A5005592324- Physiological and biochemical adaptations
- Meat and Animal Product Quality
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Single-cell and spatial transcriptomics
- Reproductive biology and impacts on aquatic species
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Aquaculture disease management and microbiota
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- Fish Ecology and Management Studies
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Skin Protection and Aging
- Animal Genetics and Reproduction
- Gene Regulatory Network Analysis
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Cell Image Analysis Techniques
- Iron Metabolism and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- NF-κB Signaling Pathways
- Stress Responses and Cortisol
Shanghai Ocean University
2015-2025
University of Pennsylvania
2017-2023
Chinese Academy of Fishery Sciences
2014-2023
Ministère de l'Agriculture et de la Souveraineté alimentaire
2023
Neijiang Normal University
2019-2023
Chongqing Medical University
2009-2021
Dalian Medical University
2021
Second Affiliated Hospital of Chongqing Medical University
2021
People’s Hospital of Rizhao
2021
Children's Hospital of Philadelphia
2018
The antifreeze glycoprotein-fortified Antarctic notothenioid fishes comprise the predominant fish suborder in isolated frigid Southern Ocean. Their ecological success undoubtedly entailed evolutionary acquisition of a full suite cold-stable functions besides protection. Prior studies adaptive changes these teleost generally examined single genotype or phenotype. We report here genome-wide investigations transcriptional and genomic associated with cold adaptation. sequenced characterized...
A fundamental challenge in understanding cardiac biology and disease is that the remarkable heterogeneity cell type composition functional states have not been well characterized at single-cell resolution maturing diseased mammalian hearts. Massively parallel single-nucleus RNA sequencing (snRNA-seq) has emerged as a powerful tool to address these questions by interrogating transcriptome of tens thousands nuclei isolated from fresh or frozen tissues. snRNA-seq overcomes technical isolating...
Abstract The anterior pituitary gland drives highly conserved physiologic processes in mammalian species. These hormonally controlled are central to somatic growth, pubertal transformation, fertility, lactation, and metabolism. Current cellular models of anteiror pituitary, largely built on candidate gene based immuno-histochemical mRNA analyses, suggest that each the seven hormones synthesized by is produced a specific exclusive cell lineage. However, emerging evidence suggests more complex...
Abstract Transcriptional plasticity is a major driver of phenotypic differences between species. The lower temperature limit (LTL), namely the end survival temperature, an important trait delimiting geographical distribution species, however, genetic mechanisms are poorly understood. We investigated inter-species transcriptional diversification in cold responses zebrafish Danio rerio and tilapia Oreochromis niloticus , which were reared at common (28 °C) but have distinct LTLs. identified...
Abstract Although the synaptic alterations associated with stress-related mood disorder major depression has been well-documented, underlying transcriptional mechanisms remain poorly understood. Here, we perform complementary bulk nuclei- and single-nucleus transcriptome profiling map locus-specific chromatin interactions in mouse neocortex to identify cell type-specific changes stress-induced behavioral maladaptation. We find that cortical excitatory neurons, layer 2/3 neurons particular,...
Hepcidin is a small bioactive peptide with dual roles as an antimicrobial and the principal hormonal regulator of iron homeostasis in human mouse. homologs very similar structures are found lower vertebrates, all comprise approximately 20-25 amino acids 8 highly conserved cysteines forming 4 intramolecular disulfide bonds, giving hepcidin hairpin structure. Hepcidins particularly diverse teleost fishes, which may be related to diversity aquatic environments varying degree pathogen challenge,...
The transcriptional programs of ectothermic teleosts are directly influenced by water temperature. However, the cis- and trans-factors governing cold responses not well characterized. We profiled changes in eight zebrafish tissues exposed to mildly severely temperatures using RNA-Seq. A total 1943 differentially expressed genes (DEGs) were identified, from which 34 clusters representing distinct tissue temperature response expression patterns derived k-means fuzzy clustering algorithm....
Abstract The mechanisms by which the eggs of Antarctic notothenioid fishes avoid freezing are not fully understood. Zona pellucida proteins (ZPs) constituents chorion forms a protective matrix surrounding egg. Here we report occurrence temperature-related gene expansion and acquisition unusual ice melting-promoting (IMP) activity in family ZPs (AnnotoZPs). Members AnnotoZPs shown to bind with non-colligatively depress melting point solution range 0.26 0.65 °C at moderate concentration. Eggs...
Temperature tolerance restricts the distribution of a species. However, molecular and cellular mechanisms that set thermal limits an organism are poorly understood. Here, we report on function dual-specificity phosphatase 1 (DUSP1) in regulation. Notably, found dusp1-/- zebrafish grew normally but survived within narrowed temperature range. The higher susceptibility these mutant fish to both cold heat challenges was attributed accelerated cell death caused by aggravated mitochondrial...
Abstract Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group neurodegenerative diseases, collectively known as tauopathies, that include Alzheimer’s disease (AD). The spreading misfolded “seeds” along neuronal networks is thought to play crucial role the progression pathology. Consequently, restricting release or uptake seeds may inhibit spread pathology and potentially halt advancement disease. Previous studies have demonstrated Mammalian Suppressor...
Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic sheep lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome 2357 individuals across 29 breeds worldwide, 4006 phenotypic related tail fat weight. We constructed first multi-tissue epigenome atlas terms elements, chromatin states, their functions explored utility elements interpreting...
Activation of the hypothalamic-pituitary-adrenal axis is considered to be one key physiological responses stress and, interestingly, shows a marked sex difference. Oestradiol plays an important role in this The present study investigated systemic and intrahypothalamic oestradiol response physical restraint female rats. We used jugular catheterisation microdialysis simultaneously measure plasma local concentrations paraventricular nucleus (PVN) hypothalamus. also assessed...
Abstract The Antarctic icefish, a family (Channichthyidae) of teleosts within the perciform suborder Notothenioidei, are only known vertebrates without oxygen‐transporting haemoglobins and that largely devoid circulating erythrocytes. To elucidate evo‐devo mechanisms underpinning suppressed erythropoiesis in we conducted comparative studies on transcriptomes micro RNA omes primary haematopoietic tissues between an icefish ( Chionodraco hamatus ) two red‐blooded notothenioids Trematomus...