A5103274413- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Legume Nitrogen Fixing Symbiosis
- Virus-based gene therapy research
- Bacterial Genetics and Biotechnology
- Bacteriophages and microbial interactions
- Neonatal Health and Biochemistry
- Fibroblast Growth Factor Research
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
Xiamen University
2020-2023
Xiaochang People's Hospital
2018
Reprogramming of glucose metabolism is a key event in tumorigenesis and progression. Here, we show that active c-Src stimulates glycolysis by phosphorylating (Tyr194) activating PFKFB3, enzyme boosts producing fructose-2,6-bisphosphate PFK1. Increased intermediates replenish non-oxidative pentose phosphate pathway (PPP) serine for biosynthesis cancer cells. PFKFB3 knockout (KO) cells their counterpart reconstituted with PFKFB3-Y194F comparably impaired abilities proliferation, migration,...
Abstract Resistance to immunotherapy in colorectal cancer (CRC) is associated with obstruction of FAS (Apo‐1 or CD95)‐dependent apoptosis, a hallmark cancer. Here it demonstrated that the upregulation pirin (PIR) protein colon cancers promotes tumorigenesis. Knockout inhibition PIR dramatically increases expression, FAS‐dependent apoptosis and attenuates tumor formation mice. Specifically, NFκB2 direct transcriptional activator robustly suppressed by dual mechanisms. One disruption complex...
Mutants of Bacillus subtilis which carried suppressor mutations for catabolite-resistance gene crsA47 were isolated from methylmethanesulfonate-treated cultures GLU-47 (crsA47). The mutation, sca19, suppressed resistance mutant to glucose and other inhibitors sporulation. Moreover, the mutation could restore rate growth level IMP dehydrogenase alkaline phosphatase wild-type level. sca19 was also able suppress catabolite crs mutants. map position sea19 indicated that this an intergenic It...