A5103080077- Cell death mechanisms and regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- NF-κB Signaling Pathways
- Cancer-related gene regulation
- Chronic Lymphocytic Leukemia Research
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Protein Degradation and Inhibitors
- Connective Tissue Growth Factor Research
- Tumors and Oncological Cases
- Dendrimers and Hyperbranched Polymers
- Redox biology and oxidative stress
- Microscopic Colitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Genetics and Reproduction
- Thyroid Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- T-cell and Retrovirus Studies
- vaccines and immunoinformatics approaches
- Wnt/β-catenin signaling in development and cancer
Shanghai Tenth People's Hospital
2014-2023
Hebei Medical University
2021-2023
Tongji University
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2021
Second Military Medical University
2012-2017
China Medical University
2015
Shanghai Changzheng Hospital
2014-2015
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2015
Sichuan University
2012
// Song Gao 1,2 , Peng Wang Yongqiang Hua Hao Xi 3 Zhiqiang Meng Te Liu 4 Zhen Chen and Luming 1 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 2 Medical College, University, Pathology, Tenth People's Hospital, Tongji School Medicine, Geriatric Institute Chinese Longhua Traditional Correspondence to: Lu-Ming Liu, email: Chen, Keywords : incRNA, ROR, microRNA, cancer stem cells, Nanog Received June 11, 2015 Accepted November 15, Published December...
Previous population investigations have suggested that the application of curcumin may be associated with decreased incidence and improved prognosis in certain types cancer. Forkhead box O1 (FOXO1) has been implicated regulation several biological processes, including stress resistance, metabolism, DNA repair, cell cycle apoptosis. The aims present study were to investigate effects molecular mechanisms on induction anti‑proliferation, arrest apoptosis, by FOXO1, pancreatic cancer cells. MTT...
Curcumin can suppress human prostate cancer (HuPCa) cell proliferation and invasion. However, it is not known whether curcumin inhibit HuPCa stem (HuPCaSC) invasion.We used methyl thiazolyl tetrazolium Transwell assays to examine the invasion of HuPCaSC lines DU145 22Rv1 following or dimethyl sulfoxide (control) treatment. The microRNA (miRNA) expression levels in DLK1-DIO3 imprinted genomic region cells tumor tissues from patients with PCa were examined using microarray quantitative PCR.The...
Tumour cell-derived heat shock proteins (HSPs) are used as vaccines for immunotherapy of cancer patients. However, it is proposed that the peptide chaperoned on HSPs, not HSPs themselves, elicited a potent immune response. Given highly expressed by most myeloma cells and vital to cell survival, we reasoned themselves might be an ideal antigen. In present study, explored feasibility targeting treating multiple myeloma. We identified chose HLA-A*0201-binding peptides from human HSPB1 (HSP27)...
Peroxiredoxin 3 (Prx3) is a mitochondrial member of the antioxidant family thioredoxin peroxidases that uses 2 as source reducing equivalents to scavenge hydrogen peroxide (H2O2). Here, we report protein levels Prx3 are significantly reduced in VHL-deficient clear cell renal carcinoma (CCRCC). Furthermore, stabilization HIF-1α protein, caused either by VHL deficiency under normoxia, or hypoxia, expression. Luciferase-reporter and chromatin-immunoprecipitation assays indicated binds...
Unconventional prefoldin RPB5 interactor (URI), which acts as an oncoprotein in solid tumors, is associated with RNA polymerase II subunit 5. However, its impact on multiple myeloma (MM) has not been determined. We demonstrate here that URI overexpressed MM compared plasma cells derived from healthy volunteers. Side population (SP) sorted showed a much higher level of than non-SP cells. Using lentivirus-delivered shRNA, we established stable knockdown cell lines. inhibition significantly...
Arsenic trioxide (As2O3) has shown remarkable efficacy for the treatment of multiple myeloma (MM). Histone deacetylases (HDAC) play an important role in control gene expression, and their dysregulation been linked to myeloma. Especially, HDAC6, a unique cytoplasmic member class II, which mainly functions as α-tubulin deacetylase Hsp90 deacetylase, become target drug development treat cancer due its major contribution oncogenic cell transformation. However, mechanisms action As2O3 have not...
The Wnt signaling is involved in angiogenesis and tumor development. β-catenin the core component of pathway, which mediates oncogenic transcription regulated by a series proteins. Sex-determining region Y-box 7 (SOX7) member high-mobility-group factor family, inhibits lots cells with unknown mechanism. By coimmunoprecipitation (co-IP) super Topflash reporter assay, SOX7 can bind inhibit β-catenin/T cell (TCF)-mediated transcription. Meanwhile, B lymphoma 9 (BCL9) drives path through direct...
Vascular smooth muscle cell (VSMC) apoptosis is a major defining feature of abdominal aortic aneurysm (AAA) and mainly caused by inflammatory infiltration. Smooth (SM) 22 α prevents AAA formation through suppressing NF‐ κ B activation. However, the role SM22 in VSMC controversial. Here, we identified that loss contributed to VSMCs via activation macrophages. Firstly, deficiency enhanced interaction with Macrophages were retained activated Sm22α -/- upregulating VCAM‐1 expression. The ratio...
METTL3 as an m6A methyltransferase acts in diverse malignancies including gastric cancer (GC). We aimed to reveal the underlying mechanisms by which contributes carcinogenesis.The association of and SNHG3 with GC was analyzed qRT-PCR, Western blot, TCGA cohort. The functional experiments were implemented uncover role GC. dot blot MeRIP used determine METTL3-mediated modification lncRNA SNHG3. effect on SNHG3-mediated miR-186-5p/cyclinD2 axis evaluated luciferase gene report, RT-qPCR,...
Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant. Efficient control of cancer growth may substantially improve the survival PDAC patients. However, no efficient treatments are so far available. Here, we inhibited transforming factor β (TGFβ) receptor signaling by overexpression a key inhibitor this pathway, SMAD7, in mouse pancreas, using recently developed intraductal infusion method. Overexpression SMAD7 significantly increased both implanted and K-ras modification. Our data...
Pancreatic cancer is a polygenic disease and the fourth leading cause of cancer-associated mortality worldwide; however, tumorigenesis pancreatic remains poorly understood. Research at molecular level, which includes exploration biomarkers for early diagnosis specific targets therapy, may effectively aid in its stages development targeted molecular‑biological approaches treatment, thus improving prognosis. By conducting expression profiling para‑carcinoma, carcinoma relapse human tissues,...
The biological behaviors, clinical treatment, prognosis of non-muscle-invasive bladder cancers (NMIBCs) and muscle-invasive (MIBCs) are distinct. Accurate staging is pivotal in optimal therapy planning for (BCs). However, it insufficient urologists preoperative determining whether the tumor has invaded within muscularis propria through cystoscope imaging methods (CT or MRI). Therefore, searching ideal biomarkers from tissues urine important identifying MIBCs preoperatively.Differentially...
Benzo[a]pyrene (B[a]P) is a food contaminant toxic for cardiovascular diseases. The nuclear translocation of Arylhydrocarbon receptor (AhR) plays an important role in B[a]P-induced oxidative stress and vascular We confirmed that B[a]P promoted ROS production smooth muscle cells (VSMCs) vitro vivo, associated with the AhR. It known phosphorylation inhibits while dephosphorylation AhR promotes However, from posttranslational modification level, mechanism by which activates regulates unclear....
Abstract Background : MiR-218-5p is a small non-coding RNA acting as either oncogenes or tumor suppressor genes in human cancer. The expression levels of some miRNAs breast cancer plays potential role disease pathogenesis. Methods Thirty pairs invasive ductal carcinoma and adjacent specimens were included the study. Breast tissues cell lines MCF-7 MDA-MB-231 identified research line. mimics, miR-218-5p inhibitor, negative controls transfected. Specific antibodies probed with LRIG1, ErbB2,...