A5100331487- Synthesis of Organic Compounds
- Wound Healing and Treatments
- Synthesis and biological activity
- Medical Research and Treatments
- Multicomponent Synthesis of Heterocycles
- Translation Studies and Practices
- Synthesis of Indole Derivatives
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Malaria Research and Control
- Microwave-Assisted Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Alzheimer's disease research and treatments
- Burn Injury Management and Outcomes
- Healthcare and Venom Research
- Fetal and Pediatric Neurological Disorders
- Drug Solubulity and Delivery Systems
- Cancer therapeutics and mechanisms
- SARS-CoV-2 detection and testing
- Hepatitis C virus research
- Chemical Synthesis and Reactions
- Synthesis and Biological Activity
- Microencapsulation and Drying Processes
- Neonatal and Maternal Infections
- Renin-Angiotensin System Studies
Affiliated Hospital of Nantong University
2025
Nantong University
2024-2025
Jiangnan University
2011-2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2024
Affiliated Hospital of Southwest Medical University
2024
Weatherford College
2024
Wannan Medical College
2024
Second People's Hospital of NanTong
2024
Suzhou Municipal Hospital
2023
Supramolecular construction of multistimuli platform for drug delivery is a challenging task. In this work, pH and GSH (glutathione) dual-responsive bola-type supramolecular amphiphile was successfully fabricated by the complexation between water-soluble pillar[5]arene (WP5) bolaform naphthalimide guest (G) in water. The resulting further self-assembled into binary vesicles, which could be disassembled low pH, high-GSH-concentration environment, or both. Furthermore, results loading...
Abstract Pulmonary arterial endothelial cells (PAEC) are mechanistically linked to origins of pulmonary hypertension (PAH). Here, global proteomics and phosphoproteomics PAEC from PAH ( n = 4) healthy lungs 5) were performed using LC-MS/MS confirm known pathways identify new areas investigation in PAH. Among control cells, 170 proteins 240 phosphopeptides differentially expressed; these, 45 18 located the mitochondria. Pathologic identified with integrative bioinformatics human...
Background Metabolic syndrome (MetS) is on the rise in developing countries and characterized by a series of indications metabolic disturbance. However, prevalence MetS varies under different definitions. The study aimed to compare five definitions China adult population, explore their prevalence, characteristics agreement. Methods data for retrospective came from Health Retirement Longitudinal Study (CHARLS), consisting 9,588 participants (≥45). International Diabetes Federation (IDF)...
An efficient and available material for promoting skin regeneration is of great importance public health, but it remains an elusive goal. Inspired by fetal scarless wound healing, we develop a wearable biomimetic film (WBMF) composed hyaluronan (HA), vitamin E (VE), dopamine (DA), β-cyclodextrin (β-CD) that mimics the context (FC) extracellular matrix (ECM) around bed dermal regeneration. First, WBMF creates FC sterility, hypoxia, persistent moisture, no secondary insults wounds as result...
ABSTRACT Objective This study aimed to assess the impact of ventricular septal defect (VSD) on fetal cardiac geometry and systolic function during second trimester using Fetal Heart Quantification (Fetal HQ) technology. Methods In this prospective study, 91 fetuses with isolated VSD gestational age‐matched healthy controls were evaluated. Using GE Voluson E10 ultrasound system HQ software, parameters such as global sphericity index (GSI), longitudinal strain (GLS), ejection fraction (EF),...
Children with cerebral palsy (CP) are faced long-term dysfunction. The International Classification of Functioning, Disability and Health for Youth (ICF-CY) has been proposed but the complicated procedure limits feasibility clinical application exploration health degrees. This study was aimed to establish a Mokken scale based on ICF-CY CP, then estimate psychometric properties through derived Rasch model. 150 children CP were assessed by categories "b" "d" components in core set. binarized...
Abstract Background Given the relatively high prevalence of vision impairment and heterogeneity visual changes among elderly population, we aimed to identify trajectories examine predictors consequences associated with each trajectory class. Methods We analysed data from 2235 participants involved in 5th, 6th, 7th, 8th waves Chinese Longitudinal Healthy Longevity Survey (CLHLS), where was evaluated using an adapted Landolt-C chart during wave. employed a growth mixture model (GMM) distinct...
Abstract Burn wound healing remains a challenging health problem worldwide due to the lack of efficient and precise therapy. Inherent oxidative stress following burn injury is importantly responsible for prolonged inflammation, fibrotic scar, multiple organ failure. Herein, bioinspired antioxidative defense system coupling with in situ forming hydrogel, namely, multiresponsive injectable catechol‐Fe 3+ coordination hydrogel (MICH) matrix, engineered promote burn‐wound dermal repair by...
Occupational carcinogens, smoking, and obesity are believed to be the main causing agents of kidney cancer. China is undergoing rapid industrialization, hence people's lifestyles have witnessed tremendous changes. However, trend cancer incidence during late 20
Promoting a drug inclusion proportion in hydrophobic cavity of β-cyclodextrin using simple methods is highly ambitious task. Herein, we report the crowning β-cyclodextrins formed by intramolecular hydrogen bonding interaction, which has greatly prolonged depth β-cyclodextrin, and therefore further efficiently improved to complex molecule (vitamin E). Furthermore, self-assembly behaviors, controllable release, antioxidant properties vitamin E embedded into was investigated, host-guest...
BackgroundThe persistent presence of inflammation is a recognized pathogenic mechanisms diabetic foot ulcers (DFUs). We aimed to investigate the expression PLIN1 in tissues from DFU patients and assess its potential association with inflammation-induced damage.MethodsWe performed transcriptome sequencing correlation analysis skin or without DFUs. Additionally, we examined between related inflammatory indicators by analyzing tissue serum samples through high-glucose stimulation keratinocytes...
The study was designed to discover the biological function of endotheliocyte-derived microparticles in diabetes condition. A quantitative shotgun proteomics methodology performed proteome these high-glucose-activated endothelial microparticles. total 1428 proteins were identified, containing 1421 and 1423 control high-glucose groups, respectively. According ExoCarta database, 669 have previously been identified associated with disease this study, notably, 30 reported be Alzheimer’s disease,...
Square wave voltammetry is used in this work to detect human islet amyloid polypeptide (hIAPP) by using the oxidized signal of tyrosine residue hIAPP. A detection limit 1×10-6 M for hIAPP has been obtained. kinetic study aggregation process carried out according relationship between anodic peak current square voltammograms and incubation period. The results show that nucleation starts first hour then, during next two hours, may occur rapidly. can therefore be monitored with a label-free...
Tremendous scientific research has been conducted on chronic kidney disease-mineral and bone disorder (CKD-MBD), while only a few bibliometric analyses have in this field. In study, we aim to identify 100 top-cited articles CKD-MBD analyze their main characteristics quantitatively.
The title compound, C25H21ClN2O2, was synthesized by the reaction of 5-methoxy-1H-indole and 4-chlorobenzaldehyde in ethanol using CuBr2 as a catalyst under microwave irradiation. In crystal structure, there is an intermolecular N—H⋯O hydrogen bond two C—H⋯π contacts.
The title compound, C25H21BrN2O2, was synthesized by the reaction of 5-methoxy-1H-indole and 4-bromobenzaldehyde in ethanol, using CuBr2 as a catalyst under microwave irradiation. In crystal structure, there is an intermolecular N—H⋯O hydrogen bond two C—H⋯π contacts.