A5101673741- Asymmetric Hydrogenation and Catalysis
- Cyclopropane Reaction Mechanisms
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Catalytic C–H Functionalization Methods
- Cell death mechanisms and regulation
- Iron Metabolism and Disorders
- Congenital Anomalies and Fetal Surgery
- Cardiovascular Disease and Adiposity
- Genetic Associations and Epidemiology
- Parasitic infections in humans and animals
- Parasitic Infections and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Acute Kidney Injury Research
- S100 Proteins and Annexins
- Connexins and lens biology
- Carbon dioxide utilization in catalysis
- Inflammatory mediators and NSAID effects
- Porphyrin Metabolism and Disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Signaling Pathways in Disease
- Immunodeficiency and Autoimmune Disorders
Pfizer (United States)
2012-2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Union Hospital
2023-2024
Fujian Medical University
2023-2024
Chinese Academy of Sciences
2021-2024
Institute of Genetics and Developmental Biology
2024
Chongqing Emergency Medical Center
2023
Chongqing University
2020-2023
Shihezi University
2023
Bruton's tyrosine kinase (BTK) is a member of the SRC-related TEC family protein kinases (PTKs). DT-40 lymphoma B cells, rendered BTK-deficient through targeted disruption btk gene by homologous recombination knockout, did not undergo radiation-induced apoptosis, but cells with disrupted lyn or syk genes did. Introduction wild-type, SRC homology 2 domain plecstrin mutant (but mutant), human into restored apoptotic response to radiation. Thus, BTK PTK responsible for triggering apoptosis and...
A major consequence of acute myocardial infarction is ischemia-reperfusion (I/R) injury. Collecting proof demonstrates that AXIN1 assume a basic part in different disease; however, the role I/R injury remains to great extent obscure.The model on AC16 cells was constructed. siRNA transfection used knockdown AXIN1. The qRT-PCR assays and western blot were detect expression level other key proteins. CCK-8 cell apoptosis proliferation apoptosis.AXIN1 significantly overexpressed an vitro...
Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, such this target holds significant therapeutic potential. However, over 5 years later, the function of 17B-HSD13 remains unknown. Structure-aided design enables development potent selective sulfonamide-based inhibitors. In order to probe their inhibitory potency in endogenous expression...
Osteoarthritis (OA) is a progressive degenerative joint disorder with cartilage degradation as the primary cause of pain and loss function. B-cell lymphoma-2-associated transcription factor 1 (BCLAF1) key regulator apoptosis serves signal transducer NFκB Hif-1α pathways, both which are involved in osteoarthritic degradation. However, whether BCLAF1 contributes to pathogenesis OA remains unclear. The present study aims elucidate role underlying mechanisms. We found that levels were increased...
Sickle cell disease (SCD) is a genetic disorder caused by single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled (HbS). In deoxygenated state, polymerization HbS leads to sickling red blood cells (RBC). Several downstream consequences and RBC include vaso-occlusion, hemolytic anemia, stroke. We report design noncovalent modulator HbS, clinical candidate PF-07059013 (23). The seminal hit molecule was discovered virtual screening confirmed through...
Abstract The diversity of plant inflorescence architectures is specified by gene expression patterns. In wheat ( Triticum aestivum ), the lanceolate-shaped (spike) defined rudimentary spikelets at base which initiate first but subsequently lag in development compared with central spikelets. While previous studies identified differences between and basal sections, spatio-temporal dynamics gradients along apical-basal axis remain poorly resolved due to bulk tissue-level techniques. Here, using...
Characterized by macrophage infiltration, renal inflammation during septic acute kidney injury (AKI) reveals a ubiquitous human health problem. Unfortunately, effective therapies with limited side effects are still lacking. This study is aiming to elucidate the role of Dimethyl fumarate (DMF) in macrophages against oxidative stress AKI.Balb/c mice were gavaged 50 mg/kg DMF then injected 10 LPS i.p. We examined LPS-induced dysfunction and histological features murine kidneys. Raw264.7 cells...
Syringic acid (SA) is an abundant phenolic compound that has been demonstrated to yield therapeutic benefits in myocardial and renal ischemia/reperfusion (I/R). However, the role of SA intestinal I/R injury unclear. Thus, present study aimed investigate protective effect against injury. Caco-2 cells were incubated with different doses before oxygen-glucose deprivation/reoxygenation (OGD/R) induction. The viability cells, activity lactate dehydrogenase (LDH), production pro-inflammatory...
Abstract Background Myocarditis, an inflammatory disease of the myocardium, is a serious hazard to human life due expansion lesions in myocardium. The aim this study was investigate role hypoxia-inducible transcription factor (HIF)-1α and its inhibitor topotecan pathogenesis myocarditis. Methods H9c2 cardiomyoblasts stimulated with lipopolysaccharide (LPS) simulate myocarditis model vitro. levels myocardial damage markers were determined using commercially available kits. Western blotting...
Background Although obesity is a recognized risk factor of atrial fibrillation (AF), the mechanisms are not fully understood. Objective We aimed to identify potential mediators between body mass index (BMI) and AF. Methods conducted two-sample Mendelian randomization (MR) analysis using publicly available summary-level data from genome-wide association studies. Univariable MR analyses were applied mediators, then multivariable explore mediated roles circulating biomarkers, metabolic markers...
Background/Purpose: Myocarditis is a severe disorder characterized by the inflammation of heart's muscular walls, thereby leading to sudden death in young adults. Long non-coding RNA X-inactive specific transcripts (LncRNA XIST) are class having length ˃ 200 nts with absence protein-coding abilities. They exert their function apoptosis various cancers and inflammatory diseases. background: heart walls X-inacitve transcript protein coding exerts its Objective: The current work intended...
Abstract Background Although obesity is a recognized risk factor of atrial fibrillation (AF), the mechanisms are not fully understood. Thus, we aimed to identify potential mediators between body mass index (BMI) and AF. Methods We conducted two-sample Mendelian randomization (MR) analysis using publicly available summary-level data from genome-wide association studies. Univariable MR analyses were applied mediators, then multivariable explore mediated roles circulating cytokines, metabolic...
Key words 1,2,3-triazoles - N-tosylhydrazones anilines regioselectivity copper catalysis