A5039769478- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Drug Transport and Resistance Mechanisms
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Synthesis and Biological Activity
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Apelin-related biomedical research
- Ion channel regulation and function
- Pancreatic and Hepatic Oncology Research
- Nitric Oxide and Endothelin Effects
- Hormonal Regulation and Hypertension
- Plant Toxicity and Pharmacological Properties
- PARP inhibition in cancer therapy
- Endoplasmic Reticulum Stress and Disease
- Erythrocyte Function and Pathophysiology
- Marine Sponges and Natural Products
- RNA modifications and cancer
- DNA Repair Mechanisms
- Sirtuins and Resveratrol in Medicine
- Estrogen and related hormone effects
- Adenosine and Purinergic Signaling
Chinese University of Hong Kong
1997-2023
Hepatocellular carcinoma (HCC) is a deadly form of cancer without effective chemotherapy so far. Currently, only sorafenib, multitargeted tyrosine kinase inhibitor, slightly improves survival in HCC patients. In searching for natural anti-HCC components from toad venom, which frequently used the treatment liver traditional Chinese medicine, we discovered that arenobufagin, bufadienolide had potent antineoplastic activity against HepG2 cells as well corresponding multidrug-resistant HepG2/ADM...
ClC-3 chloride (Cl–) channel has been shown to be involved in cell proliferation, cycle, and migration processes. Herein, we found that a series of bufadienolides isolated from toad venom were novel class Cl– activators with antitumor activities. Bufalin, which the most potent activity, 15β-acetyloxybufalin, no chosen as representative compounds investigate role channel. It was bufalin rapidly elicited activation subsequently induced apoptosis through inhibition PI3K/Akt/mTOR pathway. The...
Background/Aims: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. At present, only sorafenib approved to treat HCC. In this study, we found that a 23-hydroxybetulinic acid derivative, B4G2, exhibited potent antiproliferative activity in HCC cell lines. Methods: We used four lines (HepG2, HepG2/ADM, Hep3B and Bel-7402) evaluate anti-tumour explore underlying mechanisms by which B4G2 induces apoptosis. Results: Among these lines, HepG2 showed highest sensitivity B4G2....
Multidrug resistance (MDR) is a major obstacle to successful chemotherapy for cancer; thus, novel MDR reversers are urgently needed. In the present study, we assessed whether two synthetic derivatives of 23-hydroxybetulinic acid, 3,23-O-diacetyl-17-1,4′-bipiperidinyl betulinic amide (DABB) and 3,23-O-dihydroxy-17-1,4′-bipiperidinyl (DHBB), could reverse induced by ATP-binding cassette (ABC) transporters. Using MTT assay, found that DABB DHBB enhance cytotoxicities ABCB1 substrates...
Anemoside A3, a lupane-type triterpenoid saponin, exists in the roots of Pulsatilla chinensis, but its pharmacological properties are largely unknown. The present study aimed to investigate mechanisms underlying anemoside A3-induced relaxation rat renal arteries. Changes isometric force were determined on arteries with myograph. A3 caused concentration-dependent precontracted aortas, mesenteric, left coronary, and Removal endothelium or treatment charybdotoxin plus apamin slightly...
Abstract Background and Objective: Tumor angiogenesis process is regulated by multiple proangiogenic pathways, such as VEGFR2 Axl. Inhibition of VEGF/VEGFR2 signaling alone fails to block tumor neovascularization, anti-VEGF resistance often associated with Hence, discovery novel agents that target pathways in demand. Here, we describe desacetylvinblastine monohydrazide (DAVLBH), a derivative vinblastine (VLB) exerts more potent antiangiogenic effect than VLB vitro vivo inhibiting Axl...