A5028158287- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Perovskite Materials and Applications
- Conducting polymers and applications
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Quantum Dots Synthesis And Properties
- Chalcogenide Semiconductor Thin Films
- Eosinophilic Esophagitis
- RNA Research and Splicing
- Evacuation and Crowd Dynamics
- Gut microbiota and health
- Cancer Cells and Metastasis
- earthquake and tectonic studies
- Gastrointestinal motility and disorders
- Remote Sensing and Land Use
- Hedgehog Signaling Pathway Studies
- Transportation Planning and Optimization
- RNA regulation and disease
- Structural Health Monitoring Techniques
- Ferroptosis and cancer prognosis
Zhengzhou University
2021-2025
Henan Academy of Sciences
2024-2025
Yunnan University
2006-2025
Institute of Biophysics
2013-2023
Chinese Academy of Sciences
2013-2023
North China Electric Power University
2020-2023
Tianjin University of Traditional Chinese Medicine
2022-2023
Fordham University
2022
Czech Academy of Sciences, Institute of Biophysics
2021
ORCID
2021
Abstract Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity hepatocellular carcinoma (HCC). However, biology hepatic CSCs remains largely undefined. Through analysis transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM , which is highly expressed in liver HCC tumours. LncBRM required for self-renewal maintenance tumour initiation. In CSCs, associates with BRM initiate BRG1/BRM switch BRG1-embedded BAF complex...
Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC) contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant expression long noncoding RNAs (lncRNA) has been associated with these processes but cellular mechanisms are obscure. In this study, we report HCC-associated (HCC-MSC) promote epithelial-mesenchymal transition (EMT) liver tumorigenesis. We identified a novel lncRNA termed lncRNA-MUF (MSC-upregulated factor) is highly...
The failure of perovskite solar cells (PSCs) under ultraviolet (UV) irradiation is a serious barrier commercial utilization. Here, two-stage degradation process TiO2-based PSCs discovered continuous UV in an inert atmosphere. In the first decay stage, oxygen vacancy-Ti3+ (Ti3+-VO) transform into active Ti4+-VO trap states excitation and cause photocarrier loss. Furthermore, can convert back Ti3+-VO through oxidizing I−, which result accumulation I3−. Sequentially, rapid decomposition...
Abstract Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression and drug resistance. Metabolic reprogramming is a cancer hallmark plays vital roles in liver tumorigenesis. However, the role of metabolic TICs remains poorly explored. Here, we identify mitochondria-encoded circular RNA, termed mcPGK1 (mitochondrial circRNA for translocating phosphoglycerate kinase 1), which highly expressed TICs. knockdown impairs TIC self-renewal, whereas its...
Group 3 innate lymphoid cells (ILC3) are an important regulator for immunity, inflammation and tissue homeostasis in the intestine, but how ILC3 activation is regulated remains elusive. Here we identify a new circular RNA (circRNA) circKcnt2 that induced ILC3s during intestinal inflammation. Deletion of causes gut severe colitis mice. Mechanistically, circKcnt2, as nuclear circRNA, recruits nucleosome remodeling deacetylase (NuRD) complex onto Batf promoter to inhibit expression; this turn...
Pyroptosis mediated by gasdermin protein has shown great potential in cancer immunotherapies. However, the low expression of proteins and systemic toxicity nonspecific pyroptosis limit its clinical application. Here, we designed a synthetic biology strategy to construct tumor-specific pyroptosis-inducing nanoplatform M-CNP/Mn@pPHS, which plasmid (pPHS) was loaded onto manganese (Mn)-doped calcium carbonate nanoparticle wrapped tumor-derived cell membrane. M-CNP/Mn@pPHS showed an efficient...
The nondestructive modification of the PEIE-2D MOF interfacial modified layer improves efficiency and stability perovskite solar cells.
Abstract Colorectal cancer (CRC) is one of the most common tumors around world. Circular RNA widely involved in tumor progression via unclear mechanisms. Here, circREEP3 found to be upregulated CRC tissues. upregulation predicts poor patient survival. knockout suppresses tumorigenesis and metastasis, impairs stem cell‐like phenotype. Mechanistically, recruits chromatin remodeling protein CHD7 FKBP10 promoter activates its transcription. Moreover, restricts RIG‐1‐dependent antitumor immunity....
Abstract Innate lymphoid cells (ILCs) exert important roles in host defense, tissue repair and inflammatory diseases. However, how ILC lineage specification is regulated remains largely elusive. Here we identify that circular RNA circTmem241 highly expressed group III innate (ILC3s) their progenitor cells. CircTmem241 deficiency impairs ILC3 commitment attenuates anti-bacterial immunity. Mechanistically, interacts with Nono protein to recruit histone methyltransferase Ash1l onto Elk3...
On January 1, 2024, a Mw7.6 earthquake occurred on the Noto Peninsula in Japan, with focal depth of 9.6 kilometers. To validate effectiveness using finite fault hybrid slip model to simulate strong ground motion events, this study utilized records from KiK-net station network National Research Institute for Earth Science and Disaster Resilience (NIED) Japan. Initially, 29 fundamental stations were selected, 13 these chosen further method. Constrained by geometric parameters initial...
Abstract Planar perovskite solar cells (PSCs) show huge promise as an efficient photovoltaic technology, where the inefficient carrier transport at hetero‐interface largely limits their performance advancement. Herein, bifacial surface potential regulation is realized in a monolithic film through interface doping, leading to optimized dual‐interfacial energy level alignment. In n‐i‐p planar device, up‐shift of Fermi on bottom first achieved bottom‐up diffusion Li + . Then, vitamin D2...