A5100363145- Microplastics and Plastic Pollution
- Heavy metals in environment
- Pharmaceutical and Antibiotic Environmental Impacts
- Per- and polyfluoroalkyl substances research
- Cell death mechanisms and regulation
- Microbial Community Ecology and Physiology
- Recycling and Waste Management Techniques
- Environmental Toxicology and Ecotoxicology
- Soil and Water Nutrient Dynamics
- Methane Hydrates and Related Phenomena
- Toxic Organic Pollutants Impact
- Plant Micronutrient Interactions and Effects
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Wastewater Treatment and Nitrogen Removal
- Plant Stress Responses and Tolerance
- Mitochondrial Function and Pathology
- Pesticide and Herbicide Environmental Studies
- Coastal wetland ecosystem dynamics
- Luminescence and Fluorescent Materials
- Ecology and Vegetation Dynamics Studies
- Plasmonic and Surface Plasmon Research
- Membrane Separation Technologies
- Vector-borne infectious diseases
- Inflammasome and immune disorders
Huaqiao University
2023-2024
State Forestry and Grassland Administration
2022-2024
Chinese Academy of Sciences
2011-2024
Beijing Forestry University
2024
Institute of Zoology
2022-2024
University of Chinese Academy of Sciences
2024
Xiamen University
2014-2024
Institute of Applied Ecology
2009-2024
Nanjing Agricultural University
2024
China University of Petroleum, East China
2024
Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting 3 (RIP3) in tumor necrosis factor-α (TNF)-induced (also called necroptosis). However, how MLKL functions mediate necroptosis is unknown. By reconstitution MLKL-knockout cells, we showed that the N-terminus required for its necroptosis. The oligomerization TNF-treated cells essential necroptosis, as artificially forcing together by using hormone-binding domain (HBD*) triggers Notably,...
Necroptosis and pyroptosis are two forms of programmed cell death with a common feature plasma membrane rupture. Here we studied the morphology mechanism in comparison necroptosis. Different from necroptosis, undergoes blebbing produces apoptotic body-like protrusions (termed pyroptotic bodies) prior to The rupture necroptosis is explosion-like, whereas it leads flattening cells. It known that execution mediated by mixed lineage kinase domain-like (MLKL) oligomers membrane, gasdermin-D...
Abstract Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), proinflammatory cytokine, prototypic trigger necroptosis. It known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and kinase activity receptor interacting protein 1 (RIP1) required for TNF-induced However, how ROS function what RIP1 phosphorylates to necroptosis are largely unknown. Here we show three crucial cysteines sensing...
Abstract Reactive oxygen species (ROS) production in phagocytes is a major defense mechanism against pathogens. However, the cellular self-protective such potential damage from oxidative stress remains unclear. Here we show that kinases Mst1 and Mst2 (Mst1/2) sense ROS maintain redox balance by modulating stability of antioxidant transcription factor Nrf2. Site-specific release recruits Mst1/2 cytosol to phagosomal or mitochondrial membrane, with subsequently activating phosphorylate kelch...
Oligomerization of the mixed-lineage kinase domain-like protein (MLKL) is essential for its cation channel function in necroptosis. Here we show that MLKL an octamer comprising two previously identified tetramers most likely their side-by-side position. Intermolecule disulfide bonds are present tetramer but not required assembly and forms oligomers necrosome then released from before or during membrane translocation. We mutants could oligomerize into octamers, although they formed a...
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how transmits lack occupancy by FBP remains unclear. Here, we show that FBP-unoccupied interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease at contact sites between ER lysosome renders inhibited TRPV accessible bind v-ATPase then...
There remains a significant gap in our quantitative understanding of crosstalk between apoptosis and necroptosis pathways. By employing the SWATH-MS technique, we quantified absolute amounts up to thousands proteins dynamic assembling/de-assembling TNF signaling complexes. Combining SWATH-MS-based network modeling experimental validation, found that when RIP1 level is below ~1000 molecules/cell (mpc), cell solely undergoes TRADD-dependent apoptosis. When above mpc, pro-caspase-8 RIP3 are...
We numerically demonstrate a broadband terahertz (THz) absorber that is based on hybrid-patterned graphene metasurface with excellent properties of polarization insensitivity, wide-angle, and active tunability. Our design made up single-layer periodically arranged hybrid square/disk/loop patterns multilayer structure. find absorption 90% absorbance the fractional bandwidth 84.5% from 1.38 THz to 3.4 can be achieved. Because axisymmetric configuration, demonstrates absolute independence for...
Ookinete gliding motility is essential for penetration of the mosquito midgut wall and transmission malaria parasites. Cyclic guanosine monophosphate (cGMP) signaling has been implicated in ookinete gliding. However, upstream mechanism how parasites activate cGMP thus initiate remains unknown. Using real-time imaging to visualize Plasmodium yoelii guanylate cyclase β (GCβ), we show that cytoplasmic GCβ translocates polarizes parasite plasma membrane at "ookinete extrados site" (OES) during...
In this study, a Co-30Ni-10Al-6Ta-10Cr alloy was designed based on CALPHAD (Calculation of Phase Diagrams) method targeting high γ′ phase fraction and solvus, optimal thermal processing window. Experimental results concurred with the calculations validated Cr as γ phase-forming element in Co-Ni-Al-Ta-based alloys. The incorporation helps mitigate lattice misfit, coarsening rate, density, while enhancing microstructural stability. A certain amount led to development superalloy both mechanical...
The harsh environment on the Qinghai-Tibetan Plateau gives Tibetan hulless barley (Hordeum vulgare var. nudum) great ability to resist adversities such as drought, salinity, and low temperature, makes it a good subject for analysis of drought tolerance mechanism. To elucidate specific gene networks pathways that contribute its tolerance, identifying new candidate genes breeding purposes, we performed transcriptomic using two accessions barley, namely Z772 (drought-tolerant) Z013...
Non-wood forest products (NWFPs) derived from understory plants are attracting attention about sustainable forestry development. Geographical distribution and climate correlates of bioactive compounds important to the regional management for natural reserves medical in forests. In this study, we collected Eleutherococcus senticosus individuals 27 plots map special concentrations eleutheroside B, E, isofraxidin forests Northeast China. Compound both aerial underground organs were further...
A salt-tolerant denitrifying bacterium F1 was isolated in this study, which has high nitrite (NO2--N) and nitrate (NO3--N) removal abilities. The salt tolerance capacity of strain further verified the effects initial pH, NaNO2 concentration inoculation size on denitrification under saline conditions were evaluated. Strain identified as Pannonibacter phragmitetus named F1. This can tolerate NaCl concentrations up to 70 g/L, its most efficient observed at 0-10 g/L. Under non-saline condition,...