A5100710563- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Endometrial and Cervical Cancer Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Monoclonal and Polyclonal Antibodies Research
- Pharmacogenetics and Drug Metabolism
- Genetic and Kidney Cyst Diseases
- Spinal Dysraphism and Malformations
- Breast Cancer Treatment Studies
- Renal and related cancers
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Lymphatic System and Diseases
- Chemical Reactions and Isotopes
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Connective tissue disorders research
- Galectins and Cancer Biology
- Diagnosis and Treatment of Venous Diseases
- Advanced X-ray and CT Imaging
- RNA Interference and Gene Delivery
- Cervical Cancer and HPV Research
Shanghai East Hospital
2012-2022
Tongji University
2013-2021
Daiichi Sankyo (United States)
2013
Osteogenic suppressors such as Sclerostin not only regulate skeletal development and regeneration but also serve anti-osteoporosis drug targets. However, very few druggable have been identified due to limited understanding of the molecular mechanisms governing osteogenesis. Here, we show that fibroblast activation protein (Fap), a serine protease inhibited by bone growth factor Osteolectin, is an osteogenic suppressor. Genetic deletion Fap significantly ameliorates limb trabecular loss...
Here, we designed composites of neutrophils and NIR-sensitive nanoparticles (NSNP@Ne) to eradicate pancreatic tumors inhibit tumor recurrence.
Although diffusion tensor imaging has been successfully applied in brain research for decades, several main difficulties have hindered its extended utilization spinal cord imaging.To assess the feasibility and clinical value of tractography evaluating chronic compression.Single-shot spin-echo echo-planar DT sequences were scanned 42 compression patients 49 healthy volunteers. The mean values apparent coefficient fractional anisotropy measured region interest at cervical lower thoracic cord....
The aim of the study was to investigate value mean apparent diffusion coefficient (ADC(mean)) in predicting prognosis stage IB-IIA cervical squamous cell carcinoma (SCC) patients after radical hysterectomy.A total 126 who were with SCC and underwent magnetic resonance imaging examination hysterectomy retrospectively investigated. Receiver operating characteristic curve used determine cutoff values ADC(mean) for earlier recurrence (2 consecutive increases antigen more than 1 ng/mL or...
Abstract Background MicroRNAs (miRNAs) are important regulators for cancer cell proliferation. miR-585 has been shown to inhibit the proliferation of several types cancer, however, little is known about its role in human glioma cells. Methods levels clinical samples and lines were examined by quantitative real-time PCR (qRT-PCR) analysis. Cell was measured Counting Kit-8 (CCK-8) EdU incorporation assays vitro. For vivo investigations, U251 cells intracranially inoculated BALB/c nude mice...
Primary cilia influence cell function and tissue development. Ciliary signaling is mediated by two intraflagellar transport (IFT) protein complexes, IFT-A IFT-B. The complex responsible for retrograde transport, IFT140 a core in the A complex. Mutations cause variety of skeletal disorders. However, expression role during bone development remain unclear. In this study, to further explore potential osteogenesis, we used lineage tracing conditional knockout analyze distribution IFT140-positive...
Purpose To assess the function of inguinal lymph node (ILN) in low extremity lymphedema (LEL) with dynamic enhanced MR lymphangiography (MRL). Materials and Methods Sixty‐four patients clinically diagnosed LEL underwent MRL examinations. The drainage patterns were separated into four subtypes. peak time to enhancement contrast ratio ILN calculated 35 min following agent administration. Results Dilated lymphatic vessels could be observed all subjects. Type I–IV 25% (16/64), 45.31% (29/64),...
The development of multifunction nanoplatforms integrating accurate diagnosis and efficient therapy is great significance for the precise treatment tumors. Gold nanoparticles (AuNPs) possessing hallmark features computed tomography (CT) imaging photothermal conversion capability hold potential in tumor theranostics. In this study, taking advantages outstanding biocompatibility, interesting anti-inflammatory immunomodulatory properties, abundant amino acid residues silk fibroin (SF), a...
BackgroundDiffusion-weighted imaging (DWI) is a functional modality that indirectly represents the biological characteristics of cancer. However, correlation apparent diffusion coefficients (ADCs) to HPV type in patients with cervical cancer still unknown. PurposeTo explore relationship between calculated by DW-magnetic resonance (MRI) and high-risk human papilloma virus (HR-HPV) infection squamous cell carcinoma (CSCC) patients. Material MethodsA total 315 histologically proven CSCC who...
The aim of this study was to investigate the relationship between various patient-related factors (physical and cardiac hemodynamic parameters) coronary artery density on CT angiography (CCTA).A total 64 patients (female: male ratio, 24:40; age, 58.2 years±9.3, age range, 31-81 years; mean body weight, 65.3 kg±11.6, range 40-88 kg) were effectively enrolled in approved retrospective study. Patient-related physical including height, weight (BW), mass index (BMI), systolic blood pressure...
Abstract Background: Tivantinib (ARQ197) is an orally administered cMET inhibitor currently under development as a cancer therapy. Nonclinical studies have indicated that tivantinib and its major metabolites the potential to inhibit cytochrome P450 (CYP) 3A4, 2C19, 2C9, 1A, P-glycoprotein (P-gp) at clinical concentrations being studied in phase 3 studies. The objective of this drug interaction study was assess effect steady state levels on pharmacokinetics CYP- P-gp-specific probe drugs...