A5060897754- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Quinazolinone synthesis and applications
- Crystallization and Solubility Studies
- Synthesis of heterocyclic compounds
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Organometallic Complex Synthesis and Catalysis
- Liquid Crystal Research Advancements
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Molecular spectroscopy and chirality
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- DNA and Nucleic Acid Chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antimicrobial Resistance in Staphylococcus
- Fluorine in Organic Chemistry
- Synthetic Organic Chemistry Methods
- Synthesis and properties of polymers
- Synthesis of Organic Compounds
- Antifungal resistance and susceptibility
- Chemical Synthesis and Reactions
University of Puerto Rico-Mayaguez
2012-2023
University of Puerto Rico System
2006-2020
Universidad Nacional Autónoma de México
1995-2019
Departamento de Salud
2019
InterAmerican University of Puerto Rico
1996-2018
University of Puerto Rico at Río Piedras
2015
Nagoya University
1999
Emory University
1999
Universidad de Zaragoza
1983-1995
Instituto de Nanociencia y Materiales de Aragón
1991
Nanoparticles have been used to transport drugs various body parts treat cancer. Our interest is in gold nanoparticles (AuNPs) since they the capacity absorb light and convert it heat, inducing cellular damage. This property known as photothermal therapy (PTT) has studied cancer treatment. In present study, biocompatible citrate-reduced AuNPs were functionalized with a biologically active compound, 2-thiouracil (2-TU), of potential anticancer activity. Both unfunctionalized (2-TU-AuNPs)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTcis- and trans-Diene coordination in ruthenium(II) acetylacetonate compoundsRichard D. Ernst, Enrique Melendez, Lothar Stahl, Manfred L. ZieglerCite this: Organometallics 1991, 10, 3635–3642Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://pubs.acs.org/doi/10.1021/om00056a039https://doi.org/10.1021/om00056a039research-articleACS PublicationsRequest reuse permissionsArticle...
Three ferrocene complexes vectorized with estrogens and vitamin D2 were synthesized fully characterized by spectroscopic, electrochemical computational methods. The synthesis of these esters was accomplished reacting ferrocenoyl chloride the corresponding ROH groups (R = ergocalciferol, estradiol, estrone). cytotoxicity in HT-29 colon cancer MCF-7 breast cell lines investigated vitro. Only 17β-hydroxy-estra-1,3,5(10)-trien-3-olate showed good cytotoxic activity both lines, exceeding those...
Abstract Three homologous series of α,α′-Dimethylbenzalazines, have been synthesized: 4,4′-Dialkoxy-α,α′-Dimethylbenzalazines, 4,4′-dialkoxy-2,2′-dihydroxy-α,α′-Dimethylbenzalazines, and 4,4′-dialkoxy-2-hydroxy-α,α′-Dimethylbenzalazines. The influence molecular structure on the mesomorphic properties was studied. Mesomorphic phase transitions were determined using a polarizing hotstage microscope differential scanning calorimeter. introduction one or two hydroxyl groups in position 2- 2-and...
Previously, ferrocene incorporation into the principal structural component of biologically active molecules resulted in enhanced cytotoxic activity against hormone-dependent MCF-7 and T-47D hormone-independent MDA-MB-231 breast-cancer cell lines. Here we explore 4 new estrogen conjugates at position 16 hormone compared them to previously reported conjugate 3-ferrocenyl-estra-1,3,5(10)-triene-17β-ol. The 16-ferrocenylidene-3-hydroxyestra-1,3,5(10)-trien-17-one was synthesized using estrone...
Direct comparison of the cyclopentadienyl ligand with its open-chain counterpart has been accomplished using complex 1, which contains both ligands. The Ti-C bonds to acyclic are 0.106 Å shorter than those cyclic ligand. Although this finding indicates that pentadienyl stronger, reaction 1 acetonitrile occurs nonetheless at aromatic character C5H offers a possible explanation for apparent contradiction. aromaticity results in resistance chemical change; is, formation stronger and coupling...
Abstract Two homologous series of benzalazines were synthesized, namely, the 4,4′-di-n-alkoxy-2-hydroxybenzalazines and 4,4′-di-n-alkoxybenzalazines, their mesomorphic properties studied. All prepared compounds these exhibit mesomorphism some them possess crystalline polymorphism also. A comparative study with those 4,4′-di-n-alkoxy-2,2′-dihydroxybenzalazines analogous α,α'-dimethylbenzalazines was carried out in order to determine influence central core on properties.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPentadienyl as a Stronger Binding but More Reactive Ligand Than Cyclopentadienyl: Syntheses, Reactions, and Molecular Orbital Studies of Half-Open TitanocenesIsabella Hyla-Kryspin, Thomas E. Waldman, Enrique Melendez, Wimonrat Trakarnpruk, Atta M. Arif, Manfred L. Ziegler, c Richard D. Ernst, Rolf GleiterCite this: Organometallics 1995, 14, 11, 5030–5040Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published...
A series of ferrocenyl ester complexes, varying the lipophilic character pendant groups, was prepared and characterized by spectroscopic analytical methods. The syntheses Fe(C(5)H(4)CO(2)CH(3))(2), Fe(CpCOOCH(3)) (CpCOO CH(2)CH(3)), Fe(CpCOOCH(2)CH(3))(2) are reported. solid-state structure Fe(C(5)H(4)CO(2)CH(3))(2) has been determined X-ray crystallography. cyclopentadienyl rings virtually in an eclipsed conformation with groups not completely opposite to each other. Cyclic voltammetry...