A5083932079- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- BRCA gene mutations in cancer
- Hematopoietic Stem Cell Transplantation
- Traditional Chinese Medicine Analysis
- Protein Degradation and Inhibitors
- Ginseng Biological Effects and Applications
- Mesenchymal stem cell research
- Natural product bioactivities and synthesis
- PARP inhibition in cancer therapy
- Immune cells in cancer
- Autoimmune and Inflammatory Disorders Research
- Genomics, phytochemicals, and oxidative stress
- Thyroid Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Wnt/β-catenin signaling in development and cancer
- Fibroblast Growth Factor Research
- Chronic Lymphocytic Leukemia Research
Renji Hospital
2025
Shanghai Jiao Tong University
2018-2025
Ruijin Hospital
2023-2025
Henan Agricultural University
2024
Tongji University
2009-2023
Shanghai Tenth People's Hospital
2019-2023
North China University of Science and Technology
2023
North China University of Science and Technology Affiliated Hospital
2021-2023
Guiyang College of Traditional Chinese Medicine
2023
Guizhou University
2020-2023
Purpose: ras oncogenic activation has long been demonstrated in thyroid carcinomas of follicular cell derivation, but no consistent relationship shown between mutations and clinicopathologic features. Materials Methods: We analyzed H-, K-, N-ras by polymerase chain reaction–single-strand conformational polymorphism followed DNA sequencing 125 carcinoma specimens from 107 patients, to include tumors covering the entire spectrum tumor differentiation. Results: Mutations were identified four...
Acute exposure to high-dose radiation during head and neck tumors radiotherapy can result in radiation-induced brain injury (RIBI), characterized by neurocognitive deficits, dementia, epilepsy. Asparagine endopeptidase (AEP), a cysteine proteinase, is effective preventing neurodegenerative diseases RIBI. However, the limited permeability of selective AEP inhibitor (AEPI) delivery reduces its effectiveness This study constructed nose-to-brain platform for AEPI encapsulating it liposomes that...
An unexpected observation among the COVID-19 pandemic is that smokers constituted only 1.4%–18.5% of hospitalized adults, calling for an urgent investigation to determine role smoking in SARS-CoV-2 infection. Here, we show cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase ACE2 mRNA but trigger protein catabolism. BaP induces aryl hydrocarbon receptor (AhR)-dependent upregulation ubiquitin E3 ligase Skp2 ubiquitination. lung tissues non-smokers higher than smokers,...
Depression is one of the most common mental disorders characterized mainly by low mood and loss interest or pleasure. About a third patients with depression do not respond to classic antidepressant treatments. Recent evidence suggests that Mrp8/14 (myeloid-related protein 8/14) plays crucial role in cognitive dysfunction neuroinflammatory diseases, yet its regulation remains largely uninvestigated. In present work, we explored potential progression depression. After 4 weeks chronic...
The interleukin-23 (IL-23)/IL-17 immune axis has been linked to the pathology of psoriasis, but how this contributes skin inflammation in disease remains unclear. We measured inflammatory cytokines associated with IL-23/IL-17 serum patients psoriasis using enzyme-linked immunosorbent assays. Psoriasis was induced male C57BL/6J mice imiquimod (IMQ) cream, and animals received intraperitoneal injections recombinant mouse anti-IL-23A or anti-IL-17A antibodies for 7 days. potential effects on...
An increasing number of patients are being killed by coronavirus disease 2019 (COVID-19), however, risk factors for the fatality COVID-19 remain unclear. A total 21,392 cases were recruited in Hubei Province China between December and February 2020, followed up until March 18, 2020. We adopted Cox regression models to investigate case predicted death probability under specific combinations key predictors. Among patients, 1,020 (4.77%) died COVID-19. Multivariable analyses showed that...
To observe the therapeutic effect of Carvacrol on oral squamous cell carcinoma (OSCC) and dissect underlying molecular mechanisms.Keap1/Nrf2, NALP3, Vimentin, E-cadherin expression was detected in OSCC normal mucosa (NOM) tissues using immunofluorescence or western blot. When treated with tert-butylhydroquinone (TBHQ) that activates Nrf2, Keap1/Nrf2/HO-1, epithelial-mesenchymal transition- (EMT-) related proteins, NALP3 examined cells. Nrf2 silenced by treatment sh-Nrf2 ML385. After...
Background Cannabinoid (CB) receptors are involved in the regulation of gastrointestinal (GI) motility under physiological and pathophysiological conditions. We aimed to characterize possible influence CB1 CB2 on impairment a model septic ileus. Methods Lipopolysaccharide (LPS) injections were used mimic features Spontaneous jejunal myoelectrical activity was measured rats vivo, upper GI transit vivo by gavaging charcoal marker into stomach mice, absence or presence LPS, receptor agonists...
Abstract Allogeneic haematopoietic stem cell transplantation (allo‐HSCT) is the only curative method in treating haematologic malignant diseases. Graft‐versus‐host disease (GVHD) a common complication post–allo‐HSCT, which can be life‐threatening. Mesenchymal cells (MSCs) as an adult with immunoregulatory function have demonstrated efficacy steroid resistant acute GVHD (aGVHD). However, outcome of aGVHD treated MSCs clinical trials varied and its underlying mechanism still unclear. TGF‐β1...
Qi-Jing-Sheng-Bai granule (QJSB) is a new developed traditional Chinese medicine (TCM) formula. In clinical, it has been used for the treatment of leucopenia. However, therapeutic mechanism needs further solid investigation. present study, we first tested effect QJSB on leucopenia mice induced by cyclophosphamide with administration to 8 days. Our experiments showed that significantly increased number peripheral white blood cells, platelets and nucleated bone marrow cells. Meanwhile markedly...
The aim of the present study was to identify natural compounds that bear significant anti‑tumor activity. Thus, effects 63 small molecules were isolated from traditional Chinese medicinal herbs on A549 human non‑small cell lung cancer (NSCLC) and MCF‑7 breast cells examined. It found ursolic acid (UA), a pentacyclic triterpenoid, exerted inhibitory effect these cells. Further experiments revealed UA inhibited proliferation various cells, including NSCLC H460, H1975, A549, H1299 H520, (SCLC)...
To clarify the role and molecular mechanism of mitochondrial calcium uniporter (MCU) in malignant biological behaviors oral squamous cell carcinoma (OSCC) cells through clinical cellular experiments.
Qi-Jing-Sheng-Bai granule is an effective traditional Chinese medicine formula that has been widely used for the treatment of leukopenia post radiotherapy or chemotherapy. However, its chemical constituents were still unclear, which hindered interpreting bioactive and studying integrative mechanisms. In this study, we developed a three-step strategy to characterize metabolites by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. As...
Dysregulation of mitochondrial calcium uniporter (MCU) exerts a carcinogenic effect in several cancers. Nevertheless, the roles MCU oral squamous cell carcinoma (OSCC) remain elusive. It has been reported that dihydroartemisinin (DHA) may suppress progression OSCC but its associated mechanisms have not investigated. The purpose our research was to observe biological function on and regulatory relationship with DHA. MCU, MICU1, MICU2, N-cadherin, TGF-β vimentin expression detected peritumoral...
Glioma is the most common malignant tumor of nervous system. Studies have shown microRNA-26b (miR-26b)/cyclooxygenase-2 (COX-2) axis in development and progression many cells. Our study aims to investigate effect mechanism miR-26b/COX-2 glioma. Decreased expression miR-26b with increased levels COX-2 was found glioma tissues compared matched normal tissues. A strong negative correlation observed between level 30 The then overexpressed by transfecting a mimic into U-373 invasive cell number...
For lung cancer patients with subclinical (untreated and asymptomatic) interstitial disease (ILD), there is a lack of relatively safe effective treatment. Stereotactic body radiation therapy (SBRT) can achieve high level tumor control low toxicity in early-stage non-small cell (NSCLC). This study aimed to evaluate the efficacy early stage NSCLC ILD receiving SBRT.A total 109 SBRT treatment between December 2011 August 2016 were reviewed our institutions; clinical excluded. The median dose...
Leukemia and lymphoma are common hematological malignancies in children young adults, which pose a tremendous threat to the survival of these patients worldwide, despite availability various effective treatments. The Hippo pathway is novel‑signaling that regulates organ size, cell proliferation, apoptosis tumorigenesis. chief component this transducer yes‑associated protein (YAP) over‑expressed numerous categories tumors. However, little known about effect YAP malignancies. In present study,...
Researchers need to formulate their achievements as research papers. Representative references are essential high-quality Academic citation recommendation refers providing the of citations for author papers when they write. With help recommendation, researchers can improve efficiency writing academic and reduce omission important related literature. To achieve this goal, some methods were proposed. Many them used networks learn representation chose references, tended ignore content...
Circular RNA (circRNA) is of significant interest in genetic research. The aim this study was to assess global trends circRNA research production order shed new light on future frontiers.In retrospective study, we conducted a literature search using the Web Science Core Collection (WoSCC) database March 21, 2019 retrieve publications from 2007 2018. Excel 2013, CiteSpace V, and VOSviewer were used evaluate bibliometric features that included publication output, countries/regions,...