A5102866282- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- ATP Synthase and ATPases Research
- Plant Virus Research Studies
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Circular RNAs in diseases
- Protein Degradation and Inhibitors
- CRISPR and Genetic Engineering
- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Physiological and biochemical adaptations
- Gene expression and cancer classification
- Photosynthetic Processes and Mechanisms
- Biotin and Related Studies
Second Affiliated Hospital of Zhejiang University
2024
Zhejiang University-University of Edinburgh Institute
2024
National Institute of Diabetes and Digestive and Kidney Diseases
2022-2024
National Institutes of Health
2020-2024
Protein Express (United States)
2021
Institute of Genetics and Developmental Biology
2011-2017
Chinese Academy of Sciences
2011-2017
Shanghai Ocean University
2017
Abstract Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. Here, we identified Drosophila factor Motif 1 Binding Protein (M1BP) in physical association with gypsy chromatin insulator core complex, including universal protein CP190. M1BP required for enhancer-blocking barrier activities of as well its proper nuclear localization. Genome-wide, specifically colocalizes CP190 at...
Abstract Background MicroRNAs (miRNAs) play important roles in regulating the expression of protein-coding genes by directing degradation and/or repression translation gene transcripts. Growing evidence shows that miRNAs are indispensable player organismal development with its regulatory role growth and differentiation cell lineages. However, miRNA-mediated regulation environmental adaptation organisms largely unknown. To examine this potential capability, we characterized microRNAomes from...
Abstract Motivation ChIP-seq detects protein–DNA interactions within chromatin, such as that of chromatin structural components and transcription machinery. profiles are often noisy variable across replicates, posing a challenge to the development effective algorithms accurately detect differential peaks. Methods have recently been designed for this purpose but sometimes yield conflicting results inconsistent with underlying biology. Most existing perform well on limited datasets. To improve...
Mitochondrial functions can be regulated by membrane contact sites with the endoplasmic reticulum (ER). These mitochondria–ER (MERCs) are functionally heterogeneous and maintained various tethers. Here, we found that REEP5, an ER tubule-shaping protein, interacts Mitofusins 1/2 to mediate mitochondrial distribution throughout cytosol a new transport mechanism, “hitchhiking” tubular on microtubules. REEP5 depletion led reduced tethering increased perinuclear localization of mitochondria....
Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive chromatin and block communication between enhancers promoters to regulate gene expression. In Drosophila, gypsy insulator complex consists three core proteins: CP190, Su(Hw), Mod(mdg4)67.2. These factors concentrate at nuclear foci termed bodies, changes in body localization have been observed mutants defective for function. Here, we identified NURF301/E(bx), a nucleosome remodeling factor, as novel...
ABSTRACT Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. Here, we identified Drosophila factor Motif 1 Binding Protein (M1BP) in physical association with gypsy chromatin insulator core complex, including universal protein CP190. M1BP required for enhancer-blocking barrier activities of as well its proper nuclear localization. Genome-wide, specifically colocalizes CP190 at...