A5100424943- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Dementia and Cognitive Impairment Research
- Immune cells in cancer
- Pluripotent Stem Cells Research
- Venomous Animal Envenomation and Studies
- Environmental and Agricultural Sciences
- Hair Growth and Disorders
- Mathematical Biology Tumor Growth
- Advanced Neuroimaging Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Histone Deacetylase Inhibitors Research
- Neurological Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Neonatal and fetal brain pathology
- dental development and anomalies
- Cancer Research and Treatments
- Mast cells and histamine
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Biofield Effects and Biophysics
Institute of Biophysics
2013-2024
Chinese Academy of Sciences
2007-2024
Beijing Biocytogen (China)
2024
Taichung Veterans General Hospital
2023
Computer Network Information Center
2023
Beijing University of Chinese Medicine
2022
Nanjing Forestry University
2022
Guangxi University
2021
Guangxi University of Chinese Medicine
2021
Chinese National Human Genome Center
2019
Abstract The existence of bladder cancer stem cells (BCSC) has been suggested to underlie tumor initiation and recurrence. Sonic Hedgehog (SHH) signaling implicated in promoting cell (CSC) self-renewal is activated cancer, but its impact on BCSC maintenance unclear. In this study, we generated a mAb (BCMab1) against CD44+ human that recognizes aberrantly glycosylated integrin α3β1. combination BCMab1 with an anti-CD44 antibody identified BCMab1+CD44+ subpopulation as BCSCs cell–like...
Cancer stem cells (CSCs) are considered one of the key contributors to chemoresistance and tumor recurrence. Therefore, precise identification reliable CSC markers clarification intracellular signaling involved in CSCs remains a great challenge fields relating cancer biology. Here, we implemented novel chemoresistant prostate patient-derived xenograft (PDX) model NOD/SCID mice identified CD54 as candidate gene among most highly enriched expression profiles tumors exposed chronic cisplatin...
Abstract Androgen receptor (AR) signaling may promote renal cell carcinoma (RCC) progression via altered HIF-2α/VEGF signaling. However, it remains unclear whether AR also promotes RCC by recruiting vascular endothelial cells (ECs), key players in the development of blood vessels. In our study, increased EC proliferation and recruitment to tumor microenvironment promoted progression. Mechanistically, modulated cytokine CXCL5 expression altering AKT → NF-κB signaling, interruption using...
Sertoli cells are the most important somatic contributing to microenvironment (named niche) for spermatogonial stem (SSCs). They produce amounts of crucial growth factors and structure proteins that play essential roles in complex processes male SSCs survival, proliferation, differentiation. It has been suggested cell abnormalities could result spermatogenesis failure, eventually causing azoospermia humans. However, end, gene expression characteristics protein functions human remained...
Abstract Background The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance cisplatin. Increasing evidence has revealed the implication stem cells in development chemoresistance. However, underlying molecular mechanisms remain be elucidated. This study investigates role LASS2, a ceramide synthase, regulating Wnt/β-catenin signaling subset stem-like and explores strategies sensitize cisplatin treatment....
Self-renewal and differentiation are the hallmarks of embryonic stem cells (ESCs). However, it is largely unknown about how pluripotency regulated. Here we demonstrate that Pcid2 required for maintenance self-renewal both in mouse human ESCs. plays a critical role suppression ESC differentiation. deficiency causes early lethality before blastocyst stage. associates with EID1 present CBP/p300-EID1 complex We show MDM2 an E3 ligase K48-linked ubiquitination its degradation. For self-renewal,...
Bladder cancer is one of the most common malignancies. The existence bladder stem cells (BCSCs) has been suggested to underlie tumor initiation and recurrence. Propofol a commonly used intravenous anesthetic. Here, we find that propofol can dramatically block activation Hedgehog pathway in BCSCs. strongly repressed growth cells. Attenuated proliferation enhanced apoptosis were observed upon stimulation. Furthermore, reduced self-renewal ability BCSCs as well formation. In conclusion,...
Abstract Tumor recurrence is still a major challenge for clinical treatment of bladder cancer. Cumulative evidences indicate cancer stem cells ( CSC s) contribute to drug resistance and leave putative source disease relapse. Identifying novel agents targeting s may represent new paradigm in the therapy Here, we separated hedgehog (Hh) inhibitor, iG 2, from treptomyces roseofulvus , which dramatically blocked activation Gli2 cells. The 2 strongly repressed growth rather than peri‐tumor stroma...
To explore the clinical value of combining pyramidal tract mapping, microscopic-based neuronavigation, and intraoperative magnetic resonance imaging (iMRI) in surgical treatment epileptic foci involving sensorimotor cortex.We retrospectively analyzed 69 patients with focal epilepsy motor sensory cortex. The operations Group I (n=38) were performed under guidance conventional II (n=31) aided by neuronavigation iMRI technique. Chi square test was used to compare seizure outcome neurological...
Abstract To investigate the role of GLI1 on skin proliferation and neovascularization during expansion in mice. We constructed GLI1‐cre/R26‐Tdtomato GLI1‐cre/R26‐mtmg gene‐tagged mouse models. Using a two‐photon vivo imaging instrument to observe changes number distribution GLI1(+) cells process clarify spatial relationship between blood vessels process. In vitro assays were performed further validate effects SHH (sonic hedgehog) its downstream component cell viability. Finally, qRT‐PCR was...
<h3>Background</h3> Compared to normal cells or their corresponding tissues, CD200 is overexpressed in various cancers such as kidney cancer, head and neck colon cancer. The upregulation of on human cancer has an immunosuppressive effect immune within the tumor microenvironment, creating conditions that favor development, growth, spread. This indicates a potential therapeutic target prognostic factor for range malignant tumors. <h3>Methods</h3> To evaluate preclinical efficacy therapies...
Early detection of cancer via screening greatly increases the chances for successful treatment. In Taiwan, several examinations and tests are feely provided by government to particular populations who at increased risk cancer, including: (1) Mammography (45–69 years old; once every two years), (2) Pap smears (>30 old per year), (3) Immunochemical fecal Occult Blood test (iFOBT; 50–74 years; years). This study aims examine differences in rate between female dementia patients (n=4,452)...
Abstract Migraine is one of the most prevalent and disabling neurological disease. The current treatments are limited. Acupuncture a promising complementary replacement therapy, but further clinical evidence needed. Besides, influence acupuncture on migraine not an immediate effect, mechanism this effect clear yet. This study to provide for anti-migraine effects explore mechanism. Herein, randomized controlled trial (48 participants in total; 10 normal controls 38 migraineurs) was performed....