A5101838070- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Biochemical and Structural Characterization
- Chemical synthesis and alkaloids
- Cancer therapeutics and mechanisms
- Phytochemical compounds biological activities
- Sphingolipid Metabolism and Signaling
- Immune Response and Inflammation
- Bioinformatics and Genomic Networks
- Synthesis and Biological Evaluation
- Antifungal resistance and susceptibility
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Natural product bioactivities and synthesis
- Microbial Metabolic Engineering and Bioproduction
- Sulfur-Based Synthesis Techniques
- Autophagy in Disease and Therapy
- Fungal Infections and Studies
- AI in cancer detection
- Pediatric health and respiratory diseases
- MRI in cancer diagnosis
- Histone Deacetylase Inhibitors Research
- Carbohydrate Chemistry and Synthesis
- Plant biochemistry and biosynthesis
University of South Carolina
2021-2025
Beijing Academy of Artificial Intelligence
2021
University of Groningen
2020
Fujian Medical University
2019
Union Hospital
2019
Second Military Medical University
2015
Abstract Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on hidden enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application lanthipeptides are frequently hindered by unclustered protease genes required final maturation. Here, we establish a global correlation network bridging gap between lanthipeptide precursors proteases. Applying our analysis 161,954 bacterial genomes, 5209 correlations...
Class III lanthipeptides are an emerging subclass of lanthipeptides, representing underexplored trove new natural products with potentially broad chemical diversity and important biological activity. Bioinformatic analysis class lanthipeptide biosynthetic gene cluster (BGC) distribution has revealed their high abundance in the phylum Firmicutes. Many these clusters also feature methyltransferase (MT) genes, which likely encode uncommon lanthipeptides. However, two hurdles, silent BGCs...
Sulfonolipids (SoLs) are a unique class of sphingolipids featuring sulfonate group compared to other sphingolipids. However, the biological functions and biosynthesis SoLs in human microbiota have been poorly understood. Here, we report discovery isolation from opportunistic pathogen Chryseobacterium gleum DSM16776. We show for first time pro-inflammatory activity with mice primary macrophages. Furthermore, used both vivo heterologous expression vitro biochemical reconstitution characterize...
Sulfation is a widely used strategy in nature to modify the solubility, polarity, and biological activities of molecules. The enzymes catalyzing sulfation, sulfotransferases (STs), are typically highly specific single sulfation site molecule. Herein, identification characterization sulfated adipostatins reported reveals novel sulfotransferase, AdpST, which responsible for di-sulfation at two sites adipostatins. initial bioinformatic analysis search adipostatin analogs from Streptomyces...
Lasso peptides are an increasingly relevant class of peptide natural products with diverse biological activities, intriguing physical properties, and unique chemical structures. Most characterized lasso have been from Actinobacteria Proteobacteria, despite bioinformatic analyses suggesting that other bacterial taxa, particularly those Firmicutes, rich in biosynthetic gene clusters (BGCs) encoding peptides. Herein, we report the identification a BGC Paenibacillus taiwanensis DSM18679 which...
The anti-malarial drug artemisinin, produced naturally in the plant Artemisia annua, experiences unstable and insufficient supply as its production relies heavily on source. To meet massive demand for this compound, metabolic engineering of microbes has been studied extensively. In study, we focus improving amorphadiene, a crucial artemisinin precursor, Bacillus subtilis. expression level plant-derived amorphadiene synthase (ADS) was upregulated by fusion with green fluorescent protein...
While marine natural products have been investigated for anticancer drug discovery, they are barely screened against rare cancers. Thus, in our effort to discover potential leads the cancer pseudomyxoma peritonei (PMP), which currently lacks effective treatments, we extracts of actinomycete bacteria PMP cell line ABX023-1. This led isolation nine rearranged angucyclines from Streptomyces sp. CNZ-748, including five new analogues, namely, grincamycins P-T (1-5). The chemical structures these...
Lung cancer is considered to be one of the world's deadliest diseases, with non‑small cell lung (NSCLC) accounting for 85% all cases. The present study aimed investigate role and underlying mechanisms interleukin‑21 (IL‑21), its receptor IL‑21R, in NSCLC. tissues blood samples NSCLC were used measure IL‑21, IL‑21R programmed death 1 ligand (PD‑L1) expression using ELISA, western blot immunohistochemistry analyses. Following treatment different doses proliferation, invasion migration human...
Abstract Life’s organic molecules are built with diverse functional groups that enable biology by fine tuning intimate connections through time and space. As such, the discovery of new-to-nature can expand our understanding natural world motivate new applications in biotechnology biomedicine. Herein we report genome-aided sulfenicin, a novel polyketide-nonribosomal peptide hybrid product from marine Streptomyces bacterium bearing unique acylsulfenic acid functionality. Through series...
Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for treatment that uses a chemical drug to achieve the efficacy both chemotherapy and immunotherapy. Herein, we report high-throughput screening platform subsequent discovery new class chemotherapeutic leads. Our integrates informatics-based activity metabolomics rapid identification microbial natural products with novel structures potent activities. Additionally, demonstrate use microcrystal...
To the Editor: Mucormycosis and aspergillosis are opportunistic fungal infections that can lead to life-threatening complications.[1,2] Pulmonary actinomycosis is a rare infection which commonly confused with other lung diseases.[3] Co-infection these three pathogens in same host rare. Here, we report unique case of cavitary lesion aspergillosis, mucormycosis, co-infection. A 52-year-old male patient type 2 diabetes presented at Fujian Medical University Union Hospital 2-month history fever,...
Abstract Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly promising direction for treatment that uses a chemical drug to achieve the efficacy both chemotherapy and immunotherapy. Herein we report high-throughput screening platform subsequent discovery new class chemotherapeutic leads. Our integrates informatics-based activity metabolomics rapid identification microbial natural products with novel structures potent activities. Additionally, demonstrate use...
Abstract The trillions of microorganisms inhabiting the human gut are intricately linked to health. At species abundance level, correlational studies have connected specific bacterial taxa various diseases. While abundances these bacteria in serve as good indicators for disease progression, understanding functional metabolites they produce is critical decipher how microbes influence Here, we report a unique biosynthetic enzyme-guided correlation approach uncover microbial potential molecular...
Abstract Bacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on cryptic enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application lanthipeptides are frequently hindered by proteases required final maturation. Here, we establish a global correlation network bridging gap between lanthipeptide precursors proteases. Applying our analysis 161,954 bacterial genomes, 5,209 correlations proteases, with 91...