A5090754906- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Animal Nutrition and Physiology
- Genetics and Plant Breeding
- Animal Behavior and Welfare Studies
- Genomics and Phylogenetic Studies
- Tracheal and airway disorders
- Plant Gene Expression Analysis
- Galectins and Cancer Biology
- Biofuel production and bioconversion
- Voice and Speech Disorders
- Genetic Associations and Epidemiology
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Protein Tyrosine Phosphatases
- Single-cell and spatial transcriptomics
- Effects of Environmental Stressors on Livestock
- Biochemical and biochemical processes
- Sperm and Testicular Function
- Connective tissue disorders research
- Vascular Anomalies and Treatments
- Trauma Management and Diagnosis
- Knee injuries and reconstruction techniques
- RNA modifications and cancer
Huazhong Agricultural University
2018-2024
First Affiliated Hospital of GuangXi Medical University
2021-2024
Guangxi Medical University
2021-2024
National Clinical Research Center for Digestive Diseases
2024
Chengdu Third People's Hospital
2023-2024
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2024
Southwest Jiaotong University
2023
Sichuan University
2006-2022
West China Hospital of Sichuan University
2022
Yangzhou University
2021
Abstract Limited understanding exists regarding how aging impacts the cellular and molecular aspects of human ovary. This study combines single-cell RNA sequencing spatial transcriptomics to systematically characterize ovarian aging. Spatiotemporal signatures eight types cells during are observed. An analysis age-associated changes in gene expression reveals that DNA damage response may be a key biological pathway oocyte Three granulosa subtypes five theca stromal subtypes, as well their...
Sweet potato (Ipomoea batatas L. [Lam.]) ranks among the top six most important food crops in world. It is widely grown throughout world with high and stable yield, strong adaptability, rich nutrient content, multiple uses. However, little known about molecular biology of this non-model organism due to lack genomic resources. Hence, studies based on high-throughput sequencing technologies are needed get a comprehensive integrated resource better understanding gene expression patterns...
Improved performance of crossbred animals is partly due to heterosis. One the major genetic bases heterosis dominance, but it seldom used in pedigree-based evaluation livestock. Recently, a trivariate genomic best linear unbiased prediction (GBLUP) model including dominance was developed, which can distinguish purebreds from explicitly. The objectives this study were: (1) methodological, show that inclusion marker-based inbreeding accounts for directional and depression purebred animals,...
Heat shock factors (Hsfs) are important regulators of stress-response in plants. However, our understanding Hsf genes and their responses to temperature stresses two Pooideae cool-season grasses, Festuca arundinacea Lolium perenne, is limited. Here we conducted comparative transcriptome analyses plant leaves exposed heat or cold stress for 10 h. Approximately, 30% 25% the expressed species showed significant changes under respectively, including subsets Hsfs target genes. We uncovered 74 F....
Crossbreding is predominant and intensively used in commercial meat production systems, especially poultry swine. Genomic evaluation has been successfully applied for breeding within purebreds but also offers opportunities of selecting crossbred performance by combining information from with crossbreds. However, it generally requires that all relevant animals are genotyped, which costly presently does not seem to be feasible practice. Recently, a novel single-step BLUP method genomic both...
Introduction The diagnosis and treatment of ankylosing spondylitis (AS) is a difficult task, especially in less developed countries without access to experts. To address this issue, comprehensive artificial intelligence (AI) tool was created help diagnose predict the course AS. Methods In retrospective study, dataset 5389 pelvic radiographs (PXRs) from patients treated at single medical center between March 2014 April 2022 used create an ensemble deep learning (DL) model for diagnosing then...
A single-step genomic BLUP method (ssGBLUP) has been successfully developed and applied for purebred crossbred performance in pigs. However, it requires phasing the genotypes inferring breed origin of alleles animals, which is somewhat inconvenient. Recently, a new concept metafounders that considers relationship within across base populations was developed. With this metafounders, regular methods to build invert pedigree relationships matrix can be used with only minor modifications and,...
Abstract Dominance genetic effects are rarely included in pedigree-based evaluation. With the availability of single nucleotide polymorphism markers and development genomic evaluation, estimates dominance have become feasible using best linear unbiased prediction (GBLUP). Usually, studies involving additive ignore possible relationships between them. It has been often suggested that magnitude functional at quantitative trait loci related, but there is no existing GBLUP-like approach...
Genomic prediction, which is based on solving linear mixed-model (LMM) equations, the most popular method for predicting breeding values or phenotypic performance economic traits in livestock. With need to further improve of genomic nonlinear methods have been considered as an alternative and promising approach. The excellent ability predict phenotypes animal husbandry has demonstrated by machine learning (ML) approaches, rapidly developed. To investigate feasibility reliability implementing...
Crossbreeding is widely used in pig production because of the benefits heterosis effects and breed complementarity. Commonly, sire lines are bred for traits such as feed efficiency, growth meat content, whereas maternal also reproduction longevity traits, resulting three-way crossbred pigs meat. The most important genetic basis dominance effects, e.g. removal inbreeding depression. aims this study were to (1) present a modification previously developed model with additive, depression...
Abstract Background The feed conversion ratio (FCR) is an important productive trait that greatly affects profits in the pig industry. Elucidating genetic mechanisms underpinning FCR may promote more efficient improvement of through artificial selection. In this study, we integrated a genome-wide association study (GWAS) with transcriptome analyses different tissues Yorkshire pigs (YY) aim identifying key genes and signalling pathways associated FCR. Results A total 61 significant single...
Abstract Background Genome-wide association studies (GWAS) are an effective way to explore genotype–phenotype associations in humans, animals, and plants. Various GWAS methods have been developed based on different genetic or statistical assumptions. However, no single method is optimal for all traits and, many traits, the putative nucleotide polymorphisms (SNPs) that detected by do not entirely overlap due diversity of architecture complex traits. Therefore, multi-tool-based strategies...
Genotype imputation is commonly used as an initial step in genomic selection since the accuracy of does not decline if accurately imputed genotypes are instead actual but for a lower cost. Performance has rarely been investigated crossbred animals and, particular, pigs. The extent and pattern linkage disequilibrium differ versus purebred animals, which may impact performance imputation. In this study, first we compared different scenarios from 5 K to 8 single nucleotide polymorphisms (SNPs)...
Type 1 diabetes mellitus (T1DM) is associated with different types of infections; however, studies on the causal relationship between T1DM and infectious diseases are lacking. Therefore, our study aimed to explore causalities six high-frequency infections using a Mendelian randomization (MR) approach. Two-sample MR were conducted infections: sepsis, acute lower respiratory (ALRIs), intestinal (IIs), genitourinary tract (GUTIs) in pregnancy, skin subcutaneous tissues (SSTIs), urinary (UTIs)....
Semen traits are crucial in commercial pig production since semen from boars is widely used artificial insemination for both purebred and crossbred production. Revealing the genetic architecture of potentially promotes efficiencies improving through selection. This study aimed to identify candidate genes related Duroc boars. First, we identified that were significantly associated with three traits, including sperm motility (MO), concentration (CON), volume (VOL) a boar population genome-wide...
Abstract Background Understanding the functional impact of genetic variants is essential for advancing animal genomics and improving livestock breeding. Variants that disrupt transcription factor (TF) motifs provide a means to assess potential, but lack TF ChIP-seq data farm animals presents challenge. Results To address this, we curated nearly 900 epigenomic datasets from 10 species annotated eight regulatory regions how affect motifs. Over 127 million candidate were classified into five...
Abstract The above article, published online on 27 October 2006 in Wiley Online Library ( wileyonlinelibrary.com ), has been retracted by agreement between the journal Editor‐in‐Chief, R. Shane Tubbs, and Periodicals, Inc. retraction agreed due to overlap with an article Chinese Journal of Otorhinolaryngology Head Neck Surgery (Liu et al., 2005).
Background: Epilepsy is one of the most common neurological disorders, but its underlying mechanism has remained obscure, and role immune-related genes (IRGs) in epilepsy have not yet been investigated. Therefore, this study, we explored association between IRGs epilepsy.
Abstract Background The non-coding small RNA tRFs (tRNA-derived fragments) and phasiRNAs (plant-specific) exert important roles in plant growth, development stress resistances. However, whether the respond to hormone abscisic acid (ABA) remain enigma. Results Here, RNA-sequencing was implemented decipher landscape of tomato ( Solanum lycopersicum ) leaves their responses when foliar spraying exogenous ABA after 24 h. In total, 733 137 were detected. mainly derived from tRNA Ala transporting...