A5038238285- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- Circular RNAs in diseases
- Synthesis and Biological Evaluation
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Inflammatory Bowel Disease
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Endometriosis Research and Treatment
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Adenosine and Purinergic Signaling
- Uterine Myomas and Treatments
- Vitamin D Research Studies
- Microtubule and mitosis dynamics
Nanjing Medical University
2016-2025
Changzhou No.2 People's Hospital
2017-2025
Nanjing Traditional Chinese Medicine Hospital
2025
First Affiliated Hospital of Xi'an Jiaotong University
2024
University of Minnesota
2024
Nanjing Drum Tower Hospital
2022-2024
Jiangsu Province Hospital
2009-2024
Nanjing University of Chinese Medicine
2024
Nanjing University
2023-2024
Yunnan University
2024
α-Synuclein (α-Syn), a pathological hallmark of Parkinson's disease (PD), has been recognized to induce the production interleukin-1β in process that depends, at least vitro, on nod-like receptor protein 3 (NLRP3) inflammasome monocytes. However, role NLRP3 activation onset PD not yet fully established. In this study, we showed inflammasomes were activated serum patients and midbrain model mice. We further clarified α-syn through microglial endocytosis subsequent lysosomal cathepsin B...
Nephrotoxicity is the major dose-limiting factor for clinical use of colistin against multidrug-resistant (MDR) Gram-negative bacteria. This study aimed to investigate protective effect lycopene on colistin-induced nephrotoxicity in a mouse model. Fifty mice were randomly divided into 5 groups: control group (saline solution), (20 mg/kg body weight/day administered orally), (15 mg/kg/day intravenously), mg/kg/day) plus (5 group, and group; all treated 7 days. At 12 h after last dose, blood...
Caffeine is one of the most widely consumed substances found in beverages, and has demonstrated anticancer effects several types cancer. The present study aimed to examine caffeine on gastric cancer (GC) cells (MGC‑803 SGC‑7901) vitro, determine whether apoptosis‑related caspase‑9/-3 pathway associated with these effects. sustained antiproliferative were also investigated. GC cell viability proliferation evaluated using counting colony forming assays, following treatment various...
Fecal microbiota transplantation may contribute to disease remission in ulcerative colitis; however, the factors that determine effects of treatment remain unknown. The aim present study was prospectively investigate clinical efficacy fecal patients with colitis and identify bacterial signatures associated remission. A total 20 were included this prospective uncontrolled study. All underwent gastroscopy five times, once every 3 weeks. Clinical indices used assess transplantation, as well...
We evaluated the safety and efficacy of fecal microbiota transplantation (FMT) for chronic functional constipation (CFC) ineffectively treated by conventional medication.Thirty-four patients with CFC underwent FMT treatment (three rounds, via gastroscopy). Clinical scales, including Wexner score as main index efficiency, were completed at baseline; after each treatment, 2 3 months follow up. Secondary evaluation indices included self-assessment symptoms, patient assessment quality-of-life...
During the development of hepatocellular carcinoma (HCC), mutual adaptation and interaction HCC cells microenvironment play an important role. Benzo(a)pyrene (B[a]P) is a common environmental pollutant, which can induce initiation various malignant tumors, including HCC. However, effects B[a]P exposure on progression potential mechanisms remains largely uninvestigated. Here we found that, after long-term to low dose B[a]P, it activated glucose-regulated protein 75 (GRP75), then induced...
The roles of circRNA and N6-methyladenosine (m6 A) methylation in Crohn's disease (CD) have drawn much attention. Therefore, this investigation aimed to discover how the m6 A modification circRNAs contributes CD progression.The study performed sequencing on colon samples from four patients normal controls (NCs) screen for dysregulated circRNAs. Quantitative real-time polymerase chain reaction (qRT-PCR) was validate candidate expression determine its correlation CD-associated inflammatory...
α-Synuclein (α-Syn)-induced neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Dopamine D2 receptor (Drd2) has been regarded as potential anti-inflammatory target therapy neurodegenerative diseases. However, effect astrocytic Drd2 α-Syn-induced remains unclear.The on was examined mouse primary astrocyte vitro and A53T transgenic mice vivo. The inflammatory responses were detected using immunofluorescence, ELISA, qRT-PCR. details molecular mechanism...
Collagen type X alpha 1 (COL10A1) is a member of the collagen family and main matrix component. However, COL10A1 expression prognosis relationship remains unclear in gastric cancer (GC). Through analysis database Oncomine, Cancer Genome Atlas (TCGA) as well Gene Expression Omnibus (GEO), contrast to tissue normal gastric, cancer, had been upregulated. The high was obviously related T stage (P = 0.025) lymph node metastasis 0.025). It has illustrated by logistic regression that COL10A1's...
The interaction between adherent-invasive Escherichia coli (AIEC) and intestinal macrophages is implicated in the pathogenesis of Crohn's disease (CD). However, its role fibrogenesis underlying molecular mechanisms are poorly understood. In addition, miRNAs such as let-7b may participate AIEC-macrophage interactions. this study, we identified that colonization AIEC ileum was associated with enhanced fibrosis reduced expression by enrolling a prospective cohort CD patients undergoing...
AKT plays an important role in malignant behavior of tumors. The purpose the present study was to determine expression phosphorylated (P‐AKT) and nuclear factor‐κB (NF‐κB) p65 their association with clinicopathological parameters prognosis epithelial ovarian tumor. On immunohistochemistry 115 samples tissue that included 68 specimens cancer, 12 borderline tumor, 24 benign tumor 11 normal ovary, were evaluated. Sixty‐three patients cancer followed up from 7 months. positive rate P‐AKT NF‐κB...
Abstract Cardiometabolic health is closely linked to diet. Both specific food choices and dietary indices are commonly used guide cardiometabolic protection strategies. However, the balance between foods may also significantly impact health. Here, we explore imbalance in long-term intake quantify pairing patterns (FPs), providing insights beyond conventional single-food frequencies. Using data from our GGMP (n = 6,994) NHANES 7,350) cohorts, observed that independent of single frequency...
Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss the prevention or promotion of cancer. We investigated following Roux-en-Y gastric bypass (RYGB) 18 cancers using Mendelian randomization (MR). A genome-wide association studies (GWAS) related RYGB from GWAS catalog database were used as exposure, Medical Research Council integrative epidemiology unit open project outcomes....
The major causes of mortality among patients who survive acute lung injury/ARDS (ALI/ARDS) are due to the extensive tissue remodelling and fibrosis. Use high-dose glucocorticoids reduce these inflammatory fibroproliferative responses has been shown do more harm than good. Recently, Meduri et al. found that early use low-dose prolonged methylprednisolone in with severe ALI/ARDS significantly relieved systemic response improved pulmonary extrapulmonary organ function. This study investigated...
ABSTRACT BACKGROUND AND PURPOSE Essential tremor (ET) is suggested to be a neural degenerative disease. The authors investigated the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value in basal ganglia, thalamus, red nucleus, substantia nigra ET patients using tensor image (DTI). METHODS DTI examination was carried out with controls. FA ADC values were obtained from various brain structures, including caudate, putamen+pallidum, nigra. RESULTS of nuclei higher compared...