A5020348729- Invertebrate Immune Response Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Cholinesterase and Neurodegenerative Diseases
- Aquaculture disease management and microbiota
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Nanoparticles: synthesis and applications
- Reproductive System and Pregnancy
- Genetics, Aging, and Longevity in Model Organisms
- Studies on Chitinases and Chitosanases
- Endoplasmic Reticulum Stress and Disease
- Heat shock proteins research
- Physiological and biochemical adaptations
- Plant Molecular Biology Research
- Galectins and Cancer Biology
- Prion Diseases and Protein Misfolding
- Hepatocellular Carcinoma Treatment and Prognosis
- Nitrogen and Sulfur Effects on Brassica
- Marine and coastal plant biology
- Vitamin D Research Studies
- Blood properties and coagulation
- Health Sciences Research and Education
- Cancer-related molecular mechanisms research
- Ethics in Clinical Research
The University of Queensland
2017-2024
Shanghai University of Traditional Chinese Medicine
2024
Shuguang Hospital
2024
Shanghai University
2024
The First People's Hospital of Wenling
2023
Chengdu Institute of Biology
2018-2020
Chinese Academy of Sciences
2006-2020
University of Chinese Academy of Sciences
2012-2020
Shanghai Institutes for Biological Sciences
2012
Army Medical University
2012
Prenatal exposure to infection is a recognized environmental risk factor for neuropsychiatric disorders of developmental origins such as autism or schizophrenia. Experimental work in animals indicates that this link mediated by maternal immune activation (MIA) involving interactions between cytokine-associated inflammatory events, oxidative stress, and other pathophysiological processes hypoferremia zinc deficiency. Maternal administration the viral mimic polyriboinosinic-polyribocytidylic...
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic map of cortex from cytoplasmic rNLS8 mouse model ALS FTLD, developed complementary open-access webtool, TDP-map ( https://shiny.rcc.uq.edu.au/TDP-map/ ). We identified distinct protein subsets enriched for diverse biological pathways...
TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% amyotrophic lateral sclerosis (ALS) and nearly half frontotemporal dementia (FTD) cases. The pathogenic mechanisms TDP-43 dysfunction are poorly understood, however, activation cell stress pathways may contribute to pathogenesis. We, therefore, sought identify which components critical for driving disease onset neurodegeneration in ALS FTD. We studied the rNLS8 transgenic mouse model, expresses human with...
Heat shock protein 90 (HSP90) works as a multi-functional chaperone and is involved in the regulation of many essential cellular pathways. In this study, we have identified full-length complementary DNA (cDNA) HSP90 (FcHSP90) from Chinese shrimp Fenneropenaeus chinensis. FcHSP90 cDNA comprised 2,552 bp, including 2,181-bp open reading frame encoding 726 amino acids. Both homology analyses using alignment with previously phylogeny tree indicated that was cytoplasmic HSP90. Real-time reverse...
Abstract Dysfunction in dopamine (DA) systems is a prominent feature schizophrenia patients and may result from the abnormal development of mesencephalic (mes)DA systems. Maternal immune activation (MIA) developmental vitamin D (DVD)-deficiency both induce schizophrenia-relevant dopaminergic abnormalities adult offspring. In this study, we investigated whether maternal administration hormone (1,25OHD, VIT ) could prevent MIA-induced DA-related behaviors mesDA development. We administrated...
Extra-motor symptoms are increasingly recognised in amyotrophic lateral sclerosis (ALS), encompassing cognitive, social, and behavioural deficits that can substantially impact quality of life. TAR DNA binding protein 43 (TDP-43) pathology is the central disease marker almost all cases ALS approximately half frontotemporal dementia (FTD). However, mechanisms linking TDP-43 with extra-motor TDP-43-associated neurodegenerative diseases remain unresolved. In this study, we used rNLS8 mouse...
The heat shock protein 70 (Hsp70) family is widely expressed in eukaryotic cells as the major chaperone protein. In this study, full-length complementary DNA (cDNA) of a novel inducible cytosolic Hsp70 member (FcHsp70) was cloned from Fenneropenaeus chinensis. FcHsp70 cDNA consists 2,511 bp with 1,890-bp open reading frame encoding 629 amino acids. Three signatures, IDLGTTYS, IIDLGGGTFDVSIL, and IVLVGGSTRIPKVQK, were found predicted acid sequence. Phylogenetic analysis showed that...
Tumor cells acquire the capacity of resistance to chemotherapy or radiotherapy via cell-matrix and cell-cell crosstalk. Integrins are most important cell adhesion molecules, in which αV integrin mainly mediating tight contact between tumor cells.
Abstract Dopaminergic (DA) dysfunction is a significant feature in the pathophysiology of schizophrenia. Established developmental risk factors for schizophrenia such as maternal immune activation (MIA) or vitamin D (DVD) deficiency, when modelled animals, reveal differentiation early DA neurons foetal brains delayed suggesting this may be convergent aetiological pathway. Here we have assessed effects prenatal hypoxia, another well-known factor schizophrenia, on developing systems. Pregnant...
Abstract Background The non-coding small RNA tRFs (tRNA-derived fragments) and phasiRNAs (plant-specific) exert important roles in plant growth, development stress resistances. However, whether the respond to hormone abscisic acid (ABA) remain enigma. Results Here, RNA-sequencing was implemented decipher landscape of tomato ( Solanum lycopersicum ) leaves their responses when foliar spraying exogenous ABA after 24 h. In total, 733 137 were detected. mainly derived from tRNA Ala transporting...
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To address this, we sought determine timeline of proteomic alterations across disease course in proteinopathy. Using longitudinal quantitative proteomics analysis cortex samples from cytoplasmic rNLS8 mouse model ALS FTLD, identified several distinct protein subsets characterized by...