A5061126882- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Cancer survivorship and care
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- 14-3-3 protein interactions
- Metabolism, Diabetes, and Cancer
- Advances in Oncology and Radiotherapy
- Ubiquitin and proteasome pathways
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Seed Germination and Physiology
- Phytochemicals and Antioxidant Activities
- Glycogen Storage Diseases and Myoclonus
- Bone health and osteoporosis research
- Meta-analysis and systematic reviews
- COVID-19 and healthcare impacts
- Lipid metabolism and biosynthesis
- Body Composition Measurement Techniques
- Erythrocyte Function and Pathophysiology
- Plant tissue culture and regeneration
- Endoplasmic Reticulum Stress and Disease
Fudan University
2020-2025
Hangzhou First People's Hospital
2022-2025
Westlake University
2024-2025
Shenyang Agricultural University
2024
Sichuan University
2024
Zhejiang University
2022-2023
Xian Yang Central Hospital
2016-2023
Yueyang Second People's Hospital
2021
Xiamen University
2017
Eli Lilly (United States)
2007
Lysine methyltransferase KMT5C catalyzes deposition of trimethylation on histone H4 lysine 20 (H4K20me3), an epigenetic marker usually associated with gene repression and maintenance heterochromatin. is widely expressed in a variety tissues, however, its functional role liver has not been explored. Here, we show Kmt5c fasting- glucagon-induced which regulates hepatic gluconeogenesis. Loss hepatocytes results downregulated gluconeogenic expression compromised glucose output during fasting....
Abstract It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether contributes to metabolic reprogramming. Here we find can interact with and phosphorylate hexokinases HK1 HK2, the rate-limiting enzymes glycolysis. Tyrosine phosphorylation dramatically increases their catalytic activity thus enhances Mechanistically, of at Tyr732 robustly decreases its K m V max by disrupting dimer formation. Mutation site either or HK2 remarkably abrogates...
Using data from a randomized placebo-controlled trial of 10,101 postmenopausal women not selected on the basis osteoporosis, we examined whether effect raloxifene treatment fractures was consistent across categories fracture risk. Treatment with for 5 yr reduced risk clinical vertebral fractures, but nonvertebral irrespective presence or absence factors fracture.In The Raloxifene Use Heart (RUTH) trial, assigned to had lower fractures. However, it is uncertain in this population low BMD...
Brown and beige fat are specialized for energy expenditure by dissipating from glucose fatty acid oxidation as heat. While metabolism have been extensively studied in thermogenic adipose tissues, the involvement of amino acids regulating adaptive thermogenesis remains little studied. Here, we report that asparagine supplementation brown adipocytes drastically upregulated transcriptional program lipogenic gene expression, so asparagine-fed mice showed better cold tolerance. In with...
Mitochondria are the pivot organelles to control metabolism and energy homeostasis. The capacity of mitochondrial metabolic adaptions cold stress is essential for adipocyte thermogenesis. How brown adipocytes keep fitness upon a challenge cold-induced oxidative has not been well characterized. This manuscript shows that IFI27 plays an important role in cristae morphogenesis, keeping intact succinate dehydrogenase (SDH) function active fatty acid oxidation sustain thermogenesis adipocytes....
Two hallmarks of cancer cells are their resistance to apoptosis and ability thrive despite reduced levels vital serum components. c-jun N-terminal kinase (JNK) activation is crucial for triggered by starvation (SS), isocitrate dehydrogenase 1 (IDH1) mutations tumorigenic, in part, because they produce the abnormal metabolite 2-hydroxyglutarate (2-HG). However, it unknown whether 2-HG-induced tumorigenesis partially due JNK inhibition thus defective SS-induced apoptosis. We show here, using...
The outbreak of COVID-19 pandemic has greatly impacted on radiotherapy (RT) strategy for breast cancer patients, which might lead to increased distressing psychological symptoms. We performed a multi-center cross-section survey investigate prevalence fear recurrence (FCR) and predictors FCR in patients referred RT during pandemic.
Significance The thermogenic function of adipocytes relies on the activation program that is coordinately modulated by an array unique transcriptional and epigenetic regulators. Histone methylations represent essential mode regulation in establishment tissue-specific gene expression. However, role H4K20 methylation not completely elucidated. Our paper revealed Kmt5c involved regulating adipose tissues. Adipocyte-specific KO mice demonstrate decreased expression genes are prone to...
Abstract Histone deacetylases (HDACs) are widely involved in many biological processes, as well control of brown and beige adipose physiology, but the precise molecular mechanisms by which HDACs assembled into transcriptional machinery to fine‐tune thermogenic program remain ill‐defined. PWWP domain containing 2b (PWWP2B), is identified a component nucleosome remodeling deacetylation complex (NuRD), interacts stabilizes HDAC1/2 at gene promoters suppress their expression. Ablation Pwwp2b...
Y-box binding protein 2 (YBX2) is an essential modulator of brown adipose tissue activation, yet the regulation on its own expression and involved mechanism remains largely unknown. Herein, we report YBX2 level, but not mRNA induced in response to acute β-adrenergic signaling. In this context, a dual substrate for both AMPK Akt2. The phosphorylation at Thr115 by or Ser137 Akt2 facilitates accumulation adipocytes decreasing ubiquitination-mediated degradation. Beyond stabilizing PGC1α mRNA,...
<sec> <title>UNSTRUCTURED</title> With the coming of aging society, prevalence sarcopenia increases rapidly. Sarcopenia is a progressive, generalized reduction in muscle mass, strength, and physiological function accompany it risk factor for many metabolic diseases. Previous studies found that immune cells take part whole process regeneration. Autoimmune diseases are series related characterized by dysregulation system, which could lead to inflammation multi-tissue damage. Meanwhile,...
Objectives This retrospective study was conducted to assess the efficacy and safety of high intensity focused ultrasound (HIFU) in combination with chemotherapy compared alone treating patients unresectable locally advanced pancreatic cancer (LAPC). Methods The data LAPC who received or without HIFU ablation were retrieved retrospectively. overall survival (OS), objective response rate (ORR), antigen 19‐9 rate, between these two groups before after propensity score matching (PSM). Results...
Objective To study the methods of weaning from invasive mechanical ventilation on chronic obstructive pulmonary disease (COPD) patients with repiratory failure.Methods 108 COPD respiratory failure were ventilated by machine,and data collected to analyze.Results 106 cases weaned off and extubated.The success rate was 98％.Conclusions Effective has a high rate. Key words: Chronic disease; Mechanical ventilation; Respiratory
目的 观察热疗联合同步放化疗治疗中晚期子宫颈癌的近期临床效果。 方法 选取2013年1月到2015年1月收治的ⅡB~ⅢB期子宫颈癌患者156例，按照治疗方法分为两组，对照组患者给予同步放化疗治疗，观察组患者在对照组治疗方案的基础上给予热疗，每组78例。回顾性分析比较两组患者的近期效果。 结果 观察组和对照组患者治疗有效率分别为92.3 %（72/78）和88.5 %（69/78），差异有统计学意义（P 0.05）。 结论 中晚期子宫颈癌患者给予热疗联合同步放化疗处理，在不增加不良反应发生率的情况下，可提高近期疗效。
Objective To evaluate the application of nasal endotracheal intubation guided by ultrathin fibreoptic bronchoscope in awake patients with respiratory failure.Methods 105 failure were ventilated machine through bronchoscope.102 bronchoscope.The successful rate and complications compared between two groups.Results The group was higher than that control (100.0％ vs 73.5％,x2=31.96,P ＜0.05).Nasal bleeding lower (5.7％ 20.0％,x2=8.66,P ＜0.05).Conclusions Application plays an important role treatment...
the Pdgrfa + / Thy1 -(LP) cells sorted from E14.5 embryos to determine adipocyte fate.Adipocytes, derived multipotent mesenchymal stem cells, goes through two phases of adipogenesis.The first phase, known as determination, converts pluripotent cell into lineage which lost potential differentiate other type.In second preadipocytes give rise mature adipocytes, is called terminal differentiation [17].However, role RGCC in stage brown especially regulation thermogenesis, had not yet been...
Y-box binding protein 2 (YBX2) is an essential modulator of brown adipose tissue (BAT) activation, yet the regulation on its own expression and involved mechanism remains unclear. Herein, we found YBX2 level, but not mRNA was induced upon acute β-adrenergic signaling, which indicates can be post-transcriptionally modulated. a dual substrate for both AMPK Akt2. The phosphorylation at Thr115 by or Ser137 Akt2 facilitated accumulating in adipocytes decreasing ubiquitination-mediated...
Abstract Background The outbreak of COVID-19 pandemic in China has greatly impacted the radiotherapy (RT) strategy for breast cancer (BC) patients, which might lead to an increased distressing psychological symptom. Thus, we perform a multi-center cross-section survey aiming investigate prevalence fears recurrence (FCR) and explore predictors FCR BC patients referred RT during pandemic. Methods: 542 who between 24th Jan 30th April 2020 were consecutively enrolled from 14 hospitals around...