A5072524454- Barrier Structure and Function Studies
- Inflammation biomarkers and pathways
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Signaling Pathways in Disease
- Atherosclerosis and Cardiovascular Diseases
- Mechanical Circulatory Support Devices
- Studies on Chitinases and Chitosanases
- Chemokine receptors and signaling
- Radiopharmaceutical Chemistry and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- COVID-19 Clinical Research Studies
- Angiogenesis and VEGF in Cancer
- SARS-CoV-2 and COVID-19 Research
- Cardiac Structural Anomalies and Repair
- Ginger and Zingiberaceae research
- Cardiovascular Effects of Exercise
- Seaweed-derived Bioactive Compounds
- Fuel Cells and Related Materials
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Washington University in St. Louis
2020-2024
University of Missouri–St. Louis
2024
Chinese Academy of Sciences
2012-2024
Beijing National Laboratory for Molecular Sciences
2024
Institute of Chemistry
2024
Capital Medical University
2016-2024
University of Chinese Academy of Sciences
2009-2024
Hangzhou First People's Hospital
2023
Institute of Biophysics
2016-2023
There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes infected in patients with COVID-19 myocarditis and susceptible severe acute respiratory syndrome 2. establish an engineered heart tissue model pathology, define mechanisms pathogenesis, demonstrate cardiomyocyte 2 results contractile deficits, cytokine...
Recent studies have established that CCR2 (C-C chemokine receptor type 2) marks proinflammatory subsets of monocytes, macrophages, and dendritic cells contribute to adverse left ventricle (LV) remodeling heart failure progression. Elucidation the effector mechanisms mediate effects
Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1 (programmed cell death protein 1)/PD-L1 death-ligand 1) or CTLA4 (cytotoxic T-lymphocyte-associated 4), have revolutionized cancer management but are associated with devastating immune-related adverse events including myocarditis. The main risk factor for ICI myocarditis is the use of combination and inhibition. often fulminant pathologically characterized by myocardial infiltration T lymphocytes macrophages. Although much has...
Cardiac involvement is an important determinant of mortality among sarcoidosis patients. Although granulomatous inflammation a hallmark finding in cardiac sarcoidosis, the precise immune cell populations that comprise granuloma remain unresolved. Furthermore, it unclear how cellular and transcriptomic landscape differs from other inflammatory heart diseases.
Inflammation and tissue fibrosis co-exist are causally linked to organ dysfunction. However, the molecular mechanisms driving immune-fibroblast crosstalk in human cardiac disease remains unexplored there currently no therapeutics target fibrosis. Here, we performed multi-omic single-cell gene expression, epitope mapping, chromatin accessibility profiling 38 donors, acutely infarcted, chronically failing hearts. We identified a disease-associated fibroblast trajectory marked by cell surface...
// Juan Ma 1, * , Pan 2, Chenghai Zhao 3, Xin Xue 4 Huamin Han 5 Changzhen Liu 6 Hua Tao Weigang Xiu 1 Jia Cai Man Zhang 7 Department of Clinical Laboratory Medicine, Beijing Shijitan Hospital, Capital Medical University, Key Urinary Cellular Molecular Diagnostics, Beijing, China 2 Protein and Peptide Pharmaceuticals, Institute Biophysics, Chinese Academy Sciences, 3 Pathophysiology, College Basic Science, Shenyang, Immunology, Theory CAS Pathogenic Microbiology Microbiology, Biology,...
Immune responses contribute to a large extent heart diseases. However, it is still not clear how the key inflammatory mediator interferon-γ (IFNγ) plays role in doxorubicin (DOX)-induced cardiomyopathy. We report here that DOX-induced dysfunction involves IFNγ signaling mice. The receptor was found be highly expressed on cardiomyocytes, and its downstream activated tissues upon DOX treatment. In vitro, strongly aggravated injury of cardiomyocytes exposed DOX. Although affecting cell death,...
BACKGROUND: Immune checkpoint inhibitor (ICI) usage has resulted in immune-related adverse events patients with cancer, such as accelerated atherosclerosis. Of immune cells involved atherosclerosis, the role of CCR2+ (CC motif chemokine receptor 2-positive) proinflammatory macrophages is well documented. However, there no noninvasive approach to determine changes these vivo following ICI treatment and explore underlying mechanisms events. Herein, we aim use a CCR2 2)–targeted radiotracer...
Abstract Semicrystalline polymers exhibit complex structural evolution during uniaxial stretching, including the formation of cavities, which significantly affect their material properties. However, in‐depth studies are still lacking in understanding early stage cavitation due to limitations existing techniques. This study presents a detailed investigation early‐stage isotactic polypropylene ( i PP) stretching using SEM‐based situ observations, provides real‐time, high‐resolution...
Adoptive transfer of NK cells has been widely applied clinically for cancer immunotherapy. However, the difficulties to obtain a large number activated impede successful application such therapy. In present study, we implemented novel method involving use immobilized human 4-1BBL and interleukin-21 amplify from peripheral blood mononuclear (PBMCs) healthy donors. Following stimulation 21 days, achieved considerable expansion with high purity strong cytotoxicity. This is first time solid...
Abstract Cardiac fibrosis is causally linked to heart failure pathogenesis and adverse clinical outcomes. However, the precise fibroblast populations that drive in human mechanisms govern their emergence remain incompletely defined. Here, we performed Cellular Indexing of Transcriptomes Epitomes by sequencing (CITE-seq) 22 explanted hearts from healthy donors, acute myocardial infarction (MI), chronic ischemic non-ischemic cardiomyopathy patients. We identified a trajectory marked activator...
Targeting HER2 overexpressed breast cancer cells with anti‑HER2 monoclonal antibodies inhibits tumor growth. Here we investigated whether can serve as a target for T cell‑mediated immunotherapy of human colorectal carcinoma. Specific cytolytic activity activated (ATCs) armed anti‑CD3 x bispecific antibody (HER2Bi‑Ab) against HER2+ was evaluated by bioluminescent signal generated luciferase reporter on in vitro and vivo. In contrast to unarmed ATCs, increased cytotoxic HER2Bi‑armed ATCs...
Angiostasis mediated by interferon (IFN)-γ is a key mechanism of anti-tumour immunity; however, the effect IFN-γ on host vascular endothelial growth factor A (VEGFA)-expressing cells during tumour progression still elusive. Here, we developed transgenic mice with receptor (IFNγR) expression under control Vegfa promoter (V-γR). In these mice, responsiveness VEGFA-expressing led to dramatic suppression transplanted lung carcinoma cells. Surprisingly, increased mortality and metastasis were...
This study explored the effectiveness of a Problem-based Learning (PBL) teaching model on WeChat public platform for radiation oncology residency training programs.