A5101960602- Particle accelerators and beam dynamics
- Particle Accelerators and Free-Electron Lasers
- Magnetic confinement fusion research
- Plasma Diagnostics and Applications
- Ion-surface interactions and analysis
- Nuclear Physics and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Electron and X-Ray Spectroscopy Techniques
- Stress Responses and Cortisol
- Gyrotron and Vacuum Electronics Research
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Mass Spectrometry Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Fusion materials and technologies
- Superconducting Materials and Applications
- Plant nutrient uptake and metabolism
- Plant Molecular Biology Research
- Advanced biosensing and bioanalysis techniques
- Atomic and Molecular Physics
- Adipose Tissue and Metabolism
- Congenital heart defects research
- Petroleum Processing and Analysis
- Electrochemical Analysis and Applications
- Solar-Powered Water Purification Methods
Institute of Modern Physics
2012-2024
Chinese Academy of Sciences
2012-2024
Henan University
2024
University of Chinese Academy of Sciences
2013-2022
Center for Excellence in Molecular Plant Sciences
2018-2022
Augusta University
2019-2022
Soochow University
2014-2020
First Affiliated Hospital of Anhui Medical University
2020
Anhui Medical University
2020
Nanjing Drum Tower Hospital
2019
Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, is a key regulator of cellular metabolism. Recent genome-wide association studies identified genetic variants SIRT1 linked to major depressive disorders. widely expressed in the brain; however, neuronal substrates that mediate action on behaviors remain largely unknown. Here we show selective deletion forebrain excitatory neurons causes depression-like phenotypes male but not female mice. AAV-Cre-mediated knockdown medial prefrontal cortex...
Post-traumatic stress disorder (PTSD) is characterized by exaggerated fear expression and impaired extinction. The underlying molecular cellular mechanisms of PTSD are largely unknown. current pharmacological non-pharmacological treatments for either ineffective or temporary with high relapse rates. Here we report that adiponectin-deficient mice exhibited normal contextual conditioning but displayed slower extinction learning. Infusions adiponectin into the dentate gyrus (DG) hippocampus in...
Abstract Previous studies have shown that AgRP neurons in the arcuate nucleus (ARC) respond to energy deficits and play a key role control of feeding behavior metabolism. Here, we demonstrate chronic unpredictable stress, an animal model depression, decreases spontaneous firing rates, increases irregularity alters properties both male female mice. These changes are associated with enhanced inhibitory synaptic transmission reduced intrinsic neuronal excitability. Chemogenetic inhibition...
Detached Arabidopsis thaliana leaves can regenerate adventitious roots, providing a platform for studying de novo root regeneration (DNRR). However, the comprehensive transcriptional framework of DNRR remains elusive. Here, we provide high-resolution landscape transcriptome reprogramming from wound response to organogenesis in and show key factors involved DNRR. Time-lapse RNA sequencing (RNA-seq) entire leaf within 12 h detachment revealed rapid activation jasmonate, ethylene, reactive...
Chronic stress exposure induces maladaptive behavioral responses and increases susceptibility to neuropsychiatric conditions. However, specific neuronal populations circuits that are highly sensitive trigger remain be identified. Here we investigate the patterns of spontaneous activity proopiomelanocortin (POMC) neurons in arcuate nucleus (ARC) hypothalamus following chronic unpredictable (CUS) for 10 days, a paradigm used induce deficits such as anhedonia despair [1, 2]. CUS increased...
A new project, high intensity heavy ion accelerator facility (HIAF), is currently under design and construction in China. The HIAF front end, composed of electron cyclotron resonance (ECR) sources, low energy beam transport (LEBT) radio frequency quadrupole (RFQ), will produce provide beams ions with a mass up to uranium at $0.5\text{ }\text{ }\mathrm{MeV}/\mathrm{u}$. typical designed 2 emA for the charge state $35+$. This paper presents an overall end discusses several key issues design....
Germacrone, a monocyclic sesquiterpene, exerts marked antitumor effects in variety of cancers, including hepatocellular carcinoma, gastric cancer, and breast cancer. However, the mechanism underlying germacrone on cancer remains unclear. In this study, we show that inhibited cell proliferation dose-dependent manner, induced G0/G1-phase cycle arrest apoptosis these cells. Moreover, increased expression LC3II/LC3I. And LC3II/LC3I was significant after treatment compared with bafilomycin A1...
At Institute of Modern Physics (IMP), Chinese Academy Sciences (CAS), the superconducting Electron Cyclotron Resonance (ECR) ion source SECRAL (Superconducting ECR with Advanced design in Lanzhou) has been put into operation for about 10 years now. It main working horse to deliver intense highly charged heavy beams accelerators. Since its first plasma at 18 GHz, R&D work towards more beam production as well quality investigation never stopped. When was upgraded typical frequency 24 it...
Ion source development over the last 20 years at IMP is reviewed. For versatile purposes, several types of ion sources have been involved in research and work IMP, i.e., highly charged ECR (Electron Cyclotron Resonance) source, intense microwave or 2.45 GHz beam laser (LIS). In sources, SECRAL (Superconducting with Advanced design Lanzhou), Lanzhou all permanent magnet series made, which can cover operation frequency range 10-28 GHz. The LIS an Nd:YAG a maximum output energy 8 J ns pulse...
Isoflurane and sevoflurane are both inhalation anesthetics, but in clinical application, has been considered to be less suitable for long-term anesthesia because of its catabolic compounds potential nephrotoxicity. Nevertheless, recent studies have shown that these two anesthetics similar hepatorenal toxicity, cost, anesthetic effect. Moreover, possibly cognitive impact on young mice. In this study, C57BL/6 mice aged 8-10 weeks were exposed 1.2% isoflurane or 2.4% 6 hours. Cognitive function...
Experimental evidence of the property transverse coupling beam from Electron Cyclotron Resonance (ECR) ion source is presented. It especially interest for an ECR source, where cross section extracted not round along transport path due to magnetic confinement configuration. When ions are and accelerated through descending axial field at extraction region, horizontal vertical phase space strongly coupled. In this study, configuration between spaces achieved by back-tracking simulation based on...
LECR4 (Lanzhou ECR ion source No. 4) is a room temperature electron cyclotron resonance source, designed to produce high current, charge state beams for the SSC-LINAC injector (a new sector separated cyclotron) at Institute of Modern Physics. also serves as PoP machine application evaporative cooling technology in accelerator field. To achieve those goals, has been optimized operation 18 GHz. During 2014, was commissioned GHz microwave 1.6 kW. further study influence injection stage...
Ion beam transport from the Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou (SECRAL) electron cyclotron resonance was studied at Institute of Modern Physics during 2010. Particle-in-cell simulations and experimental results have shown that both space charge magnetic aberrations lead to a larger envelope emittance growth. In existing SECRAL extraction line, it has been raising solenoid lens field reduces subsequent dipole lower emittance. Detailed...
LECR4 (Lanzhou electron cyclotron resonance ion source No. 4) has been successfully constructed at IMP and also connected with the Low Energy Beam Transport (LEBT) Radio Frequency Quadrupole (RFQ) systems. These magnet coils are cooled through evaporative cooling technology, which is first attempt an ECR in world. The maximum mirror field 2.5 T (with iron plug) effective plasma chamber volume 1.2 l. It was designed to be operated 18 GHz aimed produce intense multiple charge state heavy beams...
A new room temperature electron cyclotron resonance (ECR) ion source, DRAGON, is under construction at IMP. DRAGON designed to operate microwaves of frequencies 14.5–18 GHz. Its axial solenoid coils are cooled with evaporative medium provide an magnetic mirror field 2.5 T the injection and 1.4 extraction, respectively. In comparison other conventional ECR sources, has so far largest bore plasma chamber inner diameter 126 mm maximum radial fields 1.4–1.5 produced by a non-Halbach permanent...
A laser (Nd:YAG laser, 3 J, 1064 nm, 8–10 ns) ion source has been built and under development at IMP to provide pulsed high-charge-state heavy beams a radio frequency quadrupole (RFQ) for upgrading the accelerators with new low-energy beam injector. The currently operates in direct plasma injection scheme inject high charge state ions produced from solid target into RFQ. maximum power density on was about 8.4 × 1012 W/cm2. preliminary experimental results will be presented discussed this paper.
Sleep-wake rhythm disturbances, which are characterized by abnormal sleep timing or duration, associated with cognitive dysfunction. Photoacoustic treatments including light and sound stimulation have been found to be effective in modulating patterns improving behavior sleep-wake pattern experiments. In this study, we examined whether interventions could reduce disturbances memory deficits a disturbance model. We established model of C57BL/6J mice via deprivation method involving manual cage...
Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou (SECRAL) is an advanced fully superconducting ECR at IMP designed to be operational the microwave frequency of 18–24 GHz. The existing SECRAL beam transmission line composed a solenoid lens and 110° analyzing magnet. Simulations particle tracking 3D space charge effect realistic magnetic fields through were performed using particle-in-cell code. results dynamics show that such low energy very sensitive...