A5100428966- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
- Plant and animal studies
- Forensic and Genetic Research
- Genetic Mapping and Diversity in Plants and Animals
- Plant Ecology and Taxonomy Studies
- Advanced Glycation End Products research
- Genetics, Aging, and Longevity in Model Organisms
- Remote Sensing and Land Use
- Plant Taxonomy and Phylogenetics
- RNA modifications and cancer
- Food Drying and Modeling
- Cancer therapeutics and mechanisms
- Advances in Cucurbitaceae Research
- Postharvest Quality and Shelf Life Management
- Barrier Structure and Function Studies
- Cholesterol and Lipid Metabolism
- Phytochemistry Medicinal Plant Applications
Ministry of Education of the People's Republic of China
2021-2025
Northwest University
2021-2025
Center for Life Sciences
2025
Tsinghua University
2025
Peking University
2025
Southern Medical University
2024
Gansu Agricultural University
2022-2024
University of Illinois Urbana-Champaign
2021-2023
Jinan Maternity And Care Hospital
2023
Inner Mongolia Agricultural University
2022
Cell migration is involved in several pathological processes such as tumor invasion, neoangiogenesis and metastasis. Microtubules are needed directional migration. To investigate the effects of microtubule-binding agents (paclitaxel, vinblastine, colchicine, podophyllotoxin), benzophenanthridine alkaloids (sanguinarine, chelerythrine, chelidonine) other anti-tumor drugs (homoharringtonine, doxorubicin) on cell migration, we performed vitro wound healing assay. The interactions between...
Osteoporosis is an important clinical problem, affecting more than 50% of people over age 50 yr. Estrogen signaling critical for maintaining proper bone density, and the identification endogenous selective estrogen receptor (ER) modulator, 27-hydroxycholesterol (27HC), suggests a mechanism by which nutritional/metabolic status can influence biology. With its levels directly correlated with cholesterol, new possibility emerges wherein 27HC links cholesterol to homeostasis. In these studies,...
Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich purine alkaloids, markedly caffeine, extensively used Brazilian beverage industry for preparation soft drinks and as additives energy drinks. Methods: To investigate putative anti-aging antioxidant guarana, we model organism Caenorhabditis elegans. Chemical analyses were performed using...
Late embryogenesis abundant (LEA) proteins are a class of associated with osmotic regulation and plant tolerance to abiotic stress. However, studies on the LEA gene family in alpine cold-tolerant herb still limited, phylogenetic evolution biological functions its members remain unclear. In this study, we conducted genome-wide identification, evolution, stress response analyses genes Notopterygium species, medicinal herbs Qinghai-Tibet Plateau adjacent regions. The identification analysis...
RAS mutations enhance macroautophagy/autophagy in tumor cells, crucial for their growth and survival, making autophagy a promising therapeutic target RAS-mutant cancers. However, the distinction between RAS-induced physiological is not well understood. We recently identified unique form of autophagy, non-canonical via ATG8ylation (RINCAA), which differs from starvation-induced autophagy. RINCAA regulated by different sets autophagic factors forms structures distinct double-membrane...
Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions cucurbitacin B, E and I with cytoskeletal proteins such as microtubule actin filaments. The effects on microtubules filaments were studied living cells (Hela U2OS) vitro using GFP markers, immunofluorescence staining tubulin polymerization assay. Cucurbitacin apparently affected structures inhibited IC 50 value 566.91 ± 113.5 µM. did not affect...
Abstract Hybridization and introgression are believed to play important roles in plant evolution. However, few empirical studies have been designed clarify the ways which these processes complicate taxonomic delimitation. Recent phylogenetic based on a number of different DNA fragments indicated that Picea brachytyla eastern Qinghai‐Tibet Plateau is polyphyletic, finding contrasts with traditional taxonomy morphological traits. We aimed test this conflict using transcriptomic data from 26...
Alkaloids, the largest group among nitrogen-containing secondary metabolites of plants, usually interact with several molecular targets. In this study, we provide evidence that six cytotoxic alkaloids (sanguinarine, chelerythrine, chelidonine, noscapine, protopine, homoharringtonine), which are known to affect neuroreceptors, protein biosynthesis and nucleic acids, also cellular cytoskeleton, such as microtubules actin filaments, well. Sanguinarine, chelerythrine chelidonine depolymerized...
The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded the herbal medicine of Amazon region. Different preparations bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. current study aims provide first step towards a science-based evidence beneficial effects C. promotion longevity modulation age-related markers. For...
The role of reticulation in the rapid diversification organisms is attracting greater attention evolutionary biology. Evidence genetic exchange between diverging taxa reported frequently, although most studies fail to show how hybridization and introgression contribute adaptation differentiation introgressed taxa. Here, we report a population genomics approach test evolution Picea likiangensis species complex, which comprises four occurring biodiversity hotspot Hengduan–Himalayan mountains....
Oscillations of periods with low and high temperatures during the Quaternary in northern hemisphere have influenced genetic composition birds Palearctic. During last glaciation, ending about 12,000 years ago, a wide area Palearctic was under lasting ice and, consequently, breeding sites for most bird species were not available. At same time, diversity habitats accessible subtropical tropical zones providing grounds refugia birds. As result long-term climatic oscillations, migration systems...
As an important appearance trait, the rind color of watermelon fruit affects commodity value and further determines consumption choices. In this study, a comparative transcriptome analysis was conducted to elucidate genes pathways involved in formation yellow using inbred line WT4 green WM102. A total 2,362 differentially expressed (DEGs) between WM102 at three different stages (0, 7, 14 DAP) were identified 9,770 DEGs obtained by comparing expression level 7 DAP with former WT4. The...
Endopleura uchi (Huber) Cuatrec (Humiriaceae), known as uxi or uxi-amarelo in Brazil, is an endemic tree of the Amazon forest. In traditional medicine, its stem bark used to treat a variety health disorders, including cancer, diabetes, arthritis, uterine inflammation, and gynecological infections. According HPLC analysis, main constituent extract polyphenol bergenin. current study, we demonstrate by vitro vivo experiments antioxidant potential water from E. uchi. When tested model organism...
Male-specifically inherited Y-STRs, harboring the features of haploidy and lack crossing over, have gained considerable attention in population genetics forensic investigations. Goldeneye® Y-PLUS kit was a recently developed amplification system focused on genetic diversity 36 Y-chromosomal short tandem repeats (Y-STRs) East Asians. However, no data corresponding were reported China. Here, Y-STRs first genotyped 400 unrelated healthy Tai-Kadai-speaking Bouyei male individuals. A total 371...
Abstract Alfalfa (Medicago sativa L.) is a forage legume of world-wide importance used in agriculture. The genetic relationship and distance among cultivars great interest for breeding programs. Random amplified polymorphic DNA (RAPD) was the current study to evaluate variability 7 alfalfa Northwest China. A total 132 discernible loci were obtained all populations using 10 primers, 88.64% these polymorphic, which indicated that high diversity existed from Analysis molecular variation (AMOVA)...