A5100774061- Tuberculosis Research and Epidemiology
- Computational Drug Discovery Methods
- DNA Repair Mechanisms
- Genetics and Plant Breeding
- Plant Stress Responses and Tolerance
- Plant Micronutrient Interactions and Effects
- Cancer therapeutics and mechanisms
- Fungal and yeast genetics research
- Agricultural Science and Fertilization
- Plant nutrient uptake and metabolism
- Mycobacterium research and diagnosis
- Genetic Mapping and Diversity in Plants and Animals
- Plant Pathogens and Fungal Diseases
- RNA and protein synthesis mechanisms
- Quinazolinone synthesis and applications
- Biochemical and Molecular Research
- Plant Molecular Biology Research
- Bacterial Genetics and Biotechnology
- Plant responses to water stress
- Rice Cultivation and Yield Improvement
- Agricultural Economics and Practices
- Garlic and Onion Studies
- Synthesis and biological activity
- Free Radicals and Antioxidants
- Protein Structure and Dynamics
Central Drug Research Institute
2012-2024
Sharda University
2024
City College of New York
2024
Graphic Era University
2023-2024
Biotech Park
2015-2023
Bhabha Atomic Research Centre
2023
University of Delhi
2023
Bridge University
2023
University College of Medical Sciences
2023
Academy of Scientific and Innovative Research
2021-2023
Late embryogenesis abundant (LEA) proteins, the space fillers or molecular shields, are hydrophilic protective proteins which play an important role during plant development and abiotic stress. The systematic survey characterization revealed a total of 68 LEA genes, belonging to 8 families in Sorghum bicolor. LEA-2, typical hydrophobic family is most family. All them evenly distributed on all 10 chromosomes 1, 2, 3 appear be hot spots. Majority S. bicolor (SbLEA) genes intron less have fewer...
Abstract Parkinson’s disease (PD) arises as neurodegenerative disorder and characterized by progressive deterioration of motor functions due to forfeiture dopamine-releasing neurons. During PD, neurons at stake loss their functionality that results into cognition impairment forgetfulness, commonly called dementia. Recently, nanoparticles (NPs) have been reported for easy drug delivery through blood-brain barrier (BBB) the central nervous system (CNS) against conventional systems. However,...
RWP-RKs represent a small family of transcription factors (TFs) that are unique to plants and function particularly under conditions nitrogen starvation. These have been classified in two sub-families, NLPs (NIN-like proteins) RKDs (RWP-RK domain proteins). regulate tissue-specific expression genes involved use efficiency (NUE) gametogenesis/embryogenesis. During the present study, using silico approach, 37 wheat RWP-RK were identified, which included 18 TaNLPs (2865 7340 bp with 4/5 exons),...
GPR142 (G protein receptor 142) is a novel orphan GPCR coupled receptor) belonging to "Class A" of family and expressed in β cells pancreas. In this study, we reported the structure based virtual screening identify hit compounds which can be developed as leads for potential agonists. The results were validated through induced fit docking, pharmacophore modeling, system biology approaches. Since, there no solved crystal GPR142, attempted predict 3D followed by validation then identification...
The Swi1 and Swi3 proteins are required for mat1 imprinting mating-type switching in Schizosaccharomyces pombe, where they mediate a pause of leading-strand replication response to lagging-strand signal. In addition, has been demonstrated be involved the checkpoint stalled forks, as was described Saccharomyces cerevisiae homologue Tof1. This study addresses roles during process perturbed by presence template bases alkylated methyl methanesulfonate (MMS). Both swi1 swi3 mutations have...
7,8-dihydroxyflavone (7,8-DHF) is a TrkB receptor agonist, and treatment with this flavonoid derivative brings about an enhanced phosphorylation promotes downstream cellular signalling. Flavonoids are also known to exert inhibitory effect on the vascular endothelial growth factor (VEGFR) family of tyrosine kinase receptors. VEGFR2 one important receptors involved in regulation vasculogenesis angiogenesis has been implicated exhibit various neuroprotective roles. Its upregulation uncontrolled...
The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in response to damage, is poorly understood. Is damage recognized directly, or indirectly through its effects on replication forks? the slowing of S phase part because competition between and recombination/repair processes? results our genetic analyses checkpoint fission yeast, Schizosaccharomyces pombe , suggest that depends weakly helicases Rqh1 Srs2 but not other pathways. strongly six checkpoint-Rad proteins, Cds1,...
Small heat shock protein16.3 (sHSP16.3) is a crucial protein for survival of Mycobacterium tuberculosis (MTB) in its host. Besides, this acts as molecular chaperone during stress and indispensable MTB's growth, virulence cell-wall thickening. sHSP16.3 also promising candidate vaccine, serodiagnosis drug design well. In the present study, we have targeted with two phytochemicals, namely ursolic acid carvacrol using silico approach. Molecular docking analysis showed that both phytochemicals...
To elucidate the checkpoint mechanism responsible for slowing passage through S phase when fission yeast cells are treated with DNA-damaging agent methyl methanesulfonate (MMS), we carried out two-dimensional gel analyses of replication intermediates in synchronized by cdc10 block (in G(1)) followed release into synchronous phase. The results indicated that under these conditions early-firing centromeric origins were partially delayed but late-firing telomeric not delayed. Replication...
Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand activation, these control gene transcription via either homodimerization with themselves or heterodimerization partner-nuclear receptor. The protective effects of RXRs RXR agonists have been reported in several neurodegenerative diseases, including retina. This study was aimed prioritize compounds from natural synthetic origin retinoids as potential by molecular docking dynamic simulation strategies....
In plants, the enzyme CCD8 (carotenoid cleavage dioxygenase 8) is involved in synthesis of an important hormone, strigolactone, and therefore, plays role controlling growth development. Using cDNA protein sequence derived from gene ZmCCD8 maize, we identified putative orthologs encoding six other monocots eight dicots; similarity ranged 52-75.9% at level 60.9-93.7% level. The average length was ~3.3 kb (range: 2.08 to 3.98 kb), although number introns within genes differed (4 or 5 dicots 3 4...