A5016322782- Endoplasmic Reticulum Stress and Disease
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Retinoids in leukemia and cellular processes
- Alzheimer's disease research and treatments
- Antioxidant Activity and Oxidative Stress
- Caveolin-1 and cellular processes
- Ubiquitin and proteasome pathways
- Calpain Protease Function and Regulation
- Galectins and Cancer Biology
- Protein Tyrosine Phosphatases
- Viral Infectious Diseases and Gene Expression in Insects
- Cell death mechanisms and regulation
- Cellular transport and secretion
- Sphingolipid Metabolism and Signaling
- Heat shock proteins research
- S100 Proteins and Annexins
- interferon and immune responses
- Connexins and lens biology
- Neurological diseases and metabolism
- Photochromic and Fluorescence Chemistry
- Virus-based gene therapy research
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
Macquarie University
2016-2020
Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate association between glaucoma and by investigating glaucoma-associated protein changes in retina vitreous humour. The multiplexed Tandem Mass Tag based proteomics (TMT-MS3) carried out on retinal tissue humour fluid collected from patients age-matched controls followed functional pathway network interaction analysis. About 5000...
The spread of neurodegeneration through the human brain network is reported as underlying progression neurodegenerative disorders. However, exact mechanisms remain unknown. visual pathway characterized by its unique hierarchical architecture and, therefore, represents an ideal model to study trans-synaptic degeneration, in contrast complexity neural connectivity whole brain. Here we show two specifically selected patient cohorts, including (i) glaucoma patients with symmetrical bilateral...
Glaucoma is characterized by the loss of retinal ganglion cells (RGC), and accordingly preservation RGCs their axons has recently attracted significant attention to improve therapeutic outcomes in disease. Here, we report that Src homology region 2-containing protein tyrosine phosphatase 2 (Shp2) undergoes activation RGCs, animal model glaucoma as well human tissues Shp2 dephosphorylates tropomyosin receptor kinase B (TrkB) receptor, leading reduced BDNF/TrkB neuroprotective survival...
Amyloid β (Aβ) accumulation and its aggregation is characteristic molecular feature of the development Alzheimer's disease (AD). More recently, Aβ has been suggested to be associated with retinal pathology AD, glaucoma drusen deposits in age related macular degeneration (AMD). In this study, we investigated proteins biochemical networks that are affected by amyloid 661W photoreceptor cells culture. Time dose dependent effects on were determined utilising tandem mass tag (TMT) labelling-based...
Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in neuronal tissues. This study provides novel evidence regulatory effect neuroserpin on proteolytic retina glaucoma. Human retinal vitreous tissues from control glaucoma subjects as well retinas experimental rats were analysed to establish changes activity. undergoes oxidative inactivation which leads augmentation contains several methionine residues addition conserved reactive site our...
Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand activation, these control gene transcription via either homodimerization with themselves or heterodimerization partner-nuclear receptor. The protective effects of RXRs RXR agonists have been reported in several neurodegenerative diseases, including retina. This study was aimed prioritize compounds from natural synthetic origin retinoids as potential by molecular docking dynamic simulation strategies....
TrkB is a high affinity receptor for the brain derived neurotrophic factor (BDNF) and its phosphorylation stimulates activation of several intracellular signalling pathways linked to cellular growth, differentiation maintenance. Identification various activators inhibitors greater understanding their binding mechanisms critical elucidate biochemical pharmacological analyse protein crystallization studies. The data presented here related research article entitled "Brain Derived involved in...
Neurotrophic factors, particularly Brain Derived Factor (BDNF) and its high affinity receptor TrkB, play an important role in protecting the retinal ganglion cells (RGCs) glaucoma. Translation of immense neuro-protective potential BDNF/TrkB activation has been largely unsuccessful gene therapy to modulate BDNF TrkB have also shown only short-lived protective effects on RGCs. PTPN11 phosphatase plays a key regulation signaling retina. Here, we investigated modulation involving both...
Purpose Variations in Caveolin1/2 (Cav1/2) gene loci has been identified a risk factor glaucoma. Cav-1 is the prominent signature protein of caveola and implicated various signal transduction pathways. ablation previously shown to impair retinal function our study established that it involved regulation BDNF/TrkB signalling ganglion cells. This aimed investigate role specifically inner retina both healthy experimental glaucoma conditions. Methods Cav-1−/− age matched wildtype mice were used...