A5003681797- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Fatty Acid Research and Health
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Muscle metabolism and nutrition
- Cardiac Fibrosis and Remodeling
- Cardiac pacing and defibrillation studies
- Infant Nutrition and Health
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Diet and metabolism studies
- Digestive system and related health
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Nutritional Studies and Diet
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Crystallization and Solubility Studies
Washington University in St. Louis
2017-2025
Hospital Del Mar
2016-2024
Hospital del Mar Research Institute
2016-2024
Universitat Autònoma de Barcelona
2016-2022
Higher University of San Andrés
2019-2022
Cardiovascular Research Center
2020
Universidad de Huelva
2018
Municipal Institute for Medical Research
2016
Albert Einstein College of Medicine
2011-2013
University of Puerto Rico-Mayaguez
2013
Immune checkpoint inhibitors (ICIs), antibodies targeting PD-1 (programmed cell death protein 1)/PD-L1 death-ligand 1) or CTLA4 (cytotoxic T-lymphocyte-associated 4), have revolutionized cancer management but are associated with devastating immune-related adverse events including myocarditis. The main risk factor for ICI myocarditis is the use of combination and inhibition. often fulminant pathologically characterized by myocardial infiltration T lymphocytes macrophages. Although much has...
BACKGROUND: Right ventricular apical pacing (RVAP) can produce left ventricle dysfunction. Conduction system (CSP) has been used successfully to reverse dysfunction in patients with bundle branch block. To date, data about CSP prevention of preserved ejection fraction (LVEF) are scarce and limited mostly nonrandomized studies. Our aim is demonstrate that preserve normal function compared RVAP the setting a high burden pacing. METHODS: Consecutive high-degree atrioventricular block or mildly...
Sex steroids control the proliferation of their target cells through two different pathways: 1) proliferative response (Step-1); and 2) inhibition cell (Step-2). Mechanisms regulation are incompletely understood; however, there is general agreement with notion that sex steroid receptors play an important role in cells. To test this hypothesis, a full human androgen receptor (AR) vector was transfected into breast cancer MCF7 The cloned stably express AR, called MCF7-AR1 cells, contained...
During the COVID-19 pandemic, concern regarding its effect on management of non-communicable diseases has been raised. However, there are no data impact cardiac implantable electronic devices (CIED) implantation rates. We aimed to determine SARS-CoV2 monthly incidence rates and type pacemaker (PM) defibrillator (ICD) implantations in Catalonia before after declaration state alarm Spain 14 March 2020.Data new CIED for 2017-20 were prospectively collected by nine hospitals Catalonia. A mixed...
We performed indirect intracoronary delivery of adenovirus vectors in mice and explored techniques including hypothermia pharmacological means to increase cardiac gene transfer. Mice were maintained a normothermic state or cooled 25 degrees C. The aorta both the pulmonary artery clamped while needle was advanced into left ventricular cavity deliver encoding enhanced green fluorescent protein (EGFP) murine adenylyl cyclase type VI (AC(VI)) with saline, sodium nitroprusside, acetylcholine,...
Glycogen synthase kinase 3 (GSK-3) inhibition has emerged as a potential therapeutic target for several diseases, including cancer. However, the role GSK-3 regulation of human cardiac electrophysiology remains ill-defined. We demonstrate that SB216763, inhibitor, can acutely reduce conduction velocity in slices. Combined computational modeling and experimental approaches provided mechanistic insight into inhibition-mediated changes, revealing decreased sodium-channel conductance tissue...
Patients with chronic mountain sickness (CMS) have a high hemoglobin concentration [Hb] due to increased mass (Hbmass) and possibly reduced plasma volume (PV). The values of Hbmass, PV blood (BV) been described differently, the relationships between Hbmass or are poorly understood. This study obtained representative BV data from healthy, high-altitude residents CMS patients quantified dependency on PV.Eighty-seven subjects born at altitude (∼3,900 m) were enrolled. Thirty-four had (CMS), 11...
Abstract Background Immune checkpoint inhibitor (ICI) myocarditis is associated with high morbidity and mortality. While endomyocardial biopsy (EMB) considered a gold standard for diagnosis, the sensitivity of EMB not well defined. Additionally, pathological features that correlate clinical diagnosis ICI-associated remain incompletely understood. Methods We retrospectively identified reviewed clinicopathological 26 patients suspected based on institutional major minor criteria. Seventeen...
What is the central question of this study? Is it necessary to modify CO-rebreathing method acquire reliable measurements haemoglobin mass in patients with chronic mountain sickness? main finding and its importance? The must be modified because prolonged CO-mixing time sickness. After adaptation blood sampling method, valid results were attained. With modification, possible quantify extent polycythaemia distinguish between a haemoconcentration an exclusive enhancement erythrocyte...
Mutations in cardiac troponin T (cTnT), Δ160E and R92Q, have been linked to familial hypertrophic cardiomyopathy (FHC), some studies indicated that these mutations can lead a high incidence of sudden death the relative absence significant ventricular hypertrophy. Alterations autonomic function documented patients with cardiomyopathy. We hypothesize alterations may contribute mutation-specific clinical phenotypes cTnT-related FHC. Heart rate (HR) variability (HRV) has used assess from an...
The thin filament protein troponin T (TnT) is a regulator of sarcomere function. Whole heart energetics and contractile reserve are compromised in transgenic mice bearing missense mutations at R92 within the tropomyosin-binding domain cTnT, despite being distal to ATP hydrolysis myosin. These associated with familial hypertrophic cardiomyopathy (FHC). Here we test hypothesis that genetically replacing murine αα-MyHC ββ-MyHC hearts R92Q cTnT mutation, particularly lethal FHC-associated leads...