A5102791260- Breast Cancer Treatment Studies
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Endometrial and Cervical Cancer Treatments
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Cancer survivorship and care
- Cancer Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Breast Implant and Reconstruction
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- Brain Tumor Detection and Classification
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Protease and Inhibitor Mechanisms
- Meningioma and schwannoma management
- Chemotherapy-induced cardiotoxicity and mitigation
Ruijin Hospital
2017-2025
Shanghai Jiao Tong University
2017-2025
Renji Hospital
2025
Shanghai Medical College of Fudan University
2020
Fudan University Shanghai Cancer Center
2020
Institut Gustave Roussy
2016
Abstract Background Recent studies have highlighted bidirectional signalling between tumours and neurons; however, the interactions neurons in response to radio-/chemotherapy remain obscure, which hampers tumour treatment. Methods Glioblastoma organoids (GBOs) primary neuron coculture, targeted metabonomics, RNA pulldown, mass spectrum, co-immunoprecipitation, RNA-sequencing, transcript/protein validations multi-electrode arrays were performed analyse neuron-tumour interaction therapy. In...
The outbreak of COVID-19 pandemic has greatly impacted on radiotherapy (RT) strategy for breast cancer patients, which might lead to increased distressing psychological symptoms. We performed a multi-center cross-section survey investigate prevalence fear recurrence (FCR) and predictors FCR in patients referred RT during pandemic.
ObjectivesThis study aimed to explore the spatial distribution of brain metastases (BMs) from breast cancer (BC) and identify high-risk sub-structures in BMs that are involved at first diagnosis.MethodsMagnetic resonance imaging (MRI) scans were retrospectively reviewed our centre. The was divided into eight regions according its anatomy function, volume each region calculated. identification calculation metastatic lesions accomplished using an automatically segmented 3D BUC-Net model....
Hippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less-impaired cognitive function than conventional WBRT. The study aims to assess radiological distribution metastases (BMs) with relation hippocampus and peri-hippocampus region as defined by RTOG 0933 for better understanding margin definition HA-WBRT treatment planning.Consecutive patients diagnosis BM from enhanced MRI between March 2011 July 2016 were analysed. pre-treatment T1 weighted, T2 flair,...
Short course regimen has become the major trend in field of adjuvant radiotherapy for patients with breast cancer. Hypofractionated (HF-RT) 40-42.5 Gy 15-16 fractions been established as a preferred option whole irradiation. However, few evidences hypofractionated regional nodal irradiation (RNI), especially involving internal mammary nodes (IMNs), could be available during era intensity-modulated radiation therapy (IMRT). Against this background, we design trial to explore hypothesis that...
Abstract Optimal cardiac dose constraints in breast cancer (BC) patients undergoing postoperative intensity‐modulated radiation therapy (IMRT) are unclear, although as low possible is recommended. This trial proposes serial constraint to optimize safety. Postoperative BC eligible for anthracycline/taxanes‐based chemotherapy or HER2‐targeted were randomized safety arm with prespecified mean heart (MHD) (≤6 Gy), V30 (≤20%), and V10 (≤50%) constraints, a control in‐house protocol (mainly MHD ≤8...
In this study, we attempted to assess the efficacy of upfront brain radiotherapy (RT) in breast cancer (BC) patients with metastases (BM). Medical records 111 consecutive BC treated WBRT or SRS between August 2009 and November 2017 single center were retrospectively reviewed. Eighty received RT after BM diagnosis 31 had delayed RT. The median age at was 54 years (22-77), KPS 80 (50-90). molecular subtypes Luminal A, B, triple-negative HER2 overexpression 16, 47, 27, 19, respectively, 2...
Purpose: Radiation-induced temporal lobe necrosis (TLN) was once regarded as a progressive and irreversible disease in the era of two-dimensional radiotherapy. However, intensity-modulated radiotherapy (IMRT), long-term development process TLN remains unknown. We performed prospective study to evaluate dynamic changes cognitive function patients with after definitive IMRT for nasopharyngeal carcinoma (NPC). Methods: The enrollment criteria were follows: (1) must have had confirmed NPC...
5538 Background: To assess the safety and efficacy of toripalimab combined with chemoradiotherapy for locally advanced cervical squamous cell carcinoma (Chinese Clinical Trial Registry number, ChiCTR2000032879). Methods: Twenty-two cancer patients, regardless programmed death ligand-1 status, received treatment concurrent chemoradiotherapy. Concurrent chemoradiotherapy(CCRT) includes cisplatin (40 mg/m2, once a week 5 weeks), radiotherapy (external irradiation 45-50.4Gy/25-28Fx, fractions...
Abstract: Breast cancer is one of the most common malignancies among women worldwide. According to International Agency for Research on Cancer, breast affected more Chinese than any other in 2020. The brain an increasingly metastatic sites cancer. Although risk developing metastases (BMs) lower lung and melanoma, due its high prevalence, it second cause BM solid tumors, being only incidence metastasis (BCBM) differs by molecular subtype. Half patients with advanced human epidermal growth...
To investigate the early predictive value of dynamic magnetic resonance imaging (MRI)-based radiomics for progression and prognosis in locally advanced cervical cancer (LACC) patients treated with concurrent chemoradiotherapy (CCRT). A total 111 LACC (training set: 88; test 23) were retrospectively enrolled. Dynamic MR images acquired at baseline (MRIpre), before brachytherapy delivery (MRImid) each follow-up visit. Clinical characteristics, 2-year progression-free survival (PFS), overall...
Objective Whole brain radiotherapy (WBRT) remains the primary treatment for patients with multiple metastases (BM). Hippocampal avoidance WBRT (HA-WBRT) offers feasibility of less cognitive function impairment than conventional WBRT.WBRT yields better control rate intracranial distant progression stereotatic body (SBRT). This study aims to understand distribution characteristics BM within cranial structures by analyzing imaging features and define safe margin during...
11571 Background: Tumor invasion patterns are known to be associated with HNSCC pts outcome. Radiomics is a rapidly-emerging field involving the extraction of quantitative imaging features from standard medical images, and their integration clinical traits. Whether advanced 3D tumor shape parameters reflect invasiveness outcome in remains unknown. Methods: Two cohorts were analyzed: 120 LA (Gustave Roussy) 164 (TCGA HNSCC). Semi-automatic contours baseline contrast-enhanced CT scans...
To determine the relationship between time to radiotherapy (TTR) and survival outcomes in breast cancer (BC) patients treated with neoadjuvant treatments (NATs). Continuous non-metastatic BC receiving NAT adjuvant (RT) from 2009 2016 were retrospectively reviewed. A multivariable Cox model restricted cubic splines (RCSs) was used panoramic TTR outcomes. Multivariable analysis control for confounding factors groups of TTR. total 315 included. The RCS modeling demonstrated a non-linear lowest...
Purpose. A survival benefit of breast-conserving therapy (BCT) over mastectomy has been shown in recent studies. This study aimed to explore differences recurrence patterns between BCT and clarify the contribution radiotherapy (RT) BCT. Methods. Consecutive patients with pT1-2/pN0-1/M0 breast cancer 2009 2015 our institution were retrospectively reviewed compared matched cohorts using 1 : propensity score matching (PSM). Results. total 2370 enrolled a median follow-up 75 (3–148) months. In...