A5038285208- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Frailty in Older Adults
- Pharmaceutical Practices and Patient Outcomes
- Chronic Disease Management Strategies
- Bone health and osteoporosis research
- Blood Pressure and Hypertension Studies
- Dementia and Cognitive Impairment Research
- Bone health and treatments
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Health disparities and outcomes
- Hip and Femur Fractures
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Drug-Induced Adverse Reactions
- Pharmacovigilance and Adverse Drug Reactions
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Toxicity Studies
- Acute Myocardial Infarction Research
- Lymphoma Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Body Composition Measurement Techniques
- Nutritional Studies and Diet
National Taiwan University
2016-2025
National Taiwan University Hospital
2016-2025
Zero to Three
2020
Institute of Clinical Research
2017
National Yang Ming Chiao Tung University
2006-2015
Taipei Veterans General Hospital
2013-2015
Chang Gung University
2015
China Medical University Hospital
2014
China Medical University
2014
University of the Pacific
2011-2014
<h3>Background:</h3> Polypharmacy, potentially inappropriate medications and anticholinergic burden (as assessed by the risk scale) are commonly used as quality indicators of pharmacotherapy in older adults. However, their role clinical practice is undefined. We sought to investigate longitudinal changes these effects on outcomes. <h3>Methods:</h3> Taiwan's Longitudinal Health Insurance Database retrieve quarterly information about drug use for people aged 65 years over a 10-year period....
Integrating primary prevention into care pathways for older adults is a core strategy of healthy ageing, but evidence remains limited. We aimed to determine whether incorporating multidomain intervention health could improve standard value-based outcomes and quality life.For this Taiwan Integrated Geriatric Care (TIGER) study, pragmatic randomised controlled trial, we recruited community-dwelling outpatients aged 65 years or with at least three chronic medical conditions. excluded people...
Abstract Background Frailty often coexists with heart failure (HF), which significantly aggravates the clinical outcomes of older adults. However, studies investigating interplay between frailty and HF in adults are scarce. We aimed to assess prevalence using cumulative deficit approach evaluate impacts on health utilization, use HF‐related medications adverse (all‐cause mortality, all‐cause readmissions readmissions) among patients. Methods A total 38 843 newly admitted patients were...
ABSTRACT Background The vigour of our musculature wanes as the years advance, and prognosticating concomitant trajectories throughout course life assumes paramount importance for judicious timely interventions. In present study, we aimed to establish age‐ sex‐specific reference centiles multiple muscle health metrics reveal distributions these aging process in Asian population. Methods By using cross‐sectional pooled data community dwellers aged 20 or older eight cohorts from Taiwan, Japan...
Objective. The aim of this population-based study is to examine the adverse events (AE) associated with longitudinal systemic glucocorticoid (GC) use among an ethnic Chinese lupus erythematosus (SLE) cohort. Methods. Our subjects were patients newly diagnosed SLE aged 18 and older who received at least 1 prescription GC between 2001 2012 from Taiwan’s National Health Insurance Research Database (NHIRD). earliest date for each subject was defined as index date. For subject, we calculated...
Components of physical frailty cluster into subtypes, but it remains unknown how these might be associated with age-related functional declines and multimorbidities. This study aims to investigated associations subtypes multimorbidity in a 10 year longitudinal cohort survey.Complementary used group-based multitrajectory modelling verify whether discovered Taiwan are presented another aging cohort, then cognitive decline multimorbidity. Participants aged ≥50 years were recruited from the...
Our aim was to explore the patterns of intrinsic capacity (IC) impairments among community-dwelling older adults and associations these different with excessive polypharmacy, potentially inappropriate medications, adverse drug reactions in a nationwide population-based study. A cross-sectional study included from Taiwan Integrated Care for Older People (ICOPE) program 2020. The subjects comprised 38,308 aged 65 years who participated ICOPE Step 1 screening assessed six domains IC following...
This study aims to develop and validate an integrative intrinsic capacity (IC) scoring system, investigate its associations with a wide spectrum of biomarkers explore the predictive value IC score on 4-year mortality among community dwelling people aged 50 years older.We included 839 adults ≥50 from Social Environment Biomarkers Aging Study (SEBAS) randomly divided them into derivation validation cohorts system. The multivariate logistic regression model was used weight each subdomain...
This study aimed to explore the biological features and mortality risk of intrinsic capacity (IC) functional ability (FA). Based on data from 1839 participants I-Lan Longitudinal Aging Study, multivariable Cox proportional hazard models were used evaluate predictive IC (range 0â100) FA 10-year mortality. Of 2038 repeated measurements for within a 7-year observational period, logistic regression was compare with maintained, improved rapidly deteriorated IC. A 1-point increased value...
Abstract Aims Frailty substantially increased the risk of adverse clinical outcomes, which was also critical in diabetes management. This study aimed to investigate interrelationships between age onset, frailty, anti-diabetic medications and outcomes people with mellitus (DM). Methods A total 123,172 aged 40 years older who were newly diagnosed DM identified categorised into four frailty subgroups (robust, mild, moderate severe) based on multimorbidity index (mFI). Cox proportional hazards...
Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Given these considerations, the present study aims to elucidate roles of social in older adults anorexia aging and/or sarcopenia respect long-term mortality using nationally representative cohort study. Data were obtained from Taiwan Longitudinal Study on Aging (TLSA), sample size 3,762 participants...
Sarcopenia and intrinsic capacity (IC) declines pose significant challenges to healthy aging, particularly in the rapidly growing octogenarian population. This study aimed elucidate relationship between sarcopenia IC across multiple cohorts of community-dwelling older adults.
GLP-1 receptor agonists and SGLT2 inhibitors are increasingly being used in people with type 2 diabetes on the basis of findings from randomised clinical trials; however, little is known whether outcomes affected by frailty real-world settings. We aimed to compare effectiveness safety managing diabetes, a specific focus stratifying their status.
Existing operational definitions of frailty are personnel-costly and time-consuming, resulting in estimates with a small sample size that cannot be generalized to the population level. The objectives were develop multimorbidity index using Taiwan's claim database, understand its ability predict adverse event.This is retrospective cohort study. Subjects aged 65 100 years who have full National Health Insurance coverage 2005 included. We constructed cumulative deficit approach categorized...
<h3>PURPOSE</h3> No consensus has been reached regarding which anticholinergic scoring system works most effectively in clinical settings. The aim of this population-based cohort study was to examine the association between medication burden, as defined by different scales, and adverse outcomes among older adults. <h3>METHODS</h3> From Taiwan's Longitudinal Health Insurance Database, we retrieved data on monthly drug use measured Anticholinergic Risk Scale (ARS), Cognitive Burden (ACB), Drug...