A5101926840- Astrophysical Phenomena and Observations
- CCD and CMOS Imaging Sensors
- Lung Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Pulsars and Gravitational Waves Research
- Fluid Dynamics and Turbulent Flows
- Calibration and Measurement Techniques
- Circular RNAs in diseases
- Adaptive optics and wavefront sensing
- Bioactive Compounds and Antitumor Agents
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Particle Detector Development and Performance
- Wind and Air Flow Studies
- Stroke Rehabilitation and Recovery
- Aerodynamics and Acoustics in Jet Flows
- Cerebrovascular and Carotid Artery Diseases
- Microtubule and mitosis dynamics
- Astrophysics and Cosmic Phenomena
- Neuroinflammation and Neurodegeneration Mechanisms
- Enhanced Oil Recovery Techniques
- Traditional Chinese Medicine Analysis
- Lung Cancer Treatments and Mutations
- Advanced Sensor and Control Systems
- Pharmacological Effects of Natural Compounds
Institute of High Energy Physics
2014-2024
Chinese Academy of Sciences
2010-2024
Weatherford College
2024
Fudan University
2024
Shanghai Research Center for Acupuncture and Meridians
2024
Institute of Mechanics
2023-2024
Binzhou Medical University
2018-2024
Shandong First Medical University
2023-2024
Zhengzhou Central Hospital
2024
Nanjing University of Aeronautics and Astronautics
2024
Imperatorin, an active ingredient extracted from Angelica and Qianghuo, has anti-inflammatory, anti-oxidative stress damage, blocking calcium channels, other properties. Our preliminary findings revealed the protective role of imperatorin in treatment vascular dementia, we further explored underlying mechanisms concerning neuroprotection function dementia. The cobalt chloride (COCl2)-induced chemical hypoxia hypoglycemia hippocampal neuronal cells was applied as vitro dementia model. Primary...
Abstract Background The impact of triglyceride-glucose (TyG) index, a surrogate marker for insulin resistance, on the risk cardiovascular disease (CVD) in general populations remains controversial. We aimed to comprehensively study relationship between TyG index with incident CVD events population Shanghai. Methods A total 42,651 participants without previous history from Shanghai Suburban Adult Cohort and Biobank (SSACB) were included. SSACB was community-based natural cohort using...
Unfractionated heparin (UFH), a linear polysaccharide, is the gold-standard agent to overcome blood coagulation. Excess UFH frequently produces severe adverse impacts, and an additional neutralizer should be administrated immediately reverse heparinization. Here, reversal strategy developed through entire encapsulation by giant macrocyclic neutralizers. Two cationic large-sized macrocycles, quaternary ammonium-functionalized quaterphen[3]arene (CQP3) pentaphen[3]arene (CPP3), are designed...
Salvianolic acid A (SAA), one of the major active components Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims investigate cardioprotection SAA vivo vitro using model myocardial ischemia-reperfusion rat hydrogen peroxide (H(2)O(2))-induced H9c2 cardiomyoblasts apoptosis. It was found significantly limited infarct size ischemic myocardium when given immediately prior reperfusion. also...
Aim Based on the ageing population and inadequate healthcare system in China, majority of care for patients with Alzheimerʼs disease (AD) is provided by family caregivers. Caregivers suffer a long‐term heavy burden pressure, which affects their physical mental health. The present study aims at investigating health‐related quality life (HRQOL) among caregivers AD exploring its influencing factors. Methods This included 206 (76 male, 130 female) recruited from one Tier 3 hospital, psychiatric...
Abstract In view of the complicated pathophysiological process vascular dementia (VD), drugs for clinical treatment VD mainly target related risk factors, while with excellent efficacy in cognitive function are still relatively lacking. Imperatorin (IMP), an active constituent extracted from angelica dahuricae and notopterygium Notopterygii, which has anti-inflammatory, vasodilator, anticoagulant, block calcium channel, anticonvulsant, anti oxygen free radical injury properties....
Chronic stress exposure induces maladaptive behavioral responses and increases susceptibility to neuropsychiatric conditions. However, specific neuronal populations circuits that are highly sensitive trigger remain be identified. Here we investigate the patterns of spontaneous activity proopiomelanocortin (POMC) neurons in arcuate nucleus (ARC) hypothalamus following chronic unpredictable (CUS) for 10 days, a paradigm used induce deficits such as anhedonia despair [1, 2]. CUS increased...
Epidermal growth factor receptor (EGFR) mutations occur in up to 50% of Asian patients with non-small cell lung cancer (NSCLC). Treatment advanced NSCLC EGFR-tyrosine kinase inhibitor (EGFR-TKI) confers a significant survival benefit. This study assessed the efficacy and safety chemotherapy or without icotinib undergoing resection stage IB ⅢA EGFR-mutated NSCLC.Patients surgically resected (with high risk factors) were randomly assigned (1:1) one two treatment plans. One group received four...
Here, we designed composites of neutrophils and NIR-sensitive nanoparticles (NSNP@Ne) to eradicate pancreatic tumors inhibit tumor recurrence.
Successful deployment of geological carbon storage (GCS) requires an extensive use reservoir simulators for screening, ranking and optimization sites. However, the time scales GCS are such that no sufficient long-term data is available yet to validate against. As a consequence, there currently solid basis assessing quality with which dynamics large-scale operations can be forecasted. To meet this knowledge gap, we have conducted major validation benchmark study. achieve reasonable scales,...
AIM:To evaluate the therapeutic effect of hydroxynaphthoquinone mixture (HM) on dextran sulfate sodium (DSS)-induced colitis and explore underlying mechanisms.METHODS: BALB/c mice received 3.5% DSS for 6 d to induce ulcerative colitis.Groups were orally administered HM 3.5, 7 14 mg/kg mesalazine 200 per day d.During experiment, clinical signs body weight, stool consistency visible fecal blood monitored recorded daily.A disease activity index score was calculated each animal.At conclusion...
•Ex vivo liver perfusion stimulates hepatocytes to re-enter the cell cycle.•Flow-induced shear stress induces hepatocyte proliferation in vitro.•β1 integrin-YAP mechanotransduction is essential for shear-enhanced proliferation. Background & AimsLiver paracrine signaling from sinusoid endothelial cells response mechanical stimuli crucial highly coordinated regeneration. Interstitial flow through fenestrated endothelium inside space of Disse potentiates role direct exposure fluid immediate...
Objective To investigate the influence of acupuncture lifting-thrusting frequency and amplitude on analgesic effects, its correlation with mast cell degranulation. Methods Acute adjuvant arthritis (AA) rat models were employed. Robot-arm aided therapy was conducted various frequencies (ranging from 0.5 to 4 Hz) amplitudes 2.0 mm). The rats’ pain thresholds measured multiple times before after therapy, effects evaluated using threshold recovery rate (PTRR), a normalized index. degranulation...
The shark-skin-inspired riblets could effectively reduce the turbulence wall-skin friction compared with smooth surface. Nevertheless, computations of flow field over in practical configurations (e.g., airplanes and wind turbines) remain unfeasible for its huge computational cost. In this study, a general strategy modelling effects turbulent flows is proposed. Riblets are modelled by adopting slip-boundary condition on wall. A quantitative relationship between riblet geometric parameters...
Riblet is one of the most promising passive drag reduction techniques in turbulent flows. In this paper, hot-wire measurements on a boundary layer perturbed by drag-reducing riblet surface are carried out to further understand effects flows and mechanism. Compared with smooth case, different energy variations near-wall region logarithmic observed over riblets. Then, using spectral filter given wavelength, time series data decomposed into large- small-scale components. It indicated that...
The Follow-up X-ray Telescope (FXT), a key payload onboard the Einstein Probe sallite (EP), is equipped with Wolter-I x-ray focusing mirror system. We introduce principle of such system and analyze influence gap in multishell nested FXT on effective area, stray-light ratio, vignetting. To ensure that no occlusion occurs within adjacent shells minimize size set to optimized value for corresponding shell. finished design 54-shell according these results. optical performance was then simulated...
Charged Coupled Devices (CCDs) have been successfully used in several low energy X-ray astronomical satellites over the past two decades. Their high resolution and spatial make them a perfect tool for astronomy, such as observing formation of galaxy clusters environment around black holes. The Low Energy Telescope (LE) group is developing Swept Charge Device (SCD) Hard Modulation (HXMT) satellite. A SCD special CCD, which can be read out thousand times faster than traditional CCDs,...
The Low Energy X-ray Instrument (LE) of the Hard Modulation Telescope (HXMT) uses Swept Charge Device (SCD) to detect X-rays in 1−15 keV. performance SCD is vulnerable temperature. We analyzed thermal condition LE at different satellite working attitudes with Finite Element Method (FEM). It shown that angle between sunlight and normal line barrier should be less than 26°, keep detectors required temperature range, i.e. −40 °C −80 °C. find very stable this a typical energy resolution 160 eV 5.9