Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). Recent studies animal models of indicate that the interaction between inhibitory receptor, programmed death (PD)-1, on lymphocytes its ligand (PD-L1) play a critical role T-cell exhaustion by inducing inactivation. High PD-1 expression levels peripheral T-lymphocytes possibility improving function blocking PD-1-mediated signaling confirm importance this pathway...

This prospective cohort study investigated the impact of Helicobacter pylori infection on development various gastric malignancies.We prospectively followed up 1,225 dyspeptic Taiwanese who had nonulcer dyspepsia, ulcers, or duodenal ulcers at enrollment. Among them, 618 (50.4%) H. and 607 (49.6%) did not. Patients underwent endoscopy enrollment 1- to 3-yr intervals thereafter.During a mean follow-up 6.3 yr, adenocarcinoma developed in 7 pylori-infected patients, but none uninfected patients...

Abstract Infection by cagA-positive Helicobacter pylori (H. pylori) is strongly associated with gastric carcinomas and mucosa–associated lymphoid tissue (MALT) lymphomas. H. translocates the bacterial protein CagA into epithelial cells, translocated deregulates intracellular signaling pathways thereby initiates pathogenesis. This in turn raised possibility that development of MALT lymphomas during persistent infection direct interaction B lymphocytes. In this work, we showed can be directly...

Objective. The aim of this population-based study is to examine the adverse events (AE) associated with longitudinal systemic glucocorticoid (GC) use among an ethnic Chinese lupus erythematosus (SLE) cohort. Methods. Our subjects were patients newly diagnosed SLE aged 18 and older who received at least 1 prescription GC between 2001 2012 from Taiwan’s National Health Insurance Research Database (NHIRD). earliest date for each subject was defined as index date. For subject, we calculated...

Abstract TNF-related apoptosis-inducing ligand (TRAIL, also called Apo2L), a novel member of TNF superfamily, induces apoptosis in transformed cell lines diverse origin. TRAIL is expressed most the cells, and expression up-regulated activated T cells. Four receptors for have been identified, there complex interplay between vivo. The actual biological function TRAIL/TRAIL receptor still not clear. Growing evidence has demonstrated that members superfamily transduce signals after engagement...

Abstract Hepatitis C virus (HCV) is a major human pathogen causing chronic liver disease, which leads to cirrhosis of and hepatocellular carcinoma. The HCV core protein, viral nucleocapsid, has been shown affect various intracellular events, including cell proliferation apoptosis. However, the precise mechanisms effects are not fully understood. In this study, we show that protein sensitizes carcinoma line, Huh7, conferred sensitivity TRAIL-, but Fas ligand-mediated Huh7 cells resistant...

Background:General obesity and its progression are major predictors of future hypertension. It has not been established whether abdominal contributes to the development

B7-H1 [programmed death-ligand-1 (PD-L1)] is a B7-family member that binds to programmed death-1 (PD-1). Recently, deficiency of PD-L1 has been demonstrated result in accelerated gastric epithelial cell damage gastritis, and suggested play critical role regulating T homeostasis. Here, we aimed gain more insight into expression, regulation function during Helicobacter pylori infection. expression human cells was analysed using Western blotting, quantitative polymerase chain reaction...

We recently developed a mouse model of hepatitis B virus (HBV) persistence, in which single i.v. hydrodynamic injection HBV DNA to C57BL/6 mice allows replication and induces partial immune response, so that about 20–30% the carry for more than 6 months. The was used identify viral antigen crucial persistence. knocked out individual genes by introducing premature termination codon core, HBeAg, HBx, polymerase ORFs. specific-gene-deficient mutants were hydrodynamically injected into profiles...

Persistent hepatitis B viral (HBV) infection results in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC). An efficient control of virus infections requires the coordinated actions both innate adaptive immune responses. In order to define role immunity effectors against HBV, clearance was studied a panel immunodeficient mouse strains by hydrodynamic injection approach. Our demonstrate that HBV is not changed IFN-α/β receptor (IFNAR), RIG-I, MDA5, MYD88, NLRP3, ASC, IL-1R...

Biologic activities of functional mediators activate downstream transducers regulating inflammation and carcinogenesis. Correlation among (IL-6, IL-27, TNF-α, VEGF) with STAT proteins at diverse clinical-pathologic stages hepatocellular carcinoma (HCC) remains limited. Serum assayed from 147 untreated HCC cases (HCC-total group) included 70 HBV-infected (HCC-HBV group), 64 HCV-infected (HCC-HCV 13 without HBV-/HCV-infection (HCC-NBNC group). Another 156 non-HCC individuals comprised 54...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell apoptosis by transducing signals after interacting with its receptor (TRAIL-R). Although the actual biological role of TRAIL remains to be elucidated, recent accumulating evidence implies that regulates immune responses and homeostasis via an apoptosis-independent pathway, suggesting a novel immune-regulatory in autoimmune diseases. The purpose this study is address molecular mechanism regulating T activation...

Background: Although the eradication of Helicobacter pylori infection benefits patients with gastric or duodenal ulcers, value eradicating in functional dyspepsia (FD) remains controversial. Aims: To determine whether H. can prevent subsequent development ulcers relieve symptoms patients. Methods: In a double‐blind, placebo‐controlled trial, 161 infected who had were randomly assigned to 7 days treatment lansoprazole‐based triple therapy placebo and then followed for 1 year. The main outcome...

ABSTRACT Helicobacter pylori infection is associated with an inflammatory response in the gastric mucosa, leading to chronic gastritis, peptic ulcers, and cancer. There increased T-cell infiltration at site of H. . CCR6, a specific β-chemokine receptor for CCL20 (MIP-3α/LARC/exodus), has recently been reported mediate lymphocyte homeostasis immune responses mucosal tissue, it may play role chemokine-mediated trafficking during inflammation. In this study, we investigated CCR6 its ligand,...

Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Recent evidence indicates that in addition to triggering apoptosis, the TNF-related apoptosis-inducing (TRAIL) induces differentiation. To understand TRAIL-mediated signal transduction mechanism osteoclastogenesis, we demonstrated TRAIL differentiation via a Tumor receptor-associated 6 (TRAF-6)-dependent signaling pathway....

Toll-like receptor (TLR)3 gene variants may correlate with clinical significance of chronic viral infections including HBV. We aimed to investigate the expression TLR3 in peripheral blood mononuclear cells (PBMCs) and liver hepatitis B (CHB) patients its response pegylated interferon or nucleoside analogue therapy.We consecutively enrolled 127 CHB 64 surface antigen-negative, anti-HCV-negative healthy individuals as controls. compared expressions on fresh PBMCs from controls, before during...

We previously reported that CagA can be translocated into B cells in Helicobacter pylori (HP) coculture media, and the translocation appears biologically significant as activation of relevant cellular pathways was noticed. In this study, we further explore if detected malignant HP-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Expression evaluated by immunohistochemistry. expression confirmed western blot analysis. The association between tumor response to HP eradication...