A5100357101- Gut microbiota and health
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Computational Drug Discovery Methods
- Plant tissue culture and regeneration
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Aldose Reductase and Taurine
- Biochemical Acid Research Studies
- Meta-analysis and systematic reviews
- Ecology and Vegetation Dynamics Studies
- Cardiovascular Function and Risk Factors
- Mechanisms of cancer metastasis
- Free Radicals and Antioxidants
- Microbial Natural Products and Biosynthesis
- AI in cancer detection
- Plant and Fungal Species Descriptions
- Ion Transport and Channel Regulation
- Horticultural and Viticultural Research
- Probiotics and Fermented Foods
- Pharmacogenetics and Drug Metabolism
- Gene expression and cancer classification
- Liver physiology and pathology
- Single-cell and spatial transcriptomics
Pfizer (United States)
2025
North China University of Science and Technology
2024
Gansu University of Traditional Chinese Medicine
2022-2024
Center for Life Sciences
2023
Tsinghua University
2023
Dalian Minzu University
2022
Harbin Institute of Technology
2021
Horizon Health Network
2021
ORCID
2021
Nanjing Agricultural University
2021
Microbial communities are believed to outperform monocultures in the complete catabolism of organic pollutants via reduced metabolic burden and increased robustness environmental challenges; however, interaction mechanism functional microbiomes remains poorly understood. Here, three functionally differentiated activated sludge (S1: sulfamethoxazole (SMX); S2: phenyl part SMX ([phenyl]-SMX) with stable accumulation its heterocyclic product 3-amino-5-methylisoxazole (3A5MI); A: 3A5MI rather...
Nucleostemin is a nucleolar protein widely expressed in proliferating cells. involved the regulation of cell proliferation, and both depletion overexpression nucleostemin induce cycle arrest through p53 signaling pathway. Although presence p53-independent functions has been previously suggested, identities these additional remained to be investigated. Here, we show that novel role as an integrated component ribosome biogenesis, particularly pre-rRNA processing. forms large complex (>700 kDa)...
Perhaps one of the most significant achievements in modern science is discovery human induced pluripotent stem cells (hiPSCs), which have paved way for regeneration therapy using patients' own cells. Cardiomyocytes differentiated from hiPSCs (hiPSC-CMs) could be used modelling patients with heart failure, testing new drugs, and cellular future. However, present cardiomyocyte differentiation protocols exhibit variable efficiency across different hiPSC lines, inhibit application this...
Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, such this target holds significant therapeutic potential. However, over 5 years later, the function of 17B-HSD13 remains unknown. Structure-aided design enables development potent selective sulfonamide-based inhibitors. In order to probe their inhibitory potency in endogenous expression...
Clinical proteomics analysis is of great significance for analyzing pathological mechanisms and discovering disease-related biomarkers. Using computational methods to accurately predict disease types can effectively improve patient diagnosis prognosis. However, how eliminate the errors introduced by peptide precursor identification protein remains a major unresolved issue. Here, we develop powerful end-to-end deep learning model, termed "MS1Former", that able classify hepatocellular...
Due to developing production methods and increasing consumption levels, improvement of fruit quality has become a focus research. Cytokinins are important hormones that affect quality. In this study, exogenous KT (Kinetin) BA (6-Benzylaminopurine) were applied 1, 3, 5, 7 9 days after pollination study the effect cytokinins on strawberry (Fragaria vesca) fruit. The results showed significantly increased weight soluble sugar content at late stages development (27 31 DAP). treatments...
The present study aimed to investigate the expression levels of components Hedgehog signaling pathway (HH) during proliferation a liver stem cell subgroup, namely small hepatocyte-like progenitor cells (SHPCs). Retrorsine-treated Fisher 344 rats underwent partial hepatectomy (PH) induce SHPCs, after which reverse transcription-polymerase chain reaction (PCR), quantitative PCR, immunohistochemistry and western blot analysis were performed analyze various HH in primary SHPCs at different times...
Abstract The extreme alpine environment around the mid‐Yalong Zangbo River on Tibetan plateau supports a unique avifauna. To understand structure and habitat selection of this poorly known bird assemblage, we quantified abundance birds in four representative types vegetation human settlement inside shrub‐covered valley (29°27′N, 91°40′E, 4000–5200 m a.s.l.) Lhasa mountains, Tibet, from September 2004 to January 2005. A total 40 species was recorded, six which were summer breeders, one...
<title>Abstract</title> Clinical proteomics analysis is of great significance for analyzing pathological mechanisms and discovering disease-related biomarkers. Using computational methods to accurately predict disease types can effectively improve patient diagnosis prognosis. However, how eliminate the errors introduced by peptide precursor identification protein remains a major unresolved issue. Here, we develop powerful end-to-end deep learning model, termed “MS1Former”, that able classify...
ABSTRACT The chemical synthesis of histones with homogeneous modifications is a potent approach for quantitatively deciphering the functional crosstalk between different post-translational (PTMs). Here, we developed an expedient site-specific (poly)ubiquitylation strategy (CAEPL, Cysteine-Aminoethylation coupled Enzymatic Protein Ligation), which integrates Cys-aminoethylation reaction process ubiquitin-activating enzyme UBA1-assisted native ligation. Using this strategy, successfully...
Abstract Squalene has been used as a dietary supplement for long history due to its potential cancer‐preventive function. However, the mechanism not investigated in detail yet. Therefore, aim of this study is see if plasma coenzyme Q10 (CoQ10) level will be altered by gavage squalene and oxidosqualenes rats. In present work, sensitive simple high‐performance analytical method based on ultra‐high‐performance liquid chromatography coupled with an Orbitrap mass spectrometry (UPLC‐Orbitrap‐MS)...
Based on polyketide syntheses gene (PKS) and non-ribosomal peptide synthetases (NRPS), one strain with high anti-pathogenic activity was screened from 77 strains isolated Arctic marine sediments identified. By optimizing the composition of culture medium fermentation conditions, production this strain's active metabolites improved main were identified by HRMS, 1H NMR 13C NMR. The antibacterial spectrum effect cucumber Fusarium wilt also determined. results showed that Bacillus velezensis it...
6639 Background: The use of acronyms in naming clinical trials has increased recent years with minimal empirical examination the effect that they have on research participants. is often a symbolic act; however, may provocative origin stimulates associations and influences perceptions research. No evidence exists to confirm supposition certain trial be coercive. purpose this study was determine if title an influence subject’s interest fictitious trial. Methods: Two scenarios (prevention...
Synthesis and biological evaluation of a novel series substituted pentacyclic triterpene derivatives as potential PPARγ agoinsts glycogen phosphorylase inhibitors have been described. Compounds 11 17 showed potent agonistic activity activated the transcription in dose-dependent manner. On other hand, eleven compounds exhibited moderate inhibitory against rabbit muscle (RMGPa), 10 was best one. Structure-activity relationship (SAR) is also discussed. Keywords: Diabetes, Glycogen inhibitors,...