A5069687620- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cellular transport and secretion
- Memory and Neural Mechanisms
- Pesticide Exposure and Toxicity
- Stress Responses and Cortisol
- Neurological Disorders and Treatments
- Epigenetics and DNA Methylation
- Computational Drug Discovery Methods
- Acute Ischemic Stroke Management
- Neuroendocrine regulation and behavior
- Marine Ecology and Invasive Species
- Radical Photochemical Reactions
- Retinoids in leukemia and cellular processes
- Physiological and biochemical adaptations
- Biological and pharmacological studies of plants
- Nephrotoxicity and Medicinal Plants
- Petroleum Processing and Analysis
- Advanced Glycation End Products research
- Renal and related cancers
- Signaling Pathways in Disease
- Chalcogenide Semiconductor Thin Films
Beijing Institute of Education
2024
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2024
University of Chinese Academy of Sciences
2009-2022
Daqing Oilfield of CNPC
2022
Guangxi University of Chinese Medicine
2021-2022
Institute of Psychology, Chinese Academy of Sciences
2018-2022
Daqing Oilfield General Hospital
2022
University of Southern California
2019-2021
Guangxi University
2021
Chinese Academy of Sciences
2008-2017
The antifreeze glycoprotein-fortified Antarctic notothenioid fishes comprise the predominant fish suborder in isolated frigid Southern Ocean. Their ecological success undoubtedly entailed evolutionary acquisition of a full suite cold-stable functions besides protection. Prior studies adaptive changes these teleost generally examined single genotype or phenotype. We report here genome-wide investigations transcriptional and genomic associated with cold adaptation. sequenced characterized...
The low-density lipoprotein receptor–related protein 1 (LRP1) is an endocytic and cell signaling transmembrane protein. Endothelial LRP1 clears proteinaceous toxins at the blood–brain barrier (BBB), regulates angiogenesis, increasingly reduced in Alzheimer’s disease associated with BBB breakdown neurodegeneration. Whether loss of endothelial plays a direct causative role neurodegenerative changes remains elusive. Here, we show that inactivation from mouse endothelium results progressive...
Abstract The endosomal trafficking pathways are essential for many cellular activities. They also important targets by intracellular pathogens. Key regulators of the include retromer complex and sorting nexins (SNXs). Chlamydia trachomatis effector protein IncE directly components SNX5 SNX6 suppresses retromer-mediated transport, but exact mechanism has remained unclear. We present crystal structure PX domain in with IncE, showing that binds to a highly conserved hydrophobic groove SNX5....
Abstract Background MicroRNAs (miRNAs) play important roles in regulating the expression of protein-coding genes by directing degradation and/or repression translation gene transcripts. Growing evidence shows that miRNAs are indispensable player organismal development with its regulatory role growth and differentiation cell lineages. However, miRNA-mediated regulation environmental adaptation organisms largely unknown. To examine this potential capability, we characterized microRNAomes from...
Subcortical white matter (WM) stroke accounts for 25% of all strokes and is the second leading cause dementia. Despite such clinical importance, we still do not have an effective treatment ischemic WM stroke, mechanisms postischemic neuroprotection remain elusive. 3K3A-activated protein C (APC) a signaling-selective analogue endogenous blood protease APC that currently in development as neuroprotectant patients. Here, show 3K3A-APC protects tracts oligodendrocytes from injury corpus callosum...
Structural and functional alterations in brain microvascular endothelial cells (BMECs) caused by oxygen-glucose deprivation (OGD) are involved the pathogenesis of various disorders. AlkB homolog 5 (ALKBH5) is a primary m6A demethylase that regulates cell processes, but its distinct roles BMEC function remain to be clarified. In present study, mouse middle cerebral artery occlusion (MCAO) model, knockout ALKBH5 reduced neurological deficits, infarct volumes tissue apoptosis...
SUMMARY Cephalochordates, urochordates, and vertebrates comprise the three extant groups of chordates. Although higher morphological developmental similarity exists between cephalochordates vertebrates, molecular phylogeny studies have instead suggested that morphologically simplified urochordates are closest relatives to vertebrates. MicroRNAs (miRNAs) regarded as major factors driving increase complexity in early vertebrate evolution, extensively characterized a few species urochordates....
SNX6 is a ubiquitously expressed PX-BAR protein that plays important roles in retromer-mediated retrograde vesicular transport from endosomes. Here we report CNS-specific Snx6 knockout mice exhibit deficits spatial learning and memory, accompanied with loss of spines distal dendrites hippocampal CA1 pyramidal cells. interacts Homer1b/c, postsynaptic scaffold crucial for the synaptic distribution other density (PSD) proteins structural integrity dendritic spines. We show functions...
Self-renewal and differentiation are the hallmarks of embryonic stem cells (ESCs). However, it is largely unknown about how pluripotency regulated. Here we demonstrate that Pcid2 required for maintenance self-renewal both in mouse human ESCs. plays a critical role suppression ESC differentiation. deficiency causes early lethality before blastocyst stage. associates with EID1 present CBP/p300-EID1 complex We show MDM2 an E3 ligase K48-linked ubiquitination its degradation. For self-renewal,...
An 8-week feeding trial was carried out using young hybrid sturgeon (♀Huso huso × ♂Acipenser schrenckii) to study the effects of dietary phosphorus (P) on growth performance, body composition, liver and serum antioxidant status as well effluent P content in wintertime. Four puffed pellet diets were formulated contain graded total levels at 0.63, 1.15, 1.85, 2.12%, respectively. Triplicate groups (494.21 ± 18.63 g) reared concrete ponds (2.0 1.2 1.4 m), fed one four for 8 weeks. Weight gain...
The electric field response of lead sulfide (PbS) quantum dots with near-infrared absorption 1000–1600 nm (corresponding to diameters 2–5 nm) embedded in a PMMA film has been systematically studied by using modulation spectroscopy. For all PbS samples, the electroabsorption spectra across first and second exciton bands are similar shape derivative spectra, indicating enhancement dipole moment following optical transition these bands. analysis shows that moments for both increase little bit...
The electronic structure and elastic properties of the ternary layered carbide V3GeC2 were investigated by first-principle plane-wave pseudopotential total energy calculation method based on density functional theory. It is found that computed P63/mmc lattice constants internal coordinates are a = 2.9636?, c 17.2256? zV2 0.1325, zC 0.5712, respectively. predictable cohesive reflects it could be stable Mn+1AXn phase like Ti3GeC2 V2GeC, while band shows has anisotropic electrical conductivity,...
Purpose: To determine the molecular mechanism involved in anti-migraine effect of Asari Radix et Rhizoma (ARR) using network pharmacology.
 Methods: The compounds present ARR were identified through information retrieval from literature and public databases, screened based on absorption, distribution, metabolism, excretion toxicity. Target genes related to selected migraine or predicted databases. Hub against analysis interactions overlapping between target genes, STRING database. Gene...