A5100378923- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Cardiac Imaging and Diagnostics
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Venous Thromboembolism Diagnosis and Management
- RNA Research and Splicing
- Congenital Heart Disease Studies
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Systemic Sclerosis and Related Diseases
- Atrial Fibrillation Management and Outcomes
- Lung Cancer Treatments and Mutations
- Microtubule and mitosis dynamics
- Immunotherapy and Immune Responses
- Antiplatelet Therapy and Cardiovascular Diseases
- Multiple and Secondary Primary Cancers
- Cardiac Structural Anomalies and Repair
- Erythropoietin and Anemia Treatment
Nanjing Drum Tower Hospital
2024-2025
Nanjing University of Chinese Medicine
2024-2025
Zhejiang University
2024-2025
Northwestern University
2018-2025
John H. Stroger, Jr. Hospital of Cook County
2021-2025
Second Affiliated Hospital of Nanjing Medical University
2024
Beijing University of Posts and Telecommunications
2024
Huanggang Central Hospital
2021-2024
Yangtze University
2022-2024
University of Iowa
2024
Abstract Platinum (Pt)‐based chemotherapy is the main treatment for ovarian cancer (OC); however, most patients develop Pt resistance (Pt‐R). This work shows that Pt‐R OC cells increase intracellular cholesterol through uptake via HDL receptor, scavenger receptor type B‐1 (SR‐B1). SR‐B1 blockade using synthetic cholesterol‐poor HDL‐like nanoparticles (HDL NPs) diminished leading to cell death and inhibition of tumor growth. Reduced accumulation in induces lipid oxidative stress reduction...
Abstract MicroRNAs (miRNAs) play fundamental roles in many developmental and physiological processes eukaryotes. MiRNAs plants generally regulate their targets via either mRNA cleavage or translation repression; however, which approach plays a major role whether these two function modes can shift remains elusive. Here, we identify miRNA, miR408-5p that regulates AUXIN/INDOLE ACETIC ACID 30 ( IAA30 ), critical repressor the auxin pathway switching action rice. We find usually inhibits protein...
Abstract Background. The EACH study assessed the efficacy of oxaliplatin, 5-fluorouracil, and leucovorin (the FOLFOX4 regimen) compared with doxorubicin alone in terms overall survival (OS), progression-free (PFS), safety patients advanced hepatocellular carcinoma (HCC). We present results this Chinese patients. Methods. In a multicenter, open-label, randomized, phase III (00471965), 371 (279 from People's Republic China) were randomized 1:1 to receive either or until disease progression,...
Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew and drive tumorigenicity could identify new treatments. Through comparative chromatin-state gene expression analyses in ovarian CSCs versus non-CSCs, we identified FOXK2 as a highly expressed stemness-specific transcription factor cancer. Its genetic depletion diminished stemness features reduced tumor initiation capacity. Our mechanistic studies highlight that directly regulated IRE1α (encoded by ERN1)...
Abstract Background Cancer‐associated cachexia (CAC) is a complex syndrome of progressive muscle wasting and adipose loss with metabolic dysfunction, severely increasing the morbidity mortality risk in cancer patients. However, there are limited studies focused on underlying mechanisms progression CAC due to complexity this lack preclinical models that mimics its stagewise progression. Methods We characterized initiation transgenic female mice ovarian tumours. measured proposed biomarkers...
Branched-chain amino acids (BCAAs), as essential acids, engage in various physiological processes, such protein synthesis, energy supply, and cellular signaling. The liver is a crucial site for BCAA metabolism, linking the changes homeostasis with pathogenesis of variety diseases their complications. Peripheral circulating levels show complex trends different diseases. This review delineates alterations BCAAs conditions including non-alcoholic fatty disease, hepatocellular carcinoma,...
ABSTRACT Coronary artery disease (CAD), the most common panvascular disease, can progress to chronic total occlusion (CTO). Drug‐eluting stent (DES) is one of standard CAD treatments, but in‐stent restenosis leading CTO challenging, with unclear optimal management. The efficacy drug‐coated balloons (DCB) for treating DES‐related (IS‐CTO) undetermined. In this single‐center retrospective cohort study 198 patients IS‐CTO post‐DES, 3‐year outcomes DCB, DES, and plain old balloon angioplasty...
The omentum is the primary site of metastasis for ovarian cancer (OC). Interactions between cells and adipocytes drive an invasive pro-metastatic phenotype. Here we studied cell-adipocyte crosstalk by using a direct co-culture model with immortalized human visceral pre-adipocytes (VNPAD) OC cells. We demonstrate increased proliferation, invasiveness, resistance to cisplatin co-cultured compared mono-cultured RNA-sequencing from vs. mono-culture revealed significant transcriptomic changes,...
Chromatin organization regulates transcription to influence cellular plasticity and cell fate. We explored whether chromatin nanoscale packing domains are involved in stemness response chemotherapy. Using an optical spectroscopic nanosensing technology we show that ovarian cancer-derived cancer stem cells (CSCs) display upregulation of compared non-CSCs. Cleavage under targets tagmentation (CUT&Tag) sequencing with antibodies for repressive H3K27me3 active H3K4me3 H3K27ac marks mapped...
Abstract Objectives To investigate the relapse rate of systemic lupus erythematosus (SLE) patients after glucocorticoids withdrawn, assess risk factors associated with disease and clarify outcome relapse. Methods Data SLE who discontinued during 2017–2022 were included. Cox regression model was used to estimate hazard ratio for different contributing Kaplan-Meier cumulative rate. For those relapsed, proportion regaining remission or LLDAS tracked, analyzed. Results Totally 217 included, whom...
ABSTRACT Digestive system tumor, including esophageal gastric intestinal liver pancreatic and cholangiocarcinoma, are the most common tumors worldwide serve as a major cause of tumor‐related death. Cancer stem cells (CSCs) small group in that harbor self‐renewal, differentiation abilities, playing crucial role tumor initiation, progression, metastasis, supposed to be fundamental recurrence after conventional treatment. A comprehensive understanding targeting CSCs is key overcoming tumors. In...
Thermal ablation is safe and effective for the treatment of hepatocellular carcinoma. However, it remains problematic with respect to liver metastases. Here, we aimed evaluate efficacy safety thermal in patients metastases.Eighty-nine 132 metastases measuring 0.8-5.0 cm were treated microwave (MWA) or radiofrequency (RFA). The primary lesions colorectal cancer 38 cases others 51, respectively. Local tumor control, complications, long-term survival analyzed.Complete was achieved 117 (88.6%)...
Reports concerning changes in hepatitis B virus (HBV) status and liver function hepatocellular carcinoma (HCC) during or after transcatheter arterial chemoembolization (TACE) have been rare the results inconsistent. The objective of this retrospective study was to evaluate these parameters a large cohort HBV-related HCC patients. One hundred seventy-two surface antigen positive patients with Child-Pugh grade A disease who underwent 228 sessions TACE were enrolled, related clinical laboratory...
Purpose: Elevated neutrophil to lymphocyte ratio (NLR) has been shown be a predictor of poor survival in certain malignancies. We hypothesised NLR might predict prognosis for patients with colorectal liver metastasis (CRLM) undergoing percutaneous radiofrequency ablation (RFA).Patients and methods: A cohort 92 consecutive metachronous CRLM treated RFA was retrospectively reviewed. Baseline clinico-pathological characteristics, recurrence, overall disease-free were compared according...