A5026285240- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Connexins and lens biology
- Gut microbiota and health
- Epigenetics and DNA Methylation
- Endodontics and Root Canal Treatments
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Ferroptosis and cancer prognosis
- Oral Health Pathology and Treatment
- Oral microbiology and periodontitis research
- Cardiac Ischemia and Reperfusion
- FOXO transcription factor regulation
- TGF-β signaling in diseases
- Signaling Pathways in Disease
- Drug Transport and Resistance Mechanisms
- Periodontal Regeneration and Treatments
Gansu University of Traditional Chinese Medicine
2024-2025
University of Hong Kong
2025
Creative Commons
2023
Chongqing University
2023
Guangzhou Medical University
2019-2022
Stomatology Hospital
2019-2022
A major consequence of acute myocardial infarction is ischemia-reperfusion (I/R) injury. Collecting proof demonstrates that AXIN1 assume a basic part in different disease; however, the role I/R injury remains to great extent obscure.The model on AC16 cells was constructed. siRNA transfection used knockdown AXIN1. The qRT-PCR assays and western blot were detect expression level other key proteins. CCK-8 cell apoptosis proliferation apoptosis.AXIN1 significantly overexpressed an vitro...
Abstract Background Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a process for dentin formation, odontoblastic differentiation is regulated by complex signaling networks. The present study aimed to investigate the role and regulatory mechanisms of lncRNA-H19 (H19) regulating human dental pulp stem cells (hDPSCs). Methods We performed lncRNA microarray assay reveal expression patterns lncRNAs involved...
Abstract Aim Establishing functional circulation on time is crucial to dental pulp tissue regeneration. Mesenchymal stem cells (MSCs) could act as mural stabilize newly formed blood vessels, accelerating anastomosis. Our preliminary study found that direct coculture of (DPSCs) and human umbilical vein endothelial (HUVECs) significantly enhanced Activin A secretion. This aimed disclose the dynamic patterns expression its regulation vascular formation stabilization. Methodology DPSCs HUVECs...
Our study aimed to elucidate the regulatory molecules related osteogenic differentiation of periodontal ligament cells (PDLCs).Periodontal are a favorable source for cell-based therapy in bone engineering and regeneration due their potential multilineage ability. However, molecular mechanism signaling pathways PDLCs still unclear.Osteoblast-specific protein expression levels were examined by ELISA osteogenic-induced (induced-PDLC group). A microarray assay bioinformatics analysis carried out...
Regulated cell death is key in the pathogenesis of persistent apical periodontitis. Here, we investigated mechanisms regulated osteoblast-like MG63 cells infected with Enterococcus faecalis OG1RF.MG63 were live E. OG1RF at indicated multiplicity infection for time. We evaluated by flow cytometry, terminal deoxynucleotidyl transferase dUTP nick end labelling assay and lactate dehydrogenase release analysis; measured activity caspase-1/-3/-8/-9 interleukin-1β; determined expression...
Abstract Background Enterococcus faecalis is a dominant pathogen in the root canals of teeth with persistent apical periodontitis (PAP), and osteoblast apoptosis contributes to imbalanced bone remodelling PAP. Here, we investigated effect E. OG1RF on primary human calvarial osteoblasts. Specifically, expression apoptosis-related genes role anti-apoptotic pro-apoptotic members BCL-2 family were examined. Methods Primary osteoblasts incubated at multiplicities infection corresponding time...
Abstract Background: Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization.As a process for dentin formation, odontoblastic differentiation is regulated by complex signaling networks. The present study aimed to investigate the role and regulatory mechanisms of lncRNA-H19 (H19) regulating human dental pulp stem cells (hDPSCs). Methods: We performed lncRNA microarray assay reveal expression patterns lncRNAs involved...
Abstract Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections other systems. Much still unknown pathogenic mechanism of pulpitis. In this work, we discovered that expression miR-155 was associated with dental pulpal both vivo vitro . Experiments on odontoblast cell line MDPC-23 showed could act as positive regulator by increasing production pro-inflammatory cytokines IL-1β IL-6 during inflammatory...
Abstract Background: Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a process for dentin formation, odontoblastic differentiation is regulated by complex signaling networks. The present study aimed to investigate the role and regulatory mechanisms of lncRNA-H19 (H19) regulating human dental pulp stem cells (hDPSCs). Methods: We performed lncRNA microarray assay reveal expression patterns lncRNAs involved...
Abstract Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections other systems. Much still unknown pathogenic mechanism of pulpitis. In this work, we discovered that expression miR-155 was associated with dental pulpal both vivo vitro . Experiments on odontoblast cell line MDPC-23 showed could act as positive regulator by increasing production pro-inflammatory cytokines IL-1β IL-6 during inflammatory...