A5103521963- Bone health and osteoporosis research
- Bone health and treatments
- Hip and Femur Fractures
- Bone Metabolism and Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Polyamine Metabolism and Applications
- Occupational Health and Safety Research
- Agriculture and Farm Safety
- Rabies epidemiology and control
- Medication Adherence and Compliance
- Neurobiology and Insect Physiology Research
- Pharmaceutical Economics and Policy
- Bone and Joint Diseases
- Workplace Health and Well-being
- Insurance and Financial Risk Management
- Advanced Causal Inference Techniques
- Pharmaceutical Practices and Patient Outcomes
- Cervical and Thoracic Myelopathy
- Pharmacological Effects and Toxicity Studies
- Lipoproteins and Cardiovascular Health
- Orthopedic Infections and Treatments
- Ferroptosis and cancer prognosis
- Venomous Animal Envenomation and Studies
Amgen (United States)
2014-2025
Stowers Institute for Medical Research
2016
Procter & Gamble (United States)
2008-2012
University of Iowa
2010
Massachusetts Academy of Math and Science
2009
ABSTRACT In this international study, we examined the incidence of hip fractures, postfracture treatment, and all‐cause mortality following based on demographics, geography, calendar year. We used patient‐level healthcare data from 19 countries regions to identify patients aged 50 years older hospitalized with a fracture 2005 2018. The age‐ sex‐standardized rates post‐hip treatment (defined as proportion receiving anti‐osteoporosis medication various mechanisms action [bisphosphonates,...
OBJECTIVE: Epidemiological studies have shown that mental disorders are associated with reduced health-related quality of life, high levels health care utilization, and work absenteeism. However, measurement the burden by using population-based methods in large working populations, such as U.S. military, has been limited. METHOD: Analysis hospitalizations among all active-duty military personnel (16.4 million person-years) from 1990 to 1999 ambulatory visits 1996 was conducted Defense...
Introduction Hip fractures are associated with a high burden of morbidity and mortality. Globally, there is wide variation in the incidence hip fracture people aged 50 years older. Longitudinal cross-geographical comparisons health data can provide insights on aetiology, risk factors, healthcare practices. However, systematic reviews studies that use different methods study periods do not permit direct comparison across geographical regions. Thus, objective this to investigate global secular...
Most subjects in osteoporosis clinical trials were women with postmenopausal and while bridging studies (BMD endpoint) provide an expectation that medications will reduce fracture risk men. This real-world study shows direct evidence of reduction among men (36% hip denosumab). Direct for used is very limited. aims to evaluate the effectiveness denosumab reducing risk. included 13,797 aged ≥ 50 years who had initiated Taiwan. Taiwan's National Health Insurance Research Database includes all...
Abstract Objective Prior observational studies have shown an association between bisphosphonate adherence and fewer fractures. It is unclear if such reflect pharmacologic benefits or behavioral attributes, i.e., the healthy adherer effect. Our objective was to examine of therapy fracture risk among patients initiating therapies hypothesized be favorable, unfavorable, neutral toward risk, in order evaluate for a Methods In this study, we identified within Medicare 2006–2009 data who initiated...
ABSTRACT Certified Safe Farm (CSF) is a multifaceted intervention including clinical Occupational and wellness screening, education, on-farm safety audits with set standards, performance incentives. Five years of respiratory health outcomes are reported in 150 CSF farmers 158 matched controls. Standardized interviews occupational histories were analyzed descriptive statistics to determine prevalence rates. There was 100% response rate from the standardized telephone interviews, respectively...
Objectives: Little is known about the disposition of severe patients prior to treatment escalation. To classify by step using pharmacy data and describe their economic healthcare utilization, insurance status, sociodemographic characteristics in year escalation Global Initiative for Asthma (GINA) steps 4 5. Methods: This was a retrospective claims cohort study asthma (age 12–75 years) newly initiated on “stable therapy” (three consecutive months therapy) with omalizumab, high intensity...
Real-world data are needed to understand the effectiveness of new therapeutic options for low-density lipoprotein cholesterol (LDL-C) reduction in Asia-Pacific clinical practice. Description evolocumab use among adults with establisHed Atherosclerotic cardiovascuLar diseasE or hypercholesterolemia ASia-Pacific region (HALES) was performed better characteristics and decision-making established atherosclerotic cardiovascular disease/hypercholesterolemia after local approval.
Reward perception guides all aspects of animal behavior. However, the relationship between perceived value a reward, latent and behavioral response remains unclear. Here we report that, given choice two sweet chemically similar sugars—L- D-arabinose—Drosophila melanogaster prefers D- over L- arabinose, but forms long-term memories L-arabinose more reliably. Behavioral assays indicate that L-arabinose-generated require sugar receptor Gr43a, calcium imaging electrophysiological recordings...
Abstract On June 23, 2020, Prolia ® (denosumab) was approved by the National Medical Products Administration (NMPA) in People’s Republic of China as first monoclonal antibody for treatment postmenopausal women with osteoporosis at high risk fractures. Its brand name Chinese is 普罗力, a transliteration from English “Prolia”, which has an implied meaning “to give strength to everyone”— suitable potent anti-resorptive therapy. The approval supported novel marketing authorization application (MAA)...
e20513 Background: Lung cancer is the leading cause of death in Taiwan. The poor prognosis lung patients with advanced disease and recent development precision medicine motivates investigation molecular targets. purpose study to estimate prevalence KRAS gene mutations 15 other targets among non-small cell (NSCLC) Methods: This retrospective included 933 NSCLC diagnosed between January 1992 July 2018 at six medical centers Taiwan, including Taichung Veteran’s General Hospital, Chung San...