
- Obstructive Sleep Apnea Research
- Cancer-related gene regulation
- Advanced Glycation End Products research
- Disaster Response and Management
- Phytochemical compounds biological activities
- Neural Networks and Reservoir Computing
- COVID-19 Impact on Reproduction
- TGF-β signaling in diseases
- Antimicrobial Peptides and Activities
Linyi People's Hospital
2018-2025
Lanzhou University
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Shanghai East Hospital
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2023-2024
Ministry of Agriculture Livestock and Fisheries
2024
Ministère de l'Agriculture et de la Souveraineté alimentaire
2024
Institute of Grassland Research
2023-2024
Shandong University
2024
Purpose We aimed to exploit a urine exosomal long non-coding RNAs (lncRNAs) fingerprint facilitate the early diagnosis of bladder cancer. Methods Microarray differential expression profiling lncRNAs was for first time employed in exosomes from 10 non-muscle-invasive cancer (NMIBC) patients and healthy controls screen out candidate lncRNA biomarkers, which were then verified by quantitative real-time polymerase chain reaction three independent phases including cells, culture fluid 200 NMIBC...
Heritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host genetics-rumen interactions and their association with phenotype in sheep. To solve this, we curated analyzed whole-genome resequencing genotypes, 16S rumen-microbiota data, longitudinal body weight (BW) phenotypes from 1150 sheep.A variance component model indicated significant heritability microbial community diversity. Genome-wide studies (GWAS) using...
Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a few common failures errors genomic studies. Here, we report complete, gap-free telomere-to-telomere (T2T) of ram (T2T-sheep1.0) with size 2.85 Gb, including all autosomes chromosomes X Y. It adds 220.05 Mb previously unresolved regions (PURs) 754 new genes the most updated assembly, ARS-UI_Ramb_v3.0, contains four types repeat units (SatI, SatII, SatIII, CenY) centromeric...
MicroRNAs (miRs) are short, highly conserved small noncoding RNA molecules with fundamental roles in regulating gene expression. To identify miR biomarkers associated idiopathic pulmonary fibrosis (IPF), the expression pattern of miRs exosomes from bronchoalveolar lavage fluid (BALF) elderly patients IPF were evaluated. High‑throughput quantitative detection using a microarray indicated that miR‑125b, miR‑128, miR‑21, miR‑100, miR‑140‑3p and miR‑374b upregulated IPF, while let‑7d, miR‑103,...
Histone acetyltransferase GCN5 is a critical component of the TGF-β/Smad signaling pathway in breast cancer cells; however, it remains unknown whether involved development and progression cancer. The present study investigated role induction EMT by TGF-β1 cells its underlying molecular mechanism action. activity was elevated mRNA expression protein were increased MDA-MB231 following stimulation with TGF-β1. Furthermore, decreased epithelial cell marker E-cadherin mesenchymal markers,...
Breast cancer is one of the most common and lethal cancers in women. As a hub gene involved diversity tumors, ubiquitin-conjugating enzyme H10 (UbcH10), may also play some roles genesis development breast cancer. In current study, we found that expression UbcH10 was up-regulated tissues five cell lines. We established dual drug resistant line MCF-7/EPB (epirubicin)/TXT (docetaxel) lentiviral system expressing shRNA to investigate effects knockdown on chemosensitivity MCF-7/EPB/TXT cells...
The study aimed to prospectively evaluate correlations between dynamic contrast-enhanced (DCE) MR perfusion imaging, pulmonary function tests (PFT) and volume quantitative CT in smokers with or without chronic obstructive disease (COPD) determine the value of DCE-MR imaging volumetric on assessment smokers. According ATS/ERS guidelines, 51 male were categorized into five groups: At risk for COPD (n = 8), mild 9), moderate 12), severe 10), very 12). Maximum slope increase (MSI), positive...
We aimed to investigate the epidemiological and clinical features, medical care-seeking process of patients with 2019 coronavirus disease (COVID-19) in Wuhan, China, provide useful information contain COVID-19 other places similar outbreaks virus.
Abstract Background Atherosclerosis is the pathological basis of cardio-cerebrovascular diseases. Oxidized low-density lipoprotein (ox-LDL) an important risk factor for atherosclerosis. Ox-LDL leads to endothelial cell (EC) damage and dysfunction through various processes promotes occurrence deterioration High mobility group box-1 (HMGB1) a protein associated with cellular damage. In present study, effect HMGB1 on ox-LDL-induced EC was determined underlying mechanism explored. Materials...
Abstract Background Chromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel therapy for non-small cell lung cancer (NSCLC). UbcH10 considered to be associated with the pathological types clinical grades of NSCLC. KIAA0101, which contains highly conserved proliferating nuclear antigen (PCNA)-binding motif that involved DNA repair cells, plays role...
The incidence of lung cancer (LC) in chronic obstructive pulmonary disease (COPD) patients is dozens times higher than that without COPD. Elevated activity nuclear factor-k-gene binding (NF-κB) was found tissue with COPD, and the continuous activation NF-κB observed both malignant transformation tumor progression LC, suggesting its regulators may play a key role LC COPD patients. Here, we report for first time long non-coding RNA (lncRNA)-ICL involved regulation tissues analyses showed...
An important member of the defensin family, β-defensin 2, is believed to play an role in defense against foreign pathogens. In present study, we constructed lentiviral vectors express and knockdown 2 rat lungs. The results showed that infection overexpression lentivirus shRNA effectively increased suppressed expression lung, respectively. mediated by vector protected lung from Pseudomonas aeruginosa, but targeting aggregated damage lung. addition, also found basal anti-inflammatory cytokine...
In 2002, a new invasive pest ant in the genus, Nylanderia (formerly Paratrechina), was found Houston, TX. This has been causing significant economic and ecological damage infested areas. Because of morphological behavioral similarities to pubens Forel (Caribbean crazy ant) Florida, this named sp. nr. (Rasberry ant). So far, morphometric phylogenetic analyses have not determined if two ants are same or separate species. To determine relationships between populations, molecular approach...