A5005965963- Atrial Fibrillation Management and Outcomes
- Healthcare Policy and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Global Health Care Issues
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease and Transplantation
- Emergency and Acute Care Studies
- Healthcare Systems and Reforms
- Cardiac electrophysiology and arrhythmias
- Acute Ischemic Stroke Management
- Liver Disease Diagnosis and Treatment
- Cystic Fibrosis Research Advances
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
- Palliative Care and End-of-Life Issues
- Pharmacology and Obesity Treatment
- Cardiac Arrest and Resuscitation
- Primary Care and Health Outcomes
- Mosquito-borne diseases and control
- Urinary Tract Infections Management
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Diabetes Treatment and Management
- Cardiac Structural Anomalies and Repair
Chang Gung Memorial Hospital
2018-2025
Chang Gung University
2019-2025
National Health Research Institutes
2019-2025
Linkou Chang Gung Memorial Hospital
2018-2025
Mianyang Central Hospital
2025
University of Electronic Science and Technology of China
2025
Chang Gung University of Science and Technology
2010-2024
Guangdong Ocean University
2024
Taoyuan Chang Gung Memorial Hospital
2023-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Abstract Background Taiwan established a system of universal National Health Insurance (NHI) in March, 1995. Today, the NHI covers more than 98% Taiwan's population and enrollees enjoy almost free access to healthcare with small co-payment by most clinics hospitals. Yet while this expansion coverage will inevitably have improved health care, however, it cannot be assumed that necessarily population. The aim study was determine whether introduction 1995 associated change deaths from causes...
<h3>Importance</h3> Glucagon-like peptide-1 (GLP-1) receptor agonist use is associated with reduced mortality and improved cardiovascular outcomes in the general population diabetes. Dipeptidyl peptidase-4 (DPP-4) inhibitors are commonly used antidiabetic agents for patients advanced-stage chronic kidney disease (CKD). The association of these 2 drug classes among diabetes CKD or end-stage (ESKD) not well understood. <h3>Objective</h3> To assess whether GLP-1 agonists a ESKD better compared...
Patients with liver cirrhosis face high infection risks due to immune dysfunction and hospital-related factors, increasing mortality rates when sepsis occurs. While various biomarkers predict outcomes in cirrhosis, few are accessible reliable. This study addresses the gap by evaluating prognostic potential of lactate-to-albumin ratio (LAR). We retrospectively analyzed data from patients who were admitted intensive care unit at Beth Israel Deaconess Medical Center between 2008 2022. LAR was...
Patients with primary Sjögren's syndrome (pSS) are at a higher risk of developing non-Hodgkin's lymphoma (NHL). However, little is known regard to the cancers other than NHL. The authors aimed in this study compare incidence cancer various sites among patients pSS general population Taiwan.The used National Health Insurance claims data establish nationwide cohort 7852 from 2000 2008 who did not have prior diagnosis pSS. Incidence and standardised ratios (SIRs) for were calculated.Among pSS,...
Abstract Background Bronchiectasis is a chronic infectious respiratory disease with diverse causes and ethnic or geographic differences. However, few large-scale studies of its etiology have been conducted in Asia. This study aimed to determine the clinical features bronchiectasis Taiwan. Methods longitudinal cohort investigated newly diagnosed non-cystic fibrosis patients from January 2002 December 2016. The clinical, functional microbiological data were retrieved Chang Gung Research...
Objective. To estimate the incidence and mortality of treated primary Sjögren’s syndrome (pSS) by sex age group in Taiwan. Methods. We used claims data Bureau National Health Insurance (NHI) Taiwan from 2005 to 2007 for analysis. According NHI, pSS is classified as one financially catastrophic illnesses patients with could be exempted copayment all medical costs. obtain a illness certificate (CIC) pSS, are required meet criteria American-European Consensus Group reviewed committee. Patients...
Aspirin increases the risk of gastrointestinal bleeding.To investigate lower bleeding (LGIB) in aspirin users.Low-dose (75-325 mg daily) users and controls matched by age, gender enrollment time a 1:5 ratio were selected from 1 million randomly sampled subjects National Health Insurance Research Database Taiwan. Cox proportional hazard regression models developed to evaluate predictors LGIB with adjustments for gender, comorbidities including coronary artery disease, ischaemic stroke,...
This study compared the risk of major bleeding between atrial fibrillation (AF) patients who took non-vitamin K antagonist oral anticoagulants (NOACs) and antiepileptic drugs (AEDs) concurrently those only NOACs.We performed a retrospective cohort using Taiwan National Health Insurance database included AF received NOAC prescriptions from 1 June 2012 to 31 December 2017. The risks person-quarters exposed 11 concurrent AEDs (carbamazepine, gabapentin, lamotrigine, levetiracetam,...
Aortic dissection (AD) is a life-threatening emergency. However, the heritability and association of family history with late outcomes are unclear. The purpose this study was to evaluate effect AD on incidence prognosis estimate environmental contribution in Taiwan. Both cross-sectional cohort studies were conducted using Taiwan National Health Insurance database. A registry parent–offspring relationship algorithm used reconstruct genealogy population for estimation. included 23,868 patients...
Abstract Purpose Multidrug-resistant (MDR) bacteria impose a considerable health-care burden and are associated with bronchiectasis exacerbation. This study investigated the clinical outcomes of adult patients following MDR bacterial infection. Methods From Chang Gung Research Database, we identified infection from 2008 to 2017. The control group comprised who did not have were propensity-score matched at 1:2 ratio. main in-hospital 3-year mortality. Results In total, 554 both identified....
Abstract Background and Aims Studies on the impact of syphilis cardiovascular system in large populations are limited. This study investigated effects outcomes. Methods Medical records from 2010 to 2015 were retrieved Taiwan National Health Insurance Research Database, linked Notifiable Infectious Diseases database Centers for Disease Control. Patients with identified, excluding those missing information, under 20 years age, or a history human immunodeficiency virus infection, acute...
Studies have shown an association between lower urinary tract symptoms (LUTS) and increased risk of dementia. Whether anticholinergic use contributes to the development dementia in patients with LUTS remains unknown, especially Asian populations. This study aims investigate LUTS.This included aged 50 years over newly diagnosed (January 2001 December 2005), divided into four groups according their cumulative defined daily doses (cDDDs) anticholinergics: < 28 cDDDs, 28-84 85-336 ≥337 cDDDs....
Background Dengue virus (DENV) infection may be associated with increased risks of major adverse cardiovascular effect (MACE), but a large-scale study evaluating the association between DENV and MACEs is still lacking. Methods findings All laboratory confirmed dengue cases in Taiwan during 2009 2015 were included by CDC notifiable database. The self-controlled case-series design was used to evaluate MACE (including acute myocardial infarction [AMI], heart failure stroke). "risk interval"...
Bronchiectasis is characterized by systemic inflammation and multiple comorbidities. This study aimed to investigate the clinical outcomes based on bronchiectasis etiology comorbidity index (BACI) score in patients hospitalized for severe exacerbations. We included non-cystic fibrosis exacerbations between January 2008 December 2016 from Chang Gung Research Database (CGRD) cohort. The main outcome was 1-year mortality rate after used Cox regression model assess risk factors of mortality. Of...
Background: Non-pharmaceutical interventions (NPIs) were widely used during the coronavirus disease 2019 (COVID-19) pandemic, however their impact on acute asthma exacerbations (AEs) is not well studied.Methods: We had retrospectively collected patients with AEs between and 2020 retrieved data from Chang Gung Research Database, including clinical manifestations, medications, pulmonary function, clinic emergency department visits hospitalizations.Results: A total of 39,108 adult enrolled,...
Background Ovarian cancer is among the most lethal gynecologic malignancies, with a high proportion of patients diagnosed at advanced stages, leading to poor survival outcomes. Axillary lymph node metastasis from ovarian extremely rare and mechanism still unclear. Methods A comprehensive set clinical oncology assessments were performed, including ultrasound, mammography, MRI, transvaginal tissue staining. To unravel carcinogenesis, next-generation sequencing (NGS) was performed. Results...