A5041359252- Neurobiology and Insect Physiology Research
- Cancer Cells and Metastasis
- Circadian rhythm and melatonin
- FOXO transcription factor regulation
- RNA regulation and disease
- Bioinformatics and Genomic Networks
- Neurological Disorders and Treatments
- Recycling and Waste Management Techniques
- Insect and Arachnid Ecology and Behavior
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Cerebrovascular and genetic disorders
- Insect symbiosis and bacterial influences
- RNA modifications and cancer
- Microplastics and Plastic Pollution
- Insect and Pesticide Research
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Insect Resistance and Genetics
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Invertebrate Immune Response Mechanisms
- Digestive system and related health
Zhengzhou University
2021-2025
Guizhou University
2024
Hubei Academy of Environmental Sciences
2023
China Agricultural University
2016-2021
Abstract Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression and drug resistance. Metabolic reprogramming is a cancer hallmark plays vital roles in liver tumorigenesis. However, the role of metabolic TICs remains poorly explored. Here, we identify mitochondria-encoded circular RNA, termed mcPGK1 (mitochondrial circRNA for translocating phosphoglycerate kinase 1), which highly expressed TICs. knockdown impairs TIC self-renewal, whereas its...
Abstract Breast cancer is the most common and leading cause of cancer-related deaths in women. Increasing molecular targets have been discovered for breast prognosis therapy. However, there still an urgent need to identify new biomarkers. Therefore, we evaluated biomarkers that may aid diagnosis treatment cancer. We searched three mRNA microarray datasets (GSE134359, GSE31448 GSE42568) identified differentially expressed genes (DEGs) by comparing tumor non-tumor tissues using GEO2R....
ABSTRACT Digestive system tumor, including esophageal gastric intestinal liver pancreatic and cholangiocarcinoma, are the most common tumors worldwide serve as a major cause of tumor‐related death. Cancer stem cells (CSCs) small group in that harbor self‐renewal, differentiation abilities, playing crucial role tumor initiation, progression, metastasis, supposed to be fundamental recurrence after conventional treatment. A comprehensive understanding targeting CSCs is key overcoming tumors. In...
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths across world. Due to lack reliable markers for early HCC detection, most patients are diagnosed in middle/late stages. Liver cancer stem cells (CSCs), which drivers liver tumorigenesis, usually emerge stage and also termed as tumor initiation (TIC). CSCs contribute initiation, propagation, metastasis play a key role therapy. Taking advantage online-available data sets, bioinformatic analyses, experimental...
Starvation caused by adverse feeding stresses or food shortages has been reported to result in sleep loss animals. However, how the starvation signal interacts with central nervous system is still unknown. Here, adipokinetic hormone (AKH)—Fork head Box-O (FOXO) pathway shown respond energy change and adjust of Drosophila through remodeling s-LNv (small ventral lateral neurons) dorsal projections. Our results show that prevents flies from going after first light-dark transition. The LNvs are...
Growing evidences indicate that RNA-binding proteins (RBPs) play critical roles in regulating the RNA splicing, polyadenylation, stability, localization, translation, and turnover. Abnormal expression of RBPs can promote tumorigenesis. Here, we performed a CRISPR screen using an RBP pooled knockout library identified 27 potential with role supporting colorectal cancer (CRC) survival. We found deletion/depletion INTS3 triggered apoptosis CRC. The
Peroxidases (POXs) make up a large superfamily of enzymes that act in wide range biological mechanisms, including maintaining appropriate redox balances within cells, among other actions. In this study, we cloned sequence encodes POX protein, SaPOX, from wheat aphids, Sitobion avenae. Amino acid alignment showed the SaPOX was conserved with POXs insect species. mRNA accumulations were present all nymphal and adult stages, at higher levels during first second instar, lower later stages life...
Background: Vascular dementia (VaD) is a prevalent neurodegenerative disease characterized by cognitive impairment due to cerebrovascular factors, affecting significant portion of the aging population and highlighting critical need understand specific targets mechanisms for effective prevention treatment strategies. We aimed identify pathways crucial genes involved in progression VaD through bioinformatics analysis subsequently validate these findings. Methods: conducted differential...