A5100717547- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Ruminant Nutrition and Digestive Physiology
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- RNA modifications and cancer
- RNA Research and Splicing
- Meat and Animal Product Quality
- Growth Hormone and Insulin-like Growth Factors
- Animal Genetics and Reproduction
- Marine Bivalve and Aquaculture Studies
- Invertebrate Immune Response Mechanisms
- Adipose Tissue and Metabolism
- Calcium Carbonate Crystallization and Inhibition
- Probiotics and Fermented Foods
- Galectins and Cancer Biology
- Ocean Acidification Effects and Responses
- Organoboron and organosilicon chemistry
- Aquaculture disease management and microbiota
- Epigenetics and DNA Methylation
- Plant and fungal interactions
- RNA and protein synthesis mechanisms
- Nutrition, Genetics, and Disease
- Effects of Environmental Stressors on Livestock
Ministry of Agriculture and Rural Affairs
2023-2025
Lanzhou University
2022-2024
Institute of Grassland Research
2023-2024
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2023-2024
Ministry of Agriculture Livestock and Fisheries
2024
Ministère de l'Agriculture et de la Souveraineté alimentaire
2024
Gansu Agricultural University
2019-2023
Key Laboratory of Guangdong Province
2023
South China Agricultural University
2021-2023
Hebei University of Science and Technology
2023
Feed efficiency is a highly important economic trait in sheep production and has significant impact on the benefits of farming. Microbial fermentation rumen vital role host's nutrition; microbiota might affect host feed efficiency. However, relationship between unclear. In present study, 195 Hu was investigated their residual intake (RFI), commonly used measure efficiency, determined. From birth, all were subjected to same management practices. At slaughter, samples liquid contents collected...
Machine learning (ML) classifiers have been widely deployed to detect Android malware, but at the same time application of ML also faces an emerging problem. The performance such degrades---or called ages---significantly over given malware evolution. Prior works proposed use retraining or active reverse and improve aged models. However, underlying classifier itself is still blind, unaware Unsurprisingly, evolution-insensitive comes a price, i.e., labeling tens thousands samples cost...
Rumen microbes play an important role in the growth and development of ruminants. Differences variety will affect rumen community structure. The three excellent sheep breeds were selected for this study (Hu sheep, Tan Dorper sheep) have different uses origins. raised on same diet to 180 d age a consistent environment. 16S rDNA V3 V4 region sequencing was used assess individuals (60 per breed). There differences microbial diversity among (P < 0.05). Principal coordinate analysis showed that...
Heritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host genetics-rumen interactions and their association with phenotype in sheep. To solve this, we curated analyzed whole-genome resequencing genotypes, 16S rumen-microbiota data, longitudinal body weight (BW) phenotypes from 1150 sheep.A variance component model indicated significant heritability microbial community diversity. Genome-wide studies (GWAS) using...
Abstract The Hulunbuir short-tailed sheep (Ovis aries) is a breed native to China, in which the short-tail phenotype result of artificial and natural selection favoring specific set genetic mutations. Here, we analyzed differences between normal-tail phenotypes at genomic level. Selection signals were identified genome-wide sequences. From 16 sheep, 72,101,346 single nucleotide polymorphisms. detected based on fixation index heterozygosity. Seven regions under putative identified, these...
The abundance of domesticated sheep varieties and phenotypes is largely the result long-term natural artificial selection. However, there limited information regarding genetic mechanisms underlying phenotypic variation induced by domestication improvement sheep. In this study, to explore genomic diversity selective regions at genome level, we sequenced genomes 100 across 10 breeds combined these results with publicly available data from 225 individuals, including improved breeds, Chinese...
ABSTRACT Increasing strain on feed resources has led to a gradual increase in input costs, making it necessary improve efficiency livestock and poultry. In this study, Hu sheep were divided into two groups (high low conversion ratio [FCR]) according the FCR. Based 16S rDNA amplicon sequencing technology compare rumen small intestine microbial composition, differences similarities of production performance, expression level intestinal nutrient-specific carrier, digestive enzyme activity,...
In the genetic improvement of livestock and poultry, residual feed intake (RFI) is an important economic trait. However, in sheep, regulatory mechanisms RFI are unclear. present study, we measured efficiency (FE)-related phenotypes 137 male Hu lambs, selected six lambs with very high (n = 3) low values analyzed their liver transcriptomes. A total 101 differentially expressed genes (DEGs) were identified, which 40 upregulated 61 downregulated Low-RFI group compared that High-RFI group. The...
In sheep meat production, the rib eye area is an important index to evaluate carcass traits. However, conventional breeding programs have led slow genetic progression in muscle area. Operationalizing molecular marker assisted optimized method that might improve this situation. Therefore, present study used whole genome sequencing data excavate candidate genes associated with muscle. Male Hu lambs ( n = 776) pedigrees and 274 no pedigree were included. The parameters of estimated using a...
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic sheep lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome 2357 individuals across 29 breeds worldwide, 4006 phenotypic related tail fat weight. We constructed first multi-tissue epigenome atlas terms elements, chromatin states, their functions explored utility elements interpreting...
Abstract Improving feed efficiency would increase profitability for producers. The objective of this study was to detect the expression levels ME1 and CA1 polymorphisms associated with conversion ratio (FCR) residual intake (RFI) Hu sheep by using qRT‐PCR, pooled DNA sequencing KASPar assay. qRT‐PCR results indicated that were significantly higher in liver tissues low‐RFI than those high‐RFI ( p <.01). Association analysis demonstrated polymorphism g.453 C > T FCR RFI <.05). g.199...
The present study aimed to investigate the relationship between growth performance, body composition, and fat deposition factors, feed efficiency in growing lambs. We measured average daily intake (ADFI) weight (BW) from 653 Hu sheep that were fed a pellet diet. residual (RFI) not significantly genetic phenotypic correlated with metabolic (MBW) gain (ADG), but it was ADFI conversion ratio (FCR) (p < 0.01). However, FCR associated traits With same ADG, greater animals low compared high...
Scrotal circumference is an important reproductive index of breeding rams, which has a high genetic correlation with ejaculation volume and semen quality. In this study, the scrotal 1353 male Hu sheep at different stages development was measured descriptive statistical analysis performed. The results showed that coefficient variation each stage greater than 10%, its heritability were moderately to high, ranging from 0.318 0.719. We used PCR amplification Sanger sequencing scan polymorphisms
The aims of this study were to analyze the effects PPARGC1B and ZEB2 polymorphisms on body weight Hu sheep. DNA sequencing KASPar technologies used detect single nucleotide (SNPs) within genes sheep (n = 207). Two synonymous mutations, g.300 G > A g.645 C T, detected in ZEB2, respectively. weights recorded at 80, 100, 120, 140, 160 180-days, associations between these changes analyzed. Association analysis demonstrated that significantly associated with (p < 0.05). At locus, individuals GG...
Brucellosis is a zoonotic disease and major public health problem. However, the genetic mechanism of brucellosis in sheep remains unclear. In this study, serum samples were collected from 6,358 F2 population (Dorper ♂ × Hu ♀), antibody levels continuously measured at 14 days 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 months after administration vaccine. Finally, 19 brucellosis-resistant group (BRG) 22 brucellosis-susceptible (BSG) screened for whole-genome sequencing. Using fixation index, Fisher’s exact...
Fat deposition is the key factor affecting efficiency of animal husbandry production. There are many factors fat deposition, in which gastrointestinal microbiota plays an important role. Therefore, body mass index (BMI) was introduced into evaluation sheep and different functional pathways tract BMI groups were analyzed. We selected 5% individuals with highest lowest from a feed test population (357 whole group). Microorganisms 10 sites 36 (18 each group) evaluated by 16S rRNA V3−V4 region...
The biosynthesis of shell is a complicated calcification process in the marine bivalve, which can be severely impacted by ocean acidification (OA). Calmodulin (CaM) pivotal calcium regulator and thought to crucial for calcification. In present study, CaM (designated Cg CaM) with calcium-binding activity was identified from Pacific oyster Crassostrea gigas objective understand its possible role regulation homeostasis under treatment. open reading frame (ORF) 474 bp encoding 17.5 kDa protein...
Novel Duck Reovirus (NDRV) that has been found throughout the world in waterfowl, and it extensively described. Here, we report complete genome sequence of a NDRV strain isolated China called YF10. This was collected from 87 samples with infected ducks South Coastal Area. The consists 23,419 bp. With assistance computer analysis, promoter terminator each gene segment 10 viral genes segments were identified, which encode polypeptides ranging 98 to 1,294 amino acids. All fragments this virus...