A5016243517- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Advanced Battery Technologies Research
- Cancer, Lipids, and Metabolism
- Birth, Development, and Health
- Advanced Battery Materials and Technologies
- Geophysics and Gravity Measurements
- GNSS positioning and interference
- Advancements in Battery Materials
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Ionosphere and magnetosphere dynamics
- Insect symbiosis and bacterial influences
- Cancer, Hypoxia, and Metabolism
- Pain Mechanisms and Treatments
- Telomeres, Telomerase, and Senescence
- Invertebrate Immune Response Mechanisms
- Cardiomyopathy and Myosin Studies
- Asthma and respiratory diseases
Women's Hospital, School of Medicine, Zhejiang University
2020-2024
Qingdao University
2020-2024
Capital Medical University
2024
Qingdao Municipal Hospital
2022-2023
Memorial Sloan Kettering Cancer Center
2015-2023
iQIYI (China)
2020-2023
Yuhuangding Hospital
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2003-2022
Huazhong University of Science and Technology
2004-2020
Qingdao Academy of Intelligent Industries
2020
Abstract Autophagy is a cellular catabolic process critical for cell viability and homoeostasis. Inhibition of mammalian target rapamycin (mTOR) complex-1 (mTORC1) activates autophagy. A puzzling observation that amino acid starvation triggers more rapid autophagy than pharmacological inhibition mTORC1, although they both block mTORC1 activity with similar kinetics. Here we find in addition to inactivation, also causes an increase phosphatase towards ULK1, substrate whose dephosphorylation...
Objective To investigate the function of ATPase Na+/K+ Transporting Subunit Beta 3 (ATP1B3) in gliomas and molecular mechanisms associated with them order to identify a novel target approach for glioma clinical diagnosis treatment. Methods The Cancer Genome Atlas (TCGA), public tumor database, Chinese Glioma (CGGA) were used evaluate differential expression ATP1B3 cells various grades. Its connection patient survival prognosis; siRNA interference instantly reduced amount cell lines U87MG...
Overdischarge often occurs during the use of battery packs, owing to cell inconsistency in pack. In this study, overdischarge behavior 2.9 Ah cylindrical NCM811 [Li(Ni0.8Co0.1Mn0.1)O2] batteries an adiabatic environment was investigated. A higher rate resulted a faster temperature increase batteries. Moreover, following temperatures increased: Tu, at which voltage decreased 0 V; Ti, current A; and maximum (Tm). The times decreased: tu, when from 3 V, ti, A. discharge capacity 3.06–3.14 Ah,...
Background: Aloin, as a bioactive compound, has variety of pharmacological functions, but its effects on combined allergic rhinitis and asthma syndrome (CARAS) have not been studied. To clarify the protective effect mechanism aloin in treatment CARAS by network pharmacology, molecular dynamics simulation experiment. Methods: The targets aloin, were obtained from various databases. protein interaction was constructed for common targets, docking simulations performed core targets. Functional...
Frequent accidents involving Li-ion batteries have prompted higher safety requirements for these batteries. In this study, the high-temperature, thermal runaway (TR) characteristic parameters at 100% state of charge (SOC) cylindrical NCM811 with a high-energy density were compared to widely commercialized NCM523 The average TR trigger temperature battery was 157.54°C, which 20.62°C lower than that NCM523. Moreover, maximum is 858.22°C, 212.81°C 1289.53°C. high Ni exhibited poor stability and...
Background: The primary factor of cancer mortality is lung tumor. ABI3BP gene encodes an extracellular matrix bind protein associated to multiplication and derivation. However, the prognosis score for tumor its relation with immunity cellular infiltration have not been reported. Methods: Public repository systems (Timer, GEPIA, TCGA, HPA) were utilized explore expression tumor, explored clinicopathological parameters. TCGA information set was cox analysis data one or more variables STRING...
Structural and functional alterations in brain microvascular endothelial cells (BMECs) caused by oxygen-glucose deprivation (OGD) are involved the pathogenesis of various disorders. AlkB homolog 5 (ALKBH5) is a primary m6A demethylase that regulates cell processes, but its distinct roles BMEC function remain to be clarified. In present study, mouse middle cerebral artery occlusion (MCAO) model, knockout ALKBH5 reduced neurological deficits, infarct volumes tissue apoptosis...
The purpose of this study was to explore the application value lncRNA MEG3 in lung cancer. From March 2017 2019, 119 asthma patients and 125 healthy people undergoing physical examination same period were selected as research objects. levels peripheral blood two groups compared, predictive for well differences different inflammatory phenotypes analyzed. expression low (P<0.050), diagnostic sensitivity specificity 79.83 66.40%, respectively (P<0.001), it lowest mixed granulocytic (P<0.050)...
Macroautophagy/autophagy, a stress-responsive cellular survival mechanism, plays important and context-dependent roles in cancer, its inhibition has been implicated as promising cancer therapeutic approach. The detailed mechanisms underlying the function of autophagy have not fully understood. In this study, we show that promotes both efficacy chemotherapy for treatment glioblastoma (GBM) therapy-induced senescence GBM cells. As specific cell fate characterized by permanent cycle arrest, is...
Objective ABI Family Member 3 Binding Protein (ABI3BP) is an extracellular matrix protein that affects the carcinogenesis of lung and esophageal cancer. However, relevance ABI3BP in different forms cancer uncertain. Methods expression was interpreted using Cancer Genome Atlas (TCGA) database, Genotype Tissue Expression (GTEx) Human (HPA) Cell Line Encyclopedia (CCLE) immunohistochemistry. The R programming language used to analyze association between patient prognosis evaluate relationship...
While hundreds of consistently altered autophagy-related genes (ARGs) have been identified in cancers, their prognostic value bladder urothelial carcinoma (BUC) remains unclear. In the present study, we collected 232 ARGs from Human Autophagy Database (HADb), and 37 differentially expressed BUC based on The Cancer Genome Atlas (TCGA) database. Kaplan-Meier survival analysis Gene Expression Profiling Interactive Analysis (GEPIA) database revealed that among ARGs, prolyl 4-hydroxylase, beta...