A5063356611- Cellular Mechanics and Interactions
- Metabolism, Diabetes, and Cancer
- Molecular Biology Techniques and Applications
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Fungal and yeast genetics research
Fudan University
2023-2025
Lysine methyltransferase KMT5C catalyzes deposition of trimethylation on histone H4 lysine 20 (H4K20me3), an epigenetic marker usually associated with gene repression and maintenance heterochromatin. is widely expressed in a variety tissues, however, its functional role liver has not been explored. Here, we show Kmt5c fasting- glucagon-induced which regulates hepatic gluconeogenesis. Loss hepatocytes results downregulated gluconeogenic expression compromised glucose output during fasting....
Abstract Septins as GTPases in the cytoskeleton, are linked to a broad spectrum of cellular functions, including cell migration and progression hepatocellular carcinoma (HCC). However, roles SEPT11, new member septin, have been hardly understood HCC. In study, clinical significance biological function SEPT11 HCC was explored. screened out by combining ATAC-seq with mRNA-seq. Role further investigated using overexpression, shRNA CRISPR/Cas9-mediated SEPT11-knockout cells or vivo models. We...