A5100612672- Mosquito-borne diseases and control
- Genetic and phenotypic traits in livestock
- Osteoarthritis Treatment and Mechanisms
- Molecular Biology Techniques and Applications
- Insect Pest Control Strategies
- Insect Resistance and Genetics
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Photosynthetic Processes and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Genetic Mapping and Diversity in Plants and Animals
- Insect symbiosis and bacterial influences
- Lipid metabolism and biosynthesis
- Cerebrovascular and Carotid Artery Diseases
- Invertebrate Immune Response Mechanisms
- Intracranial Aneurysms: Treatment and Complications
- Prostate Cancer Treatment and Research
- Protease and Inhibitor Mechanisms
- Corneal surgery and disorders
- Neurological diseases and metabolism
- Muscle Physiology and Disorders
- Spaceflight effects on biology
Stanford University
2023-2025
Lanzhou University
2023-2024
Institute of Grassland Research
2024
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2024
Ministry of Agriculture and Rural Affairs
2024
Tongji Hospital
2018-2024
China University of Mining and Technology
2024
Changchun University of Technology
2024
Guangdong 999 Brain Hospital
2023-2024
Guangdong Ocean University
2022-2024
Osteoarthritis (OA) is a progressive degenerative joint disorder with cartilage degradation as the primary cause of pain and loss function. B-cell lymphoma-2-associated transcription factor 1 (BCLAF1) key regulator apoptosis serves signal transducer NFκB Hif-1α pathways, both which are involved in osteoarthritic degradation. However, whether BCLAF1 contributes to pathogenesis OA remains unclear. The present study aims elucidate role underlying mechanisms. We found that levels were increased...
Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers, etc., elastic modulus and strength PEEK can be changed meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced modify PEEK, which reinforced with different contents nanoparticles (from 1 wt% 9 wt%). Mechanical biological functions (both vitro vivo) then investigated. The highest...
Abstract Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in production are highly upregulated, but the mechanisms that control their expression remain poorly understood. Using integrated transcriptomic, lipidomic, molecular studies, here we report DAXX is a regulator of oncogenic lipogenesis. depletion attenuates, while its overexpression enhances, lipogenic gene expression, lipogenesis, tumor growth. Mechanistically, interacts with SREBP1...
The field of regeneration for functional cartilage has progressed tremendously. Conventional approaches regenerating the damaged tissue based on integrated manufacturing are limited by their inability to produce precise and customized biomimetic tissues. On other hand, 3D bioprinting is a promising technique with increased versatility because it can co-deliver cells biomaterials proper compositions spatial distributions. In present article, we review recent progress in complete printing...
Abstract Background Chilling injury of mung bean ( Vigna radiata (L.)) during the blooming and podding stages is a major agricultural threat in Northeast China. Uniconazole (UNZ) can alleviate water deficit stress soybean waterlogging bean. However, there has been no report on effect UNZ application growth transcriptomic profile under chilling stress. Results before at R1 stage alleviated decline yield. delayed decrease leaf chlorophyll content accelerated increase recovery period. Eighteen...
Geese play an important role in agricultural economics, with China producing the vast majority of goose meat consumed worldwide annually. The variations avian viruses and co-infections result substantial economic losses to industry China. To understand evolutionary characteristics viruses, a broad epidemiological investigation epizootic was carried out nine provinces during 2018-2021. Here, results indicated that, among 1970 clinical samples, 50.81% (1001/1970) were positive for astrovirus...
Purpose Patients with advanced prostate cancer (PCa) often develop castration-resistant PCa (CRPC) poor prognosis. Prognostic information obtained from multiparametric magnetic resonance imaging (mpMRI) and histopathology specimens can be effectively utilized through artificial intelligence (AI) techniques. The objective of this study is to construct an AI-based CRPC progress prediction model by integrating multimodal data. Methods materials Data 399 patients diagnosed at three medical...
Osteoarthritis (OA) is a whole-joint disease in which the role of infrapatellar fat pad (IFP) its pathogenesis unclear. Our study explored cellular heterogeneity IFP to understand OA and identify therapeutic targets. Single-cell single-nuclei RNA sequencing were used analyze 10 samples, comprising 5 from patients healthy controls. Analyses included differential gene expression, enrichment, pseudotime trajectory, communication, along with comparative studies visceral subcutaneous fats. Key...
• Phosphate is essential for many cellular processes including the light reactions of photosynthesis. Photosynthesis results in production triose phosphates that are transported across chloroplast envelope to cytosol counterexchange phosphate. Until recently, members plastid phosphate transport family, which mediate exchange phosphorylated compounds, were only proteins known into chloroplast. Here, we characterized a transporter, MtPHT2;1 Medicago truncatula. Transient expression an...
Joint loading is a recently developed modality, which can enhance bone formation and accelerate healing of fracture. Since mechanical stimulation alters expression matrix metalloproteinases (MMPs) in chondrocytes, question addressed herein was, does joint alter actions MMPs the articular cartilage? We hypothesized that activity are regulated load–intensity-dependent manner moderate load scan downregulates MMPs. To test this hypothesis, mouse elbow-loading model was employed. In cartilage an...
Aedes aegypti (L.) is a vector of chikungunya, dengue, yellow fever and Zika viruses. These viruses encounter variety induced defense responses from the innate immune system mosquito. We cloned defensin A Ae. using laboratory populations originating Key West Orlando, Florida. To characterize inducible peptides, we examined (DefA) C (DefC) expression through time course studies quantitative real-time PCR. observed that ingestion chikungunya virus (CHIKV) (ZIKV) infected blood triggered early...
The scope of lexical planning, which means how far ahead speakers plan lexically before they start producing an utterance, is important issue for research into speech production, but remains highly controversial. present investigated this using the semantic blocking effect, refers to widely observed effects that participants take longer say aloud names items in pictures when a block trials experiment depict belong same category than different categories. As effect often interpreted as...
Aedes aegypti (L.) is the primary vector of emergent mosquito-borne viruses, including chikungunya, dengue, yellow fever, and Zika viruses. To understand how these viruses interact with their mosquito vectors, an analysis innate immune system response was conducted. The a conserved evolutionary defense strategy dominant found in invertebrates vertebrates, as well plants. RNA-sequencing performed to compare target transcriptomes two Florida Ae. strains chikungunya virus infection. We analyzed...
Aedes aegypti (L.) is the primary vector of many emerging arboviruses. Insecticide resistance among mosquito populations a consequence application insecticides for control. We used RNA-sequencing to compare transcriptomes between permethrin resistant and susceptible strains Florida Ae. in response Zika virus infection. A total 2459 transcripts were expressed at significantly different levels aegypti. Gene ontology analysis placed these genes into seven categories biological processes. The...
Aedes aegypti (L.) is the primary vector of chikungunya, dengue, yellow fever, and Zika viruses. The leucine-rich repeats (LRR)-containing domain evolutionarily conserved in many proteins associated with innate immunity invertebrates vertebrates, as well plants. We focused on AaeLRIM1 AaeAPL1 gene expressions response to virus (ZIKV) chikungunya (CHIKV) infection using a time course study, developmental eggs, larvae, pupae, adults. RNA-seq analysis data provided 60 repeat related...
Fat deposition is an important economic trait that closely related to feed efficiency and carcass performance in livestock. In this study, the fat deposition-related traits of 1,293 Hu sheep were measured descriptive statistical analysis was conducted. The results showed coefficient variation all higher than 24%. addition, single nucleotide polymorphisms expression characteristics TRAPPC9 (encoding trafficking protein particle complex subunit 9) BAIAP2 brain-specific Angiogenesis inhibitor...