A5069655623- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Pneumocystis jirovecii pneumonia detection and treatment
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Plant biochemistry and biosynthesis
- vaccines and immunoinformatics approaches
- Microbial Natural Products and Biosynthesis
- SARS-CoV-2 and COVID-19 Research
- Click Chemistry and Applications
- Synthesis and biological activity
- Pharmacological Effects of Natural Compounds
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Synthesis and Biological Evaluation
- Phytochemistry and biological activity of medicinal plants
- Multicomponent Synthesis of Heterocycles
- Herbal Medicine Research Studies
- Phytochemical compounds biological activities
- Biochemical and Structural Characterization
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
Central University of Rajasthan
2023-2024
Jawaharlal Nehru University
2020-2021
Oil and Natural Gas Corporation (India)
2020
Koneru Lakshmaiah Education Foundation
2020
Academy of Scientific and Innovative Research
2014-2016
Indian Institute of Integrative Medicine
2012-2016
Czech Academy of Sciences, Institute of Microbiology
2015
Birla Institute of Technology and Science, Pilani
2014
Council of Scientific and Industrial Research
2013
The present study was designed to investigate the antimicrobial activity and cytotoxicity of methanol extract (PLA) as well fractions (PLA1-4) compounds [cardamomin (1), (±)-polygohomoisoflavanone (2), (S)-(-)-pinostrobin (3), 2',4'-dihydroxy-3',6'-dimethoxychalcone (4), (2S)-(-)-5-hydroxy-6,7-dimethoxyflavanone (5), (2S)-(-)-5,7-dimethoxyflavanone (6)] obtained from leaves Polygonum limbatum. microbroth dilution used determine minimal inhibitory concentration (MIC) samples against 11...
Abstract Tuberculosis is one the oldest known affliction of mankind caused by pathogen Mycobacterium tuberculosis . Till date, there no absolute single treatment available to deal with pathogen, which has acquired a great potential develop drug resistance rapidly. BCG only anti-tuberculosis vaccine till date displays limited global efficacy due genetic variation and concurrent infections. Extracellular vesicles or exosomes vesicle (EVs) lie at frontier cellular talk between host, therefore...
Couroupita guianensis Aubl. (Lecythidaceae) is commonly called Ayahuma and the Cannonball tree. It distributed in tropical regions of northern South America Southern Caribbean. has several medicinal properties. used to treat hypertension, tumours, pain, inflammatory processes, cold, stomach ache, skin diseases, malaria, wounds toothache. The fruits were extracted with chloroform. Antimicrobial, antimycobacterial antibiofilm forming activities chloroform extract investigated. Quantitative...
Whole-cell screening of 20,000 drug-like small molecules led to the identification nitrofuranyl methylpiperazines as potent anti-TB agents. In present study, validation followed by medicinal chemistry has been used explore structure–activity relationship. Ten compounds demonstrated MIC in range 0.17–0.0072 μM against H37Rv Mycobacterium tuberculosis (MTB) and were further investigated nonreplicating resistant (RifR MDR) strains MTB. These also tested for cytotoxicity. Among 10 compounds,...
Promising nitroimidazoloxazole scaffold gives another novel triazolyl-containing 6-nitro-2,3-dihydroimidazooxazole as anti-TB lead.
Mycobacterium tuberculosis shikimate kinase (Mtb-SK) is a key enzyme involved in the biosynthesis of aromatic amino acids through pathway. Since it proven to be essential for survival microbe and absent from mammals, promising target anti-TB drug discovery. In this study, combined approach silico similarity search pharmacophore building using already reported inhibitors was used screen procured library 20,000 compounds commercially available ChemBridge database. From screening, 15 hits were...
The global health emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to alarming numbers of fatalities across world. So far researchers worldwide have not been able discover a breakthrough in form potent drug or an effective vaccine. Therefore, it is imperative drugs curb ongoing menace. In silico approaches using FDA approved can expedite discovery process providing leads that be pursued. this report, two targets, namely spike protein and main...
Here, a medicinal chemistry study of an N-alkylphenyl-3,5-dinitrobenzamide (DNB) scaffold as potent anti-TB agent is presented. A series chemical modifications were performed and forty-three new molecules synthesized to the structure–activity relationship (SAR) by evaluating against sensitive strain (H37Rv) Mycobacterium tuberculosis (MTB). Potent DNB analogs 4b, 7a, 7c, 7d, 7j, 7r 9a further tested resistant strains MTB. Their intracellular well bactericidal potential was also evaluated....
Summary The development of concentrated and highly stable oil-in-water (O/W) emulsion is considered to be a cost-effective alternative for the transportation produced heavy crude oils. However, demulsification transported O/W necessary once it reaches destination. This article experimentally investigates performance four low-cost chemicals varying water solubility as potential demulsifiers, independently in combinations, demulsifying two Indian emulsions prepared pipeline transportation....
SARS-CoV-2, the causative agent behind ongoing pandemic exhibits an enhanced potential for infection when compared to its related family members- SARS-CoV and MERS-CoV; which have caused similar disease outbreaks in past. The severity of global health burden, increasing mortality rate emergent economic crisis urgently demands development next generation vaccines. Amongst such vaccines are multi-epitope subunit vaccines, hold promise combating deadly pathogens. In this study we exploited...
Abstract Here we have developed ligand free palladium catalyzed Suzuki coupling of 3‐bromo‐1‐methyl‐4‐indolylmaleimide under room temperature condition. Twenty unsymmetrical indolylmaleimide derivatives ( 4 a ‐ t ) were synthesised using various aryl‐ and heteroarylboronic acids in good to excellent yields. Synthesised compounds further screened for its antimicrobial activity. Compounds q displayed significant minimum inhibitory concentration (MIC) value 2.3µM toward S. aureus . was also...