A5070918040- Genetic and Kidney Cyst Diseases
- Microtubule and mitosis dynamics
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Protist diversity and phylogeny
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Photoreceptor and optogenetics research
- Luminescence Properties of Advanced Materials
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Developmental Biology and Gene Regulation
- Facial Nerve Paralysis Treatment and Research
- Circular RNAs in diseases
- Parasites and Host Interactions
- Fetal and Pediatric Neurological Disorders
- RNA regulation and disease
- Luminescence and Fluorescent Materials
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- RNA Research and Splicing
Central South University
2025
Nanjing Medical University
2021-2025
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Second Affiliated Hospital of Nanjing Medical University
2023
Motile cilia and flagellar defects can result in primary ciliary dyskinesia, which is a multisystemic genetic disorder that affects roughly 1:10 000 individuals. The nexin-dynein regulatory complex (N-DRC) links neighboring doublet microtubules within flagella, serving as central hub for motility Chlamydomonas. Herein, we identified two homozygous DRC1 variants human patients were associated with multiple morphological abnormalities of the sperm flagella (MMAF) male infertility. Drc1-/-,...
Abstract Motile cilia and flagella are evolutionarily conserved organelles, their defects cause primary ciliary dyskinesia (PCD), a disorder characterized by systemic organ dysfunction. The nexin-dynein regulatory complex (N-DRC) is crucial structural component of motile flagella, present across various species from Chlamydomonas to humans. Defects in N-DRC components lead multiple PCD symptoms, including sinusitis male infertility. However, the phenotypic expression varies significantly...
Cilia and flagella are ancient structures that achieve controlled motor functions through the coordinated interaction based on microtubules some attached projections. Radial spokes (RSs) facilitate beating motion of these organelles by mediating signal transduction between dyneins a central pair (CP) singlet microtubules. RS complex isolation from Chlamydomonas axonemes enabled detection 23 radial spoke proteins (RSP1-RSP23), although roles remain unknown. Recently, RSP15 has been reported...
Eukaryotic elongation factor-2 kinase (Eef2k) is a protein associated with the calmodulin-induced signaling pathway and an atypical alpha-kinase family member. Eef2k-mediated phosphorylation of eukaryotic translation factor 2 (Eef2) can inhibit functionality this protein, altering translation. Prior work suggests Eef2k to be overexpressed in breast, pancreatic, brain, lung cancers wherein it may control key processes apoptosis, autophagy, cell cycle progression. The functional importance...
Background/Purpose: Myocarditis is a severe disorder characterized by the inflammation of heart's muscular walls, thereby leading to sudden death in young adults. Long non-coding RNA X-inactive specific transcripts (LncRNA XIST) are class having length ˃ 200 nts with absence protein-coding abilities. They exert their function apoptosis various cancers and inflammatory diseases. background: heart walls X-inacitve transcript protein coding exerts its Objective: The current work intended...
Abstract Cilia and flagella are ancient structures that achieve controlled motor functions through the coordinated interaction of including dynein arms, radial spokes (RSs), microtubules, regulatory complex (DRC). RSs facilitate beating motion these organelles by mediating signal transduction between dyneins a central pair (CP) singlet microtubules. RS isolation from Chlamydomonas axonemes enabled detection 23 different proteins (RSP1-23), with roles RSP13, RSP15, RSP18, RSP19, RSP21...