A5100412701- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Genetic and phenotypic traits in livestock
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Animal Nutrition and Physiology
- Renal cell carcinoma treatment
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Calcium signaling and nucleotide metabolism
- Antibiotic Resistance in Bacteria
- Hippo pathway signaling and YAP/TAZ
- Neuroblastoma Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Cholesterol and Lipid Metabolism
Henan Agricultural University
2019-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Gansu Provincial Hospital
2025
Union Hospital
2016-2024
Jilin University
2015-2024
Fudan University Shanghai Cancer Center
2022
Shanghai Medical College of Fudan University
2022
Cangzhou Central Hospital
2022
Second Affiliated Hospital of Zhengzhou University
2022
Lishui Central Hospital
2021
Poultry meat quality is affected by many factors, among which intramuscular fat (IMF) predominant. IMF content affects the tenderness, juiciness, and flavor of chicken. An increasing number studies are focusing on functions lncRNAs in adipocyte differentiation. However, little known about associated with In present study, we focused an up-regulated lncRNA during adipogenetic differentiation, named fat-associated long non-coding RNA (IMFNCR). IMFNCR promotes In-depth analyses showed that acts...
Long non-coding RNAs (lncRNAs) that have no protein-coding capacity make up a large proportion of the transcriptome various species. Many lncRNAs are expressed within animal central nervous system in spatial- and temporal-specific patterns, indicating play important roles cellular processes, neural development, even cognitive behavioral processes. However, relatively little is known about their vivo functions underlying molecular mechanisms system. Here, we report neural-specific Drosophila...
Idebenone, an antioxidant used in treating oxidative damage-related diseases, has unclear neuroprotective mechanisms. Oxidative stress affects cell and mitochondrial membranes, altering Adp-ribosyl cyclase (CD38) Silent message regulator 3 (SIRT3) protein expression possibly impacting SIRT3's ability to deacetylate Tumor p53 (P53). This study explores the relationship between CD38, SIRT3, P53 H
This study aimed to elucidate the genetic basis of lipid composition in breast muscles poultry, including AA broilers, dwarf guinea fowl, quails, and pigeons, impact artificial selection on traits. By employing lipidomics transcriptomic sequencing, research analyzed chest muscle tissues these four poultry. A total 1542 molecules were identified, with 711 showing significant differences among species. These lipids primarily belonged subclasses such as TG, PC, Phosphatidylethanolamine (PE),...
<title>Abstract</title> <bold>Background: </bold>Chemotherapy is regularly recommended for surgically rectal neuroendocrine carcinoma (NEC) patients. However, the additional benefit of perioperative radiotherapy these patients unclear to date. This study aims evaluate outcome in NECs who treated with surgery and chemotherapy. <bold>Methods: </bold>This a retrospective controlled based on SEER database. Propensity score matching (PSM) was applied reduce baseline bias. Rectal underwent...
miR‑338‑3p, a recently discovered miRNA, has been shown to play important roles in tumorigenesis and metastasis various cancers. However, the exact mechanisms of miR‑338‑3p remain unknown human ovarian epithelial carcinoma (EOC). The relationship between expression pattern clinicopathological features patients with EOC were determined by real-time quantitative RT-PCR. Furthermore, role possible molecular was investigated several vitro approaches nude mouse model. We first showed that...
It is well established that vascular smooth muscle cell (VSMC) apoptosis and proliferation are critical cellular events in a variety of human diseases. However, the molecular mechanisms involved controlling VSMC still unclear. In current study, we have found programmed death 4 (PDCD4) significantly downregulated balloon-injured rat carotid arteries vivo platelet-derived growth factor-stimulated VSMCs vitro. Overexpression PDCD4 via adenovirus (Ad-PDCD4) increases an apoptotic model induced...
Abstract Emerging studies have revealed the critical role of long non‐coding RNAs (lncRNAs) in epithelial ovarian cancer (EOC) development and progression. Till now, roles potential mechanisms regarding FEZF1 antisense RNA 1 (FEZF1‐AS1) within (OC) remain unclear. The objective this study was to uncover biological function underlying mechanism LncRNA FEZF1‐AS1 OC expression levels were studied cell lines tissues human cancer. In vitro performed evaluate impact knock‐down on proliferation,...
// Li Cui 1, 2 , Siliangyu Cheng 3 Xiaojun Liu 1 Diana Messadi Yan Yang 4 Shen Hu University of California at Los Angeles, School Dentistry, CA 90095, USA Jonsson Comprehensive Cancer Center, Department Statistics, Stomatology, Zhongnan Hospital, Wuhan University, 430071, China Correspondence to: Hu, email: shenhu@ucla.edu Yang, yanyangwhu@yahoo.com Keywords: membrane proteins, metastasis, head and neck squamous cell carcinoma, syntenin-1 Received: August 25, 2016 Accepted: October 19,...
LncRNA SET-binding factor 2 (SBF2) antisense RNA1 (SBF2-AS1) has been proven to play an oncogenic role in various types of tumors, but the prognostic SBF2-AS1 especially diffuse lower-grade glioma (LGG), is still unclear. Here, we aimed investigate value LGG. The LGG expression profiles from Cancer Genome Atlas (TCGA, n = 524) and Chinese Glioma (CGGA, 431) were mined by Kaplan-Meier analysis, Cox regression Chi-square test GSEA analysis. Through found prognosis patients with high worse than...
Cervical carcinoma is one of the leading causes cancer-related death for female worldwide. Eukaryotic initiation factor 5A2 belongs to eukaryotic 5A family and proposed be a key involved in development diverse cancers. In current study, series vivo vitro investigations were performed characterize role oncogenesis metastasis cervical carcinoma. The expression status 15 patients was quantified. Then, effect knockdown on tumorigenicity ability, cell proliferation, cycle distribution, mobility...
Recently, increasing evidence has displayed that lncRNAs can exhibit crucial function in cancer progression, including lung cancer. LncRNA bladder cancer-associated transcript 1 (BLACAT1) is reported to participate various cancers. The aim of our current study was investigate the BLACAT1 non-small cell progression and functional pathway. Here, we significantly up-regulated tissues comparison adjacent normal tissues, which suggested might act as an oncogene Then, A549 PC9 cells were infected...
Patients with temporomandibular joint disorders (TMD) have high levels of inflammatory pain-related disability, which seriously affects their physical and mental health. However, an effective treatment is yet to be developed. Both circular RNAs (circRNAs) long noncoding (lncRNAs) contribute regulating pain conduction. In our current study, we report the expression profiles circRNAs, lncRNAs, mRNAs in trigeminal ganglion (TG) associated complete Freund's adjuvant (CFA)-induced TMD...
Long non-coding RNAs (lncRNAs) play important roles in transcriptional and post-transcriptional regulation. LncRNAs, which are defined as more than 200 bp length, involved key biological processes, such cell proliferation differentiation, epigenetic regulation, gene translation. Recent studies have shown that lncRNAs also major regulatory the reproduction of mammals. However, knowledge chicken ovary lacking. In this study, we performed RNA-seq analyses ovarian tissue from Hy-Line brown...
Long non-coding RNA (lncRNA) has increasingly been identified as a key regulator in pathologies such cancer. Multiple platforms were used for comprehensive analysis of ovarian cancer to identify molecular subgroups. However, lncRNA and its role mapping the subpopulation are still largely unknown. RNA-sequencing clinical characteristics acquired from The Cancer Genome Atlas database (TCGA). A total 52 lncRNAs aberrant immune specific We redefined two different subtypes, C1(188) C2(184...
The liver plays an important role in regulating lipid metabolism animals. This study investigated the function and mechanism of lncLLM hens at peak egg production. effect on intracellular content LMH cells was evaluated by qPCR, Oil Red O staining, detection triglyceride (TG) cholesterol (TC) content. interaction between MYH9 confirmed RNA purification chromatin fractionation (CHIRP) immunoprecipitation (RIP) analysis. results showed that increased TG TC promoted expression genes related to...
Background: Current epidemiological methods have limitations in identifying transmission of bacteria causing healthcare-associated infections (HAIs). Recent whole genome sequencing (WGS) studies found that genetically related strains can cause HAIs without meeting standard epidemiologic definitions, but these results could not provide data a timely fashion needed for intervention. Given recent advances Oxford Nanopore Technologies (ONT) sequencing, we sought to establish validated ONT...
As a new learning framework, Multi-Instance is labeled recently and has successfully found application in vision classification.A novel Multi-instance bag generating method presented this paper on basis of Gaussian Mixed Model.The generated GMM model composes not only color but also the locally stable unchangeable components.It frequently named as MI by researchers.Besides, another called Agglomerative Information Bottleneck clustering applied to replace MIL problem with help single-instance...