A5017965900- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Hepatitis B Virus Studies
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Advanced Battery Materials and Technologies
- Computational Drug Discovery Methods
- Advancements in Battery Materials
- Growth Hormone and Insulin-like Growth Factors
- Mesenchymal stem cell research
- Cholinesterase and Neurodegenerative Diseases
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- Ferroptosis and cancer prognosis
- Synthesis and Biological Evaluation
- Organ Transplantation Techniques and Outcomes
Zhejiang Ocean University
2022-2024
Zhejiang University
2018-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2018-2024
First Affiliated Hospital Zhejiang University
2019-2024
Hangzhou First People's Hospital
2023-2024
Westlake University
2024
Donghua University
2020-2024
National Clinical Research Center for Digestive Diseases
2024
Jilin Medical University
2022
Yanbian University
2022
Rational design of nanosystems that target tumor microenvironment have attracted widespread attention. However, it is still a great challenge to make multifunctional nanoplatform actively and selectively interacts with microenvironment, without causing toxicity surrounding normal tissues. Herein, the biodegradable Fe-doped MoOx (FMO) nanowires are designed as an anti-tumor nanoreagent possesses photothermal conversion ability (48.5%) magnetic properties for T1 weighted resonance imaging...
Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and need to be studied more systematically. We analyzed ubiquitinome HCC in this study have comprehensive insight into human metastasis.The protein levels 15 specimens with vascular invasion without were detected by ubiquitinome. Proteins significantly different HCCs used predict E3 ubiquitin ligases associated tumor metastasis. The topological network...
Branched-chain amino acids (BCAAs), as essential acids, engage in various physiological processes, such protein synthesis, energy supply, and cellular signaling. The liver is a crucial site for BCAA metabolism, linking the changes homeostasis with pathogenesis of variety diseases their complications. Peripheral circulating levels show complex trends different diseases. This review delineates alterations BCAAs conditions including non-alcoholic fatty disease, hepatocellular carcinoma,...
Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ALCF) is a complicated syndrome with extremely high short-term mortality. The artificial support system (ALSS) may improve the function for patients HBV-ACLF, but data on its outcomes are insufficient in China.We recruited HBV-ACLF this nationwide, multicenter, retrospective study. Patients were diagnosed by COSSH-ACLF criteria. Propensity score matching (PSM) analysis was used to generate compared pairs. (28/90 days) survival...
Drug-induced liver injury (DILI) is rare but clinically important due to a high rate of mortality. However, specific biomarkers for diagnosing and predicting the severity prognosis DILI are lacking. Here, we used targeted metabolomics identify quantify types bile acids that can predict DILI. A total 161 patients were enrolled in this prospective cohort study, as well 31 health controls. method was 24 acids. divided into mild, moderate, severe groups according disease severity. multivariate...
Abstract Lithium (Li) metal batteries are highly sought after for their exceptional energy density. However, practical implementation is impeded by the formation of dendrites and significant volume fluctuations in Li, which stem from uneven distribution Li‐ions uncontrolled deposition Li on current collector. Here, an amino‐functionalized reduced graphene oxide covered with polyacrylonitrile (PrGN) film electric field gradient structure prepared to deal such difficulties. This novel...
Acute-on-chronic liver failure (ACLF) is an acute decompensated syndrome based on chronic disease, while neutrophil recruitment the most critical early step. C-X-C motif chemokine ligand 1 (CXCL1), a cytokine that recruits neutrophils, was significantly upregulated in both ACLF mice and patients with ACLF. This present study aims to explore role of CXCL1 pathogenesis
The present study evaluated the potential combined effects of NAFLD and MetS on development osteoporosis. relationship between osteoporosis was assessed in 938 postmenopausal female participants. Moderate severe NAFLDs were as significant (SNAFLD). All subjects divided into 4 subgroups based status SNAFLD MetS. Relative excess risk interaction (RERI), attributable proportion (AP) interaction, synergy index (SI) used to investigate additive those two factors. NAFLD, SNAFLD, independent...
Increased oxidative stress levels play a key role in idiosyncratic drug-induced liver injury (DILI) pathogenesis. To investigated whether advanced oxidation protein products (AOPPs) and ischaemia-modified albumin (IMA) can be used to monitor DILI patients assess disease severity. We performed spectrophotometric assays AOPPs IMA 68 with severity grade 0-2 (non-severe group), 60 3-5 (severe 38 healthy controls. The results showed that baseline serum AOPPs/albumin IMA/albumin ratios were...
Tectorigenin has received attention due to its antiproliferation, anti‐inflammatory, and antioxidant activities. In this study, we investigated the effects of tectorigenin on lipopolysaccharide (LPS)/D‐galactosamine(D‐GalN)‐induced fulminant hepatic failure (FHF) in mice LPS‐stimulated macrophages (RAW 264.7 cells). Pretreatment with significantly reduced serum levels alanine aminotransferase (ALT) aspartate (AST), histological injury, apoptosis, mortality FHF mice, by suppressing production...
Abstract Background & Aims Non‐invasive assessment methods for liver fibrosis are urgently needed. The present study aimed to develop a novel diagnostic model staging in patients with chronic hepatitis B. Methods A cross‐sectional set of 417 B who underwent biopsy was enrolled and the METAVIR score adopted as reference staging. Results Among thyroid hormones, only level free tetraiodothyronine ( FT 4) decreased gradually P < .001). FibroStage, diagnosis that incorporates data on 4,...
Short peptide hydrogel was reported as a possible adjuvant for vaccines. In order to evaluate whether the Tetra-Peptide Hydrogel can be promising an H7N9 vaccine against highly pathogenic virus, we conducted this study.Tetra-Peptide Hydrogels (D and L conformations) were prepared by self-assembly system using Naproxen acid modified tetra of GFFY (Npx-GFFY). Mice received two immunizations with D-Tetra-Peptide vaccine, L-Tetra-Peptide or split vaccine. Fourteen days following second dose,...
Whether smoking and metabolic syndrome (MetS) can affect colorectal carcinoma (CRC) prognosis remains debatable. Therefore, the present study aimed to examine individual combined effects of MetS on patients with localized CRC, including stage I III disease. The relationship among status, MetS, CRC was assessed in 838 Chinese male patients. Cox proportional hazards regression analysis used evaluate adjusted for clinicopathological variables. Relative excess risk interaction (RERI),...
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a life-threatening disease with high mortality rate; the systemic inflammatory response plays vital role in progression. We aimed to determine if miRNA-mRNA co-regulatory network exists peripheral blood mononuclear cells (PBMCs) of HBV-ACLF patients, which might be important for prognosis.In patients meeting COSSH-ACLF criteria, age, cirrhosis and INR were independent risk factors 28-day 90-day poor prognosis. COSSH-ACLFs...
Purpose: Neutrophils and cytokines play a major role in the pathogenesis of acute-on-chronic liver failure (ACLF). We aimed to determine whether chemokine (CXC) ligand 1 (CXCL1), key marker neutrophil recruitment activation, could predict severity prognosis hepatitis B virus–related ACLF (HBV-ACLF). Methods: Hospitalized patients with HBV-ACLF were enrolled prospective study stratified as survivors (alive at 28 days) nonsurvivors (deceased days). Serum CXCL1 levels measured healthy controls,...
Shugoshin-like protein 2 (SGOL2) is a centromeric that ensures the correct and orderly process of mitosis by protecting maintaining centripetal adhesions during meiosis mitosis. Here, we examined potential role SGOL2 in cancers, especially hepatocellular carcinoma (HCC). One hundred ninety-nine normal adjacent tissues 202 HCC samples were collected this study. Human cells (SK-HEP-1 HEP-3B) employed present Immunohistochemistry, immunofluorescence, western blot, Co-Immunoprecipitation...
Abstract This study investigates the longitudinal dynamic changes in immune cells COVID-19 patients over an extended period after recovery, as well interplay between and antibodies. Leveraging single-cell mass spectrometry, we selected six four healthy controls, dissecting evolving landscape within months post-viral RNA clearance, alongside levels of anti-spike protein The T cell immunophenotype ascertained via spectrometry underwent validation through flow cytometry 37 samples. Our findings...