A5066782527- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Tuberculosis Research and Epidemiology
- Anesthesia and Neurotoxicity Research
- Magnesium in Health and Disease
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- Cancer therapeutics and mechanisms
- Regulation of Appetite and Obesity
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Mycobacterium research and diagnosis
- Cancer, Stress, Anesthesia, and Immune Response
- Health Literacy and Information Accessibility
- Nausea and vomiting management
- Pain Management and Placebo Effect
- Intracranial Aneurysms: Treatment and Complications
- Biochemical and Molecular Research
- Music Therapy and Health
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- Circadian rhythm and melatonin
- Social Media in Health Education
- Natural Compounds in Disease Treatment
Air Force Medical University
2013-2024
Xijing Hospital
2013-2024
University of Illinois Urbana-Champaign
2020-2023
Union Hospital
2017
Jilin University
2017
Xiangya Hospital Central South University
2017
Central South University
2017
Xi'an Honghui Hospital
2016
Xi'an Jiaotong University
2016
Weifang Medical University
2014
Summary Electroacupuncture has been demonstrated to be effective at alleviating pain and postoperative side‐effects. Our aim was investigate whether transcutaneous electric acupoint stimulation, a low‐skill alternative needle‐based electroacupuncture, could improve the quality of recovery after ambulatory surgery. Seventy‐two women scheduled for cosmetic breast surgery were randomly allocated stimulation or sham groups. Patients in group received 30 min electrical three acupoints located on...
SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium and thought to function at least in part by blocking cell wall biosynthesis inhibiting the MmpL3 transporter. It also activity bacteria protozoan parasites lack MmpL3, where it can act as an uncoupler, targeting lipid membranes Ca2+ homeostasis. Here, we synthesized 18 analogs of tested them M. smegmatis, tuberculosis, abscessus, Bacillus subtilis, Escherichia coli, well Trypanosoma brucei, T. cruzi,...
Summary Background Remote ischemic postconditioning ( RP ost C ) is a noninvasive intervention that has demonstrated cardioprotection and neuroprotection in animal studies. Objective Our goal was to investigate the cardio‐cerebral protective effects of on children undergoing open‐heart surgery for repair congenital heart defects CHD ). Methods Children were randomly assigned or control group. induced by three 5‐min cycles lower limb ischemia reperfusion using blood pressure cuff (200 mmHg)...
Ubiquitin E3 ligase-mediated protein degradation regulates osteoblast function. Itch, an ligase, affects numerous cell functions by regulating ubiquitination and proteasomal of related proteins. However, the Itch-related cellular molecular mechanisms which differentiation function are elevated during bone fracture repair as yet unknown.We examined expression levels ligases NF-κB members in callus samples quantitative polymerase chain reaction (qPCR) total amount ubiquitinated proteins...
Metadherin (MTDH) is an oncoprotein and expressed at high levels in a wide variety of human carcinomas, which represents important genetic determinant regulates multiple events tumorigenesis. MTDH promotes breast cancer cell proliferation tumorigenesis through the activation numerous signaling pathways. Currently, mecha- nism regulating expression poorly understood. Here we identified that FBXW7, component E3 ubiquitin ligase, targets for ubiquitin-mediated degradation. Forced overexpression...
N-myc downstream-regulated gene 2 (NDRG2) has been documented to be a pro-differentiative and anti-proliferative in cancer research. Our previous study found significant NDRG2 up-regulation reactive astrocytes of penumbra after transient focal cerebral ischemia, which was parallel the enhancement TUNEL-positive signals. However, it is still uncertain whether participates cellular apoptosis induced by ischemia-reperfusion injury brain. In this study, we investigated role oxygen-glucose...
Inflammation is a key element in the pathophysiology of cerebral ischemia. This study investigated role N-Myc downstream-regulated gene-2 nuclear transcription factor κB-mediated inflammation ischemia models.Mice (n = 6 to 12) with or without κB inhibitor pyrrolidinedithiocarbamate pretreatment were subjected global for 20 min. Pure astrocyte cultures astrocyte-neuron cocultures 6) exposed oxygen-glucose deprivation 4 h 2 h. Astrocytic and expression, proinflammatory cytokine secretion,...
We first reported that electroacupuncture (EA) pretreatment at the Baihui acupoint (GV20) induces ischemic tolerance. Our recent study demonstrated N-Myc downstream-regulated gene 2 (NDRG2) expression was up-regulated following transient focal cerebral ischemia. Therefore, we investigated whether NDRG2 involved in tolerance induced by EA rats.Twenty-four hours after end of last pretreatment, ischemia middle artery occlusion (MCAO) for 120 minutes male Sprague-Dawley rats. The neurobehavioral...
Extracellular adenosine is a key signaling molecule which mediates immune suppression, angiogenesis, and regulates cancer cells growth. The effect of on cervical migration invasion has not been well studied. In the current study, we used Hela SiHa cell lines to evaluate effects migration, invasion, apoptosis. results showed that treatment inhibited activities cells. Moreover, by determining expression molecules were involved in epithelial mesenchymal transition (EMT) progress, found marker...
Cis-prenyltransferases such as undecaprenyl diphosphate synthase (UPPS) and decaprenyl (DPPS) are essential enzymes in bacteria involved cell wall biosynthesis. UPPS DPPS absent the human genome, so they of interest targets for antibiotic development. Here, we screened a library 750 compounds from National Cancer Institute Diversity Set V inhibition Mycobacterium tuberculosis found 17 hits, then IC50s were determined using dose-response curves. Compounds tested growth against panel bacteria,...
Excessive and prolonged intake of highly palatable, high fat (HF) foods contributes to the pathogenesis obesity, metabolic syndrome, cognitive impairment. Exercise can restore energy homeostasis suppress HF diet preference in rats. However, it is unclear if exercise confers similar protection against detrimental outcomes associated with a chronic feeding both sexes. We used our wheel running (WR) two-diet choice (chow vs. HF) paradigm investigate efficacy reversing diet-associated...
5‑fluorouracil (5‑FU) is commonly used in the treatment of gastric cancer; however, resistance to this drug occurs under hypoxic conditions. Celecoxib may be reverse resistance. The aim present study was elucidate inhibitory effects and mechanisms 5‑FU celecoxib on cancer cell line SGC7901 cells were divided into four groups: Hypoxic control group, group 5‑FU/celecoxib combination group. Following treatment, inhibition rates determined using an MTT assay. Protein messenger RNA (mRNA)...
The simultaneous introduction of wheel running (WR) and diet choice (high-carbohydrate chow vs. high-fat diet) results in sex-specific patterns rats. WR induces a (HF) avoidance, such avoidance persists the majority males, but not females, throughout 2-wk period. Exercise is physiological stressor that activates hypothalamic-pituitary-adrenal (HPA) axis stimulates glucocorticoid (GC) release, which can alter dietary preferences. Here, we examined role HPA GC signaling mediating...
Objective: To investigate whether transcutaneous electrical acupoint stimulation (TEAS) at PC6 could reduce hypotension after spinal anesthesia (SA) in parturients and to compare the effect of TEAS different frequencies. Methods: From February 20, 2023, August 29, 90 scheduled for c-section under SA were randomly assigned receive no treatment (Control), high frequency (TEAS-HF), or low (TEAS-LF). Treatments started immediately lasted 30 min. The primary endpoint was incidence by min SA....
Objective To investigate the effects of electroacupuncture (EA) pretreatment on expression phosphorylated signal transducer and activator transcription 3 (pSTAT3) in cortical neurons a rat model focal cerebral ischemia/reperfusion (I/R) injury.Methods Forty-five adult male Sprague-Dawley rats,weighing 280-320 g,were randomly divided into groups (n =15 each):sham operation group,I/R group EA group.Focal ischemia was induced by middle artery occlusion for 120 min,followed 24 h reperfusion.EA...
SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium and thought to function at least in part by blocking cell wall biosynthesis inhibiting the MmpL3 transporter. It also activity bacteria protozoan parasites lack MmpL3, where it can act as an uncoupler, targeting lipid membranes Ca2+ homeostasis. Here, we synthesized 19 analogs of tested them bacteria: M. smegmatis, tuberculosis, abscessus, Bacillus subtilis Escherichia coli, well parasites, Trypanosoma brucei,...