A5025652647- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Advanced Proteomics Techniques and Applications
- Retinal Development and Disorders
- Plant Stress Responses and Tolerance
- Metabolomics and Mass Spectrometry Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant responses to water stress
- Photosynthetic Processes and Mechanisms
- GABA and Rice Research
- Plant nutrient uptake and metabolism
- Endoplasmic Reticulum Stress and Disease
- Retinoids in leukemia and cellular processes
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Cholinesterase and Neurodegenerative Diseases
- Sperm and Testicular Function
- Plant-Microbe Interactions and Immunity
- Sphingolipid Metabolism and Signaling
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
- Reproductive Biology and Fertility
- Rice Cultivation and Yield Improvement
Macquarie University
2016-2025
Australian Genome Research Facility
2017-2024
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
Shahid Beheshti University
2022
Gorgan University of Agricultural Sciences and Natural Resources
2022
Agricultural Biotechnology Research Institute of Iran
2022
Agricultural Research & Education Organization
2022
European Brain Research Institute
2022
Cedars-Sinai Medical Center
2022
Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly early stages of functional impairment, how they relate to progression brain remain largely unknown. To better understand pathological features AD retina, we conducted an extensive histopathological biochemical investigation postmortem retina tissues from 86 human donors. Quantitative examination superior inferior temporal retinas...
Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate association between glaucoma and by investigating glaucoma-associated protein changes in retina vitreous humour. The multiplexed Tandem Mass Tag based proteomics (TMT-MS3) carried out on retinal tissue humour fluid collected from patients age-matched controls followed functional pathway network interaction analysis. About 5000...
There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies needed to model this condition and prevent or delay its progression. Induced pluripotent stem cells generated from patients with atrophy healthy individuals were differentiated retinal pigment epithelium. Integrating transcriptional profiles 127,659 epithelium 43 36 controls genotype data, we identify 445 expression quantitative trait loci in cis that...
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis considered the main pathological hallmarks this devastating disease. Physiologically, these two proteins produced expressed within normal human body. However, under conditions, abnormal expression, post-translational modifications, conformational changes, truncation can make prone aggregation, triggering specific disease-related cascades. Recent studies...
Abstract INTRODUCTION Vascular amyloid beta (Aβ) protein deposits were detected in retinas of mild cognitively impaired (MCI) and Alzheimer's disease (AD) patients. We tested the hypothesis that retinal vascular tight junctions (TJs) compromised linked to status. METHODS TJ components Aβ expression capillaries larger blood vessels determined post mortem from 34 MCI or AD patients 27 normal controls correlated with neuropathology. RESULTS Severe decreases zonula occludens‐1 (ZO‐1) claudin‐5...
Abstract Astrocytes play a role in healthy cognitive function and Alzheimer’s disease (AD). The transcriptional factor nuclear factor-κB (NF-κB) drives astrocyte diversity, but the mechanisms are not fully understood. By combining studies human brains animal models selectively manipulating NF-κB astrocytes, we deepened understanding of astrocytic brain health AD. In silico analysis bulk cell-specific transcriptomic data revealed association astrocytes Confocal validated higher level p50...
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic map of cortex from cytoplasmic rNLS8 mouse model ALS FTLD, developed complementary open-access webtool, TDP-map ( https://shiny.rcc.uq.edu.au/TDP-map/ ). We identified distinct protein subsets enriched for diverse biological pathways...
Abstract Extracellular vesicles (EVs) are nanosized with a lipid bilayer that secreted by cells and play critical role in cell‐to‐cell communication. Despite the promising reports regarding their diagnostic therapeutic potential, utilization of EVs clinical setting is limited due to insufficient information about cargo lack standardization isolation analysis methods. Considering protein cargos as key contributors potency, we conducted tandem mass tag (TMT) quantitative proteomics three...
Rice (Oryza sativa L. cv. IR64) was grown in split-root systems to analyze long-distance drought signaling within root systems. This turn underpins how heterogeneous soils adapt drought. The approach compare four tissues: (1) fully watered; (2) droughted and where (3) one-half watered (4) the other half droughted. specifically aimed at identifying tissues altered proteome of adjacent wet roots by hormone signals reciprocally affected dry hydraulically. Quantitative label-free shotgun...
Although it is apparent that chromosome complement mediates sexually dimorphic expression patterns of some proteins lead to functional differences, there has been insufficient evidence following the manipulation male-specific region Y (MSY) gene during neural development. In this study, we profiled 23 MSY genes and 15 their X-linked homologues cell differentiation NTERA-2 human embryonal carcinoma line (NT2) cells in three different developmental stages using qRT-PCR, Western blotting,...
Mechanisms of drought tolerance are complex, interacting, and polygenic. This paper describes patterns gene expression at precise physiological stages in 35-day-old seedlings Oryza sativa cv. Nipponbare. Drought was imposed gradually for up to 15 days, causing abscisic acid levels rise growth cease, plants were then re-watered. Proteins identified from leaf samples after moderate drought, extreme 3 6 days re-watering. Label-free quantitative shotgun proteomics resulted identification 1548...