A5000311825- Cancer, Hypoxia, and Metabolism
- Boron Compounds in Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Diet and metabolism studies
- Lignin and Wood Chemistry
- Covalent Organic Framework Applications
- Luminescence and Fluorescent Materials
- Diet, Metabolism, and Disease
- Biofuel production and bioconversion
- Organoboron and organosilicon chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Pharmacological Effects and Toxicity Studies
- Catalytic C–H Functionalization Methods
- Adipose Tissue and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Metabolism and Genetic Disorders
- Supramolecular Chemistry and Complexes
- Enzyme-mediated dye degradation
- Fungal Infections and Studies
- Cancer Research and Treatments
- Biochemical and biochemical processes
- Supercapacitor Materials and Fabrication
Xiamen University
2017-2024
Shanghai Institute of Organic Chemistry
2021-2024
University of Chinese Academy of Sciences
2024
Changzhou University
2014-2024
First Affiliated Hospital of Xiamen University
2023
Diabetes Australia
2023
Chinese Academy of Sciences
2021-2022
Texas A&M University
2016-2021
Texas A&M University System
2016-2021
College Station Medical Center
2019
Biological lignin valorization has emerged as a major solution for sustainable and cost-effective biorefineries. However, current biorefineries yield with inadequate fractionation bioconversion, yet substantial changes of these biorefinery designs to focus on could jeopardize carbohydrate efficiency increase capital costs. We resolve the dilemma by designing 'plug-in processes lignin' integration leading pretreatment technologies. Substantial improvement bioconversion synergistic enhancement...
Metabolic reprogramming, especially Warburg effect, is a key event in tumor initiation and progression. ZEB1 plays vital role metastasis of various cancers. We previously found that was excessively expressed hepatocellular carcinoma (HCC) its high expression closely correlated with recurrence HCC. want to know whether glycolytic enzymes are regulated by contribute carcinogenesis Methods: To explore could enhance glycolysis HCC, we knocked down short hairpin RNA (shRNA) MHCC-97H HCC-LM3 cells...
Abstract 1,2,3‐Trisubstituted closo ‐dodecaborates with B−O, B−N, and B−C bonds as well a fused borane oxazole ring have been synthesized by rhodium‐catalyzed direct cage B−H alkenylation annulation of ureido boranes in the first reported example regioselective bond functionalization [B 12 H ] 2− transition‐metal catalysis. This reaction proceeded at room temperature under ambient conditions exhibited excellent selectivity for efficient monoalkenylation good functional‐group tolerance. The...
Abstract It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear whether contributes to metabolic reprogramming. Here we find can interact with and phosphorylate hexokinases HK1 HK2, the rate-limiting enzymes glycolysis. Tyrosine phosphorylation dramatically increases their catalytic activity thus enhances Mechanistically, of at Tyr732 robustly decreases its K m V max by disrupting dimer formation. Mutation site either or HK2 remarkably abrogates...
Lignin valorization has recently been considered to be an essential process for sustainable and cost-effective biorefineries. represents a potential new feedstock value-added products. Oleaginous bacteria such as Rhodococcus opacus can produce intracellular lipids from biodegradation of aromatic substrates. These used biofuel production, which potentially replace petroleum-derived chemicals. However, the low reactivity lignin produced pretreatment underdeveloped fermentation technology...
A series of cage penta-arylated carboranes have been synthesized by palladium-catalyzed intermolecular coupling the C-carboxylic acid monocarba- closo-dodecaborate anion [CB11H12]- with iodoarenes direct B-H bond functionalization. These transformations set a record in terms one-pot directing group-mediated activation inert bonds single molecule. The methodology is characterized high yields, good functional group tolerance, and complete regioselectivity. COOH can be easily removed during or...
Lignin depolymerization mainly involves redox reactions relying on the effective electron transfer. Even though mediators were previously used for delignification of paper pulp, no study has established a bioprocess to fragment and solubilize lignin with an laccase–mediator system, in particular, subsequent microbial bioconversion. Efficient was achieved by screening proper laccase attain nearly 6-fold increase kraft solubility compared control without treatment. Chemical analysis suggested...
Cooperative valorization of lignin and residual sugar has the potential to improve sustainability profitability biorefineries.
Bacterial protein secretion represents a significant challenge in biotechnology, which is essential for the cost-effective production of therapeutics, enzymes, and other functional proteins. Here, it demonstrated that proteomics-guided engineering transcription, translation, secretion, folding ligninolytic laccase balances process, minimizes toxicity, enables efficient heterologous with total yield 13.7 g L
Heparins are widely used anticoagulants for surgical procedures and extracorporeal therapies. However, all of them have bleeding risks. Protamine sulfate, the only clinically approved antidote unfractionated heparin (UFH), has adverse effects. Moreover, protamine can partially neutralize low-molecular-weight heparins (LMWHs) is not effective fondaparinux. Here, an inclusion-sequestration strategy efficient neutralization by cationic porous supramolecular organic frameworks (SOFs) polymers...
Abstract Developing dynamic color‐tunable ultra‐long room temperature phosphorescence (URTP) polymers with afterglow of over 1 s, photo‐chromism, and multi‐stimuli response for practical anti‐counterfeiting information security applications is attractive but very challenging. Herein, by doping multicolor pyridinium bromide L block or viologen‐based photo‐chromic V into polyvinyl alcohol matrixes, the water‐stimuli‐responsive URTP polymer films up to 8 s reversible photochromic have been...
The development of a reversal agent that can rapidly reverse clinically used nondepolarizing neuromuscular blocking agents (NMBAs) has long been challenge. Here, we report the synthesis series highly water-soluble acyclic cucurbit[
Reprogramming of glucose metabolism is a key event in tumorigenesis and progression. Here, we show that active c-Src stimulates glycolysis by phosphorylating (Tyr194) activating PFKFB3, enzyme boosts producing fructose-2,6-bisphosphate PFK1. Increased intermediates replenish non-oxidative pentose phosphate pathway (PPP) serine for biosynthesis cancer cells. PFKFB3 knockout (KO) cells their counterpart reconstituted with PFKFB3-Y194F comparably impaired abilities proliferation, migration,...
Abstract Porous organic polymers (POPs) have become an emerging class of advanced porous materials owing to their structural diversity and tailored functions in solid state media. Creating water‐soluble related water‐dispersible POPs is still very challenging the research area materials. Their porosity‐based with diverse topological architectures aqueous media offer promising platforms bio‐related fields. This review highlights recent progress on water soluble or dispersible for biomedical...
Increased fatty acid synthesis benefits glioblastoma malignancy. However, the coordinated regulation of cytosolic acetyl-CoA production, exclusive substrate for synthesis, remains unclear. Here, we show that proto-oncogene tyrosine kinase c-SRC is activated in and remodels production synthesis. Firstly, acetate an important glioblastoma. phosphorylates synthetase ACSS2 at Tyr530 Tyr562 to stimulate conversion cytosol. Secondly, inhibits citrate-derived by phosphorylating ATP-citrate lyase...
Abstract An iridium‐catalyzed alkenylation/annulation sequence between monocarba‐ closo ‐dodecaborate carboxylic acids and diarylacetylenes is reported. Regioselective activation of the B2 position, followed by B−C bond formation ring closure, affords 3D bora‐analogues isocoumarins. The reaction tolerates a variety functional groups on aromatic rings can be extended to B12‐substituted derivatives. Furthermore, subsequent alkenylation B4 vertex has been achieved in high yields.
Cryptococcus neoformans (Cn) is a deadly fungal pathogen whose intracellular lifestyle important for virulence. Host mechanisms controlling phagocytosis and replication remain obscure. Here, we perform global phosphoproteomic analysis of the host response to infection. Our reveals numerous diverse proteins that are differentially phosphorylated following ingestion by macrophages, thereby indicating reprogramming kinase signaling. Notably, activates autophagy initiation complex (AIC) upstream...
Broad-spectrum agents for the reversal of residual curarization induced by neuromuscular blocking are great significance. Here, we report a highly water-soluble cucurbit[8]uril (CB[8]) derivative as broad-spectrum block agent both benzylisquinolinium and aminosteroid supramolecular sequestration strategy. The UV/Vis competition titration assays suggest high binding affinity CB[8] toward benzylisquinolinium-type cisatracurium besylate aminosteroid-type rocuronium, vecuronium, pancuronium, at...