A5079337861- Sperm and Testicular Function
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Physiology in Livestock
- RNA modifications and cancer
- Selenium in Biological Systems
- TGF-β signaling in diseases
- Phytoestrogen effects and research
- Fatty Acid Research and Health
- Genetic Mapping and Diversity in Plants and Animals
- Mitochondrial Function and Pathology
- Ruminant Nutrition and Digestive Physiology
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- Molecular Biology Techniques and Applications
- Liver Disease Diagnosis and Treatment
- GABA and Rice Research
- Animal Genetics and Reproduction
- Growth Hormone and Insulin-like Growth Factors
- Genomics and Phylogenetic Studies
- Plant Gene Expression Analysis
- Lipid metabolism and biosynthesis
- Sexual Differentiation and Disorders
Lanzhou University
2017-2025
Ministry of Agriculture and Rural Affairs
2019-2025
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2019-2024
Harbin Medical University
2021-2024
Institute of Grassland Research
2019-2024
Heilongjiang Bayi Agricultural University
2021-2024
Chinese Academy of Agricultural Sciences
2023-2024
Tobacco Research Institute
2023-2024
Fanjingshan National Nature Reserve
2023-2024
Sun Yat-sen University
2021-2023
Ferroptosis is a nonapoptotic form of regulated cell death that has been reported to play central role in cardiac ischemia‒reperfusion (I/R) injury. N-acetyltransferase 10 (NAT10) contributes cardiomyocyte apoptosis by functioning as an RNA ac4c acetyltransferase, but its ferroptosis during I/R injury not determined. This study aimed elucidate the NAT10 well underlying mechanism. The mRNA and protein levels were increased mouse hearts after cardiomyocytes exposed hypoxia/reoxygenation. P53...
Cardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1-catalyzed RNA N7-methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate the role of Mettl1 mechanism underlying non-ischemic HF. It found that upregulated human failing hearts hypertrophic murine following transverse aortic constriction (TAC) Angiotensin II (Ang II) infusion. YY1 acts as...
Heritable rumen microbiota is an important modulator of ruminant growth performance. However, no information exists to date on host genetics-rumen interactions and their association with phenotype in sheep. To solve this, we curated analyzed whole-genome resequencing genotypes, 16S rumen-microbiota data, longitudinal body weight (BW) phenotypes from 1150 sheep.A variance component model indicated significant heritability microbial community diversity. Genome-wide studies (GWAS) using...
Low temperature causes rice yield losses of up to 30%–40%, therefore increasing its cold tolerance is a breeding target. Few genes in are reported confer at both the vegetative and reproductive stages. This study revealed rice-specific 24-nt miRNA, miR1868, whose accumulation was suppressed by stress. Knockdown MIR1868 increased seedling survival, pollen fertility, seed setting, grain under stress, whereas overexpression conferred opposite phenotype. reactive oxygen species (ROS) scavenging...
Cryptorchidism is one of the most common reproductive abnormalities in rams, which seriously harms capacity rams and causes significant economic losses to sheep industry. However, there are few studies elucidating its hereditary predisposition sheep. In present study, transcriptome proteome cryptic (CT) contralateral (CLT) testis from four unilaterally cryptorchid normal (NT) healthy were analyzed using RNA-seq TMT-based proteomics, respectively. A total 10,357, 10,175, 132 differentially...
Abstract Chinese wild rice ( Zizania latifolia ) is rich in phenolic compounds, particularly flavonoids. This study identified 203 basic helix‐loop‐helix (bHLHs) Z. and showed that ZlbHLH196 Zla16G011250 corresponds to the ZlRc gene , with its protein product localizing nucleus. Notably, pericarps of ‐overexpressing (OE) are brown, whereas those wild‐type (WT) nonpigmented. The total phenolic, flavonoid, proanthocyanidin contents, antioxidant activity, as well enzyme inhibitory effects ‐OE...
This study is aims to compare the anesthetic safety of propofol combined with etomidate for painless gastroscopy.Three hundred patients undergoing gastroscopy were randomly assigned P, PE1, and PE2 groups. Patients anesthetized (P group) or (volume ratio 1: 1, PE1 group; volume 2: group). The hemodynamics adverse reactions observed. sleep quality satisfaction nature dreams recorded.Compared pre-anesthesia, mean arterial pressure heart rate 3 groups significantly slower during examination at...
Hu sheep and Small-tailed Han are the most widely raised famous maternal breeds in China, which known for precocious puberty, perennial oestrus high fecundity (1–6 lambs each parity). Therefore, it is crucial to increase litter size of these two intensive industry. The objective this study was identify potential genetic markers linked with located at ten genes. This collected blood sample 537 420 first parity. average sizes were 2.21 1.93. DNA-pooling sequencing method used detecting single...
Background. Tumor immunotherapy and immunological checkpoint-related proteins are research hotspots. Intensity-modulated radiotherapy (IMRT) is the main treatment for nasopharyngeal carcinoma (NPC). Hence, evaluation of its effect very important. The aim this study was to assess relationship between concentrations soluble checkpoint proteins, plasma EBV-DNA, cytokines in NPC patients treated with IMRT. Methods. In study, samples 37 40 healthy controls were collected. Luminex MAGPIX used...
The deleted in azoospermia-like (DAZL) gene encoding an RNA binding protein is pivotal gametogenesis lots of species and also acts as a pre-meiosis marker. current study was conducted to detect expression profiles single nucleotide polymorphisms (SNPs) DAZL sheep using qPCR, DNA-pooled sequencing, improved multiplex ligase detection reaction (iMLDR®) restriction fragment length polymorphism (RFLP) methods. results confirmed that ovine showed the highest level at six-months age across five...
This study aimed to investigate the effect of Codonopsis pilosula polysaccharide (CPP) on motility, mitochondrial integrity, acrosome integrity rate, and antioxidant ability sheep sperm after preservation at 4°C.
The selection of testis size can improve the reproductive capacity livestock used for artificial insemination and has been considered as an important strategy accelerating breeding process. Although much work done to investigate mechanisms development in various species, there is little information available regard differences transcriptomic profiling sheep testes at different developmental stages. In this work, we aimed identify differentially expressed genes (DEGs) by RNA-Seq during growth...
Chaperonin-containing TCP1 subunit (CCT) 6A is an oncogenic 6th of the CCT family. Nevertheless, not much documented regarding its function in colorectal cancer (COAD). This investigation seeks to explore role CCT6A prognosis COAD.Sequencing data from Gene Expression Omnibus (GEO) and Cancer Genome Atlas database (TCGA) were employed analyze expression involvement various regulatory networks behind COAD. Oncomine Profiling Interactive Analysis (GEPIA) analyzed Levels survival rates, while...