A5009429807- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- Mycobacterium research and diagnosis
- Dental Radiography and Imaging
- Endodontics and Root Canal Treatments
- MicroRNA in disease regulation
- Dental materials and restorations
- dental development and anomalies
- Mesenchymal stem cell research
- Oral Health Pathology and Treatment
- Bone and Dental Protein Studies
- Dental Implant Techniques and Outcomes
- Dental Trauma and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Oral and Maxillofacial Pathology
- Surgical Sutures and Adhesives
Guangzhou Medical University
2020-2023
Stomatology Hospital
2020-2023
Sichuan University
2010-2017
State Key Laboratory of Oral Diseases
2017
Root canal calcification is considered a great challenge during root treatment. Although the application of ultrasonic instruments and dental operating microscope (DOM) has advantages, dealing with calcified canals still suffers risk failure because limited information about location, length, direction obliteration on periapical radiographs. In this work, cone-beam computed tomography- (CBCT-) aided method aimed at solving complicated in which conventional approaches could not work was...
Abstract Background Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a process for dentin formation, odontoblastic differentiation is regulated by complex signaling networks. The present study aimed to investigate the role and regulatory mechanisms of lncRNA-H19 (H19) regulating human dental pulp stem cells (hDPSCs). Methods We performed lncRNA microarray assay reveal expression patterns lncRNAs involved...
To compare the efficacy of various irrigants (citric acid, ethylenediaminetetraacetic acid (EDTA) and NaOCl) techniques in removing Ca(OH)2 two types curved root canal systems, simulated canals with specific curvatures were used to investigate effects different instruments on removal. The optimal methods verified extracted human teeth. Simulated assigned one groups based irrigation solution: 10% citric or 2.5% NaOCl. Each group was divided into four subgroups according technique remove...
Three-dimensional (3D)-printed scaffolds are a new strategy to fabricate biomaterials for treating bone defects. Here, using 3D-printing technique, we fabricated consisting of gelatin (Gel), sodium alginate (SA), and 58S bioactive glass (58S BG). To evaluate mechanical properties biocompatibility Gel/SA/58S BG scaffolds, the degradation test, compressive strength cytotoxicity test were performed. The effect on cell proliferation in vitro was determined by 4′,6-diamidino-2-phenylindole (DAPI)...
Purpose: Teeth are exposed to various forces during functional and parafunctional movements. These processes inevitably affect the dental pulp, mechanism of these influences has been subject many previous studies using different apparatuses obtaining results. In this study, we aimed investigate effects compressive stress on proliferation differentiation human pulp cells (hDPCs).Materials Methods: A four-point bending strain system was adopted apply low-density cyclic uniaxial (2000...
Employing scaffolds containing cell–derived extracellular matrix (ECM) as an alternative strategy for the regeneration of bone defects has shown prominent advantages. Here, gelatin (Gel), sodium alginate (SA) and 58s bioactive glass (58sBG) were incorporated into deionized water to form ink, which was further fabricated composite by 3D printing technique. Then, rat aortic endothelial cells (RAOECs) or mesenchymal stem (RBMSCs) seeded on scaffolds. After decellularization, two kinds...
Abstract Background: Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization.As a process for dentin formation, odontoblastic differentiation is regulated by complex signaling networks. The present study aimed to investigate the role and regulatory mechanisms of lncRNA-H19 (H19) regulating human dental pulp stem cells (hDPSCs). Methods: We performed lncRNA microarray assay reveal expression patterns lncRNAs involved...
Abstract Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections other systems. Much still unknown pathogenic mechanism of pulpitis. In this work, we discovered that expression miR-155 was associated with dental pulpal both vivo vitro . Experiments on odontoblast cell line MDPC-23 showed could act as positive regulator by increasing production pro-inflammatory cytokines IL-1β IL-6 during inflammatory...
Abstract Background: Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a process for dentin formation, odontoblastic differentiation is regulated by complex signaling networks. The present study aimed to investigate the role and regulatory mechanisms of lncRNA-H19 (H19) regulating human dental pulp stem cells (hDPSCs). Methods: We performed lncRNA microarray assay reveal expression patterns lncRNAs involved...
Abstract Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections other systems. Much still unknown pathogenic mechanism of pulpitis. In this work, we discovered that expression miR-155 was associated with dental pulpal both vivo vitro . Experiments on odontoblast cell line MDPC-23 showed could act as positive regulator by increasing production pro-inflammatory cytokines IL-1β IL-6 during inflammatory...